Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics (Q21134703)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22496808 AND SRC:MED&resulttype=core&format=json

28 January 2020

title

Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics (English)

1 reference

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28 January 2020

2

Alexandre R Gingras

Alexandre R

Gingras

1 reference

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28 January 2020

7

Benjamin T Goult

Benjamin T

Goult

1 reference

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28 January 2020

3

Alexia

Bachir

Alexia Bachir

1 reference

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28 January 2020

Neil Bate

1

Neil

Bate

1 reference

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28 January 2020

Rick Horwitz

4

Rick

Horwitz

1 reference

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28 January 2020

Feng Ye

5

Feng

Ye

1 reference

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28 January 2020

Bipin Patel

6

Bipin

Patel

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22496808 AND SRC:MED&resulttype=core&format=json

28 January 2020

David R Critchley

8

David R

Critchley

1 reference

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28 January 2020

language of work or name

English

0 references

publication date

4 April 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22496808 AND SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22496808 AND SRC:MED&resulttype=core&format=json

28 January 2020

volume

7

1 reference

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28 January 2020

issue

4

1 reference

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28 January 2020

page(s)

e34461

1 reference

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Creative Commons Attribution 4.0 International

28 January 2020

copyright license

start time

4 April 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3319578/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle

1 reference

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Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes

19 March 2017

1 reference

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The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

19 March 2017

1 reference

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Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

19 March 2017

1 reference

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Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

19 March 2017

1 reference

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The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.

19 March 2017

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Structural Determinants of Integrin Binding to the Talin Rod

19 March 2017

1 reference

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The structure of the C-terminal actin-binding domain of talin

19 March 2017

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The CCPN data model for NMR spectroscopy: development of a software pipeline

19 March 2017

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Cell migration: integrating signals from front to back

19 March 2017

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Comparative protein modelling by satisfaction of spatial restraints

19 March 2017

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Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin

19 March 2017

1 reference

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Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin

19 March 2017

1 reference

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Site-directed mutagenesis of alpha II spectrin at codon 1175 modulates its mu-calpain susceptibility

19 March 2017

1 reference

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Sequence and domain structure of talin

19 March 2017

1 reference

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Cell adhesion: integrating cytoskeletal dynamics and cellular tension

19 March 2017

1 reference

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Comparative protein structure modeling using Modeller

7 April 2017

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Functional atlas of the integrin adhesome

7 April 2017

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FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

The C terminus of talin links integrins to cell cycle progression.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration

12 September 2017

1 reference

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The tail of integrin activation

12 September 2017

1 reference

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m-Calpain activation is regulated by its membrane localization and by its binding to phosphatidylinositol 4,5-bisphosphate.

12 September 2017

1 reference

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Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.

12 September 2017

1 reference

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The final steps of integrin activation: the end game

12 September 2017

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Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity

12 September 2017

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Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK).

12 September 2017

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Biochemical and structural properties of the integrin-associated cytoskeletal protein talin

12 September 2017

1 reference

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Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration.

12 September 2017

1 reference

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Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms

12 September 2017

1 reference

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Talin depletion reveals independence of initial cell spreading from integrin activation and traction

12 September 2017

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Integrins in cell migration--the actin connection

12 September 2017

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Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails

12 September 2017

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Integrin signalling at a glance

12 September 2017

1 reference

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Vinculin controls focal adhesion formation by direct interactions with talin and actin.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

A molecular switch that controls cell spreading and retraction

12 September 2017

1 reference

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The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

Talin2 is induced during striated muscle differentiation and is targeted to stable adhesion complexes in mature muscle

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

The structure and regulation of vinculin.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

Calpain involvement in the remodeling of cytoskeletal anchorage complexes

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

ILK, PINCH and parvin: the tIPP of integrin signalling

12 September 2017

1 reference

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Cutting to the chase: calpain proteases in cell motility

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

Vinculin knockout results in heart and brain defects during embryonic development

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

Calpain-mediated proteolysis of talin regulates adhesion dynamics

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

Monoclonal antibodies recognizing the N- and C-terminal regions of talin disrupt actin stress fibers when microinjected into human fibroblasts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

The behavior of calpain-generated N- and C-terminal fragments of talin in integrin-mediated signaling pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

Disruption of the talin gene compromises focal adhesion assembly in undifferentiated but not differentiated embryonic stem cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

30 May 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0034461

Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0034461

Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0034461

Characterization of an Actin-binding Site within the Talin FERM Domain

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0034461

Calpain 1-gamma filamin interaction in muscle cells: a possible in situ regulation by PKC-alpha

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319578

Identification of functional domains in the cytoskeletal protein talin

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22496808

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Role of vinculin in regulating focal adhesion turnover

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22496808

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0034461

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22496808 AND SRC:MED&resulttype=core&format=json

28 January 2020

ADS bibcode

2012PLoSO...734461B

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22496808 AND SRC:MED&resulttype=core&format=json

28 January 2020

PubMed publication ID

22496808

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22496808 AND SRC:MED&resulttype=core&format=json