Sortilin related receptor 1 (Q21134412)

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mammalian protein found in Homo sapiens

low-density lipoprotein receptor relative with 11 ligand-binding repeats
SORL1
LDLR relative with 11 ligand-binding repeats
mosaic protein LR11
sortilin-related receptor
sorting protein-related receptor containing LDLR class A repeats
SorLA
LR11
sortilin-related receptor, L(DLR class) A repeats containing
SorLA-1

Language	Label	Description	Also known as
English	Sortilin related receptor 1	mammalian protein found in Homo sapiens	low-density lipoprotein receptor relative with 11 ligand-binding repeats SORL1 LDLR relative with 11 ligand-binding repeats mosaic protein LR11 sortilin-related receptor sorting protein-related receptor containing LDLR class A repeats SorLA LR11 sortilin-related receptor, L(DLR class) A repeats containing SorLA-1

Statements

1 reference

13 November 2019

UniProt protein ID

Fibronectin type III superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92673

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92673

LDL receptor-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92673

Six-bladed beta-propeller, TolB-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92673

WD40/YVTN repeat-like-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92673

Putative uncharacterized transport proteins

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

VPS10, protein family

1 reference

based on heuristic

inferred from protein domain or family

Sortilin, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fibronectin type III, protein family

1 reference

based on heuristic

inferred from protein domain or family

Sortilin, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Low-density lipoprotein (LDL) receptor class A, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Low-density lipoprotein (LDL) receptor class A repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

LDLR class B repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

amyloid-beta binding

determination method or standard

low-density lipoprotein particle binding

determination method or standard

1 reference

3 January 2017

Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

protein binding

determination method or standard

5 references

3 January 2017

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

transmembrane signaling receptor activity

determination method or standard

1 reference

3 January 2017

A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

recycling endosome

determination method or standard

1 reference

3 January 2017

GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

determination method or standard

1 reference

3 January 2017

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

3 January 2017

A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

extracellular region

determination method or standard

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

trans-Golgi network

determination method or standard

1 reference

3 January 2017

SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

determination method or standard

endoplasmic reticulum

determination method or standard

1 reference

3 January 2017

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

low-density lipoprotein particle

determination method or standard

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

nuclear envelope lumen

determination method or standard

3 references

3 January 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

determination method or standard

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

extracellular space

determination method or standard

1 reference

3 January 2017

LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

endosome membrane

determination method or standard

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

biological process

protein targeting

determination method or standard

steroid metabolic process

determination method or standard

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

lipid transport

determination method or standard

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

protein targeting to lysosome

determination method or standard

1 reference

3 January 2017

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

determination method or standard

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

positive regulation of protein catabolic process

determination method or standard

1 reference

3 January 2017

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

lipid metabolism

determination method or standard

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

negative regulation of amyloid-beta formation

determination method or standard

7 references

3 January 2017

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

negative regulation of protein oligomerization

determination method or standard

1 reference

3 January 2017

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

protein maturation

determination method or standard

1 reference

3 January 2017

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

determination method or standard

4 references

3 January 2017

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

cholesterol metabolic process

determination method or standard

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

negative regulation of protein binding

determination method or standard

1 reference

3 January 2017

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

positive regulation of ER to Golgi vesicle-mediated transport

determination method or standard

1 reference

3 January 2017

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

receptor-mediated endocytosis

determination method or standard

1 reference

3 January 2017

A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

positive regulation of early endosome to recycling endosome transport

determination method or standard

1 reference

3 January 2017

GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

post-Golgi vesicle-mediated transport

determination method or standard

1 reference

3 January 2017

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

positive regulation of endocytic recycling

determination method or standard

1 reference

3 January 2017

GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

regulation of smooth muscle cell migration

determination method or standard

1 reference

3 January 2017

LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

positive regulation of protein localization to early endosome

determination method or standard

1 reference

3 January 2017

GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

determination method or standard

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process

determination method or standard

3 references

3 January 2017

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

3 January 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

positive regulation of protein exit from endoplasmic reticulum

determination method or standard

1 reference

3 January 2017

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

signal transduction

determination method or standard

1 reference

3 January 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q92673

determination method or standard

Low-density lipoprotein (LDL) receptor class A, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92673

fibronectin type III

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92673

Sortilin, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92673

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92673

low-density lipoprotein (LDL) receptor class A repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92673

Sortilin, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92673

LDLR class B repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92673

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000260197

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000260197

ENSP00000432131

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000432131

ENSP00000434634

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434634

ENSP00000435405

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435405

ENSP00000436447

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000436447

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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