MAPK activated protein kinase 5 (Q21133150)

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mammalian protein found in Homo sapiens

p38-regulated/activated protein kinase
MAPKAPK5
mitogen-activated protein kinase-activated protein kinase 5
MAP kinase-activated protein kinase 5
PRAK
MAPKAP kinase 5
MAPKAPK-5
MAPK-activated protein kinase 5

Language	Label	Description	Also known as
English	MAPK activated protein kinase 5	mammalian protein found in Homo sapiens	p38-regulated/activated protein kinase MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 MAP kinase-activated protein kinase 5 PRAK MAPKAP kinase 5 MAPKAPK-5 MAPK-activated protein kinase 5

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IW41

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

protein kinase activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

calcium-dependent protein serine/threonine kinase activity

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

determination method or standard

1 reference

8 April 2019

PRAK is essential for ras-induced senescence and tumor suppression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

calmodulin binding

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

kinase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

protein serine/threonine kinase activity

determination method or standard

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

8 April 2019

PRAK, a novel protein kinase regulated by the p38 MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

8 April 2019

PRAK is essential for ras-induced senescence and tumor suppression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

8 April 2019

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

8 April 2019

PRAK is essential for ras-induced senescence and tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

protein binding

determination method or standard

8 references

8 April 2019

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

8 April 2019

The protein interaction landscape of the human CMGC kinase group

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

8 April 2019

A directed protein interaction network for investigating intracellular signal transduction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

8 April 2019

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

8 April 2019

A human MAP kinase interactome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

8 April 2019

PRAK is essential for ras-induced senescence and tumor suppression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

8 April 2019

Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAPK-induced heat shock protein 27 phosphorylation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

calmodulin-dependent protein kinase activity

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

MAP kinase kinase activity

determination method or standard

1 reference

8 April 2019

PRAK, a novel protein kinase regulated by the p38 MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

mitogen-activated protein kinase binding

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

biological process

positive regulation of telomere capping

determination method or standard

1 reference

8 April 2019

High-throughput RNAi screening reveals novel regulators of telomerase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

phosphorylation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

stress-induced premature senescence

determination method or standard

1 reference

8 April 2019

PRAK is essential for ras-induced senescence and tumor suppression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

positive regulation of telomere maintenance via telomerase

determination method or standard

1 reference

8 April 2019

High-throughput RNAi screening reveals novel regulators of telomerase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

protein phosphorylation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

peptidyl-serine phosphorylation

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

positive regulation of telomerase activity

determination method or standard

1 reference

8 April 2019

High-throughput RNAi screening reveals novel regulators of telomerase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

protein autophosphorylation

determination method or standard

1 reference

10 September 2018

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IW41&geneProductId=UniProtKB:Q8IW41

determination method or standard

Ras protein signal transduction

determination method or standard

1 reference

24 April 2018

PRAK is essential for ras-induced senescence and tumor suppression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IW41&geneProductId=UniProtKB:Q8IW41

determination method or standard

regulation of translation

determination method or standard

1 reference

8 April 2019

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

signal transduction

determination method or standard

1 reference

8 April 2019

PRAK, a novel protein kinase regulated by the p38 MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

regulation of signal transduction by p53 class mediator

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

cell surface receptor signaling pathway

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IW41&geneProductId=UniProtKB:Q8IW41

determination method or standard

negative regulation of TOR signaling

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

intracellular signal transduction

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW41

determination method or standard

protein autophosphorylation

determination method or standard

serine/threonine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IW41

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IW41

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000449381

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449381

ENSP00000449667

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449667

ENSP00000448408

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000448408

ENSP00000473467

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000473467

ENSP00000473541

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000473541

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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