Dopamine receptor D5 (Q21131500)

http://www.ebi.ac.uk/interpro/protein/P21918

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21918&geneProductId=UniProtKB:P21918

1 reference

27 March 2018

dopamine binding

1 reference

27 March 2018

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21918&geneProductId=UniProtKB:P21918

dopamine neurotransmitter receptor activity, coupled via Gs

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

G-protein alpha-subunit binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21918&geneProductId=UniProtKB:P21918

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21918&geneProductId=UniProtKB:P21918

27 March 2018

27 March 2018

Differential dependence of the D1 and D5 dopamine receptors on the G protein gamma 7 subunit for activation of adenylylcyclase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21918&geneProductId=UniProtKB:P21918

27 March 2018

N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21918&geneProductId=UniProtKB:P21918

integral component of plasma membrane

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

8 April 2019

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

8 April 2019

brush border membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

ciliary membrane

1 reference

8 April 2019

DISC1 regulates primary cilia that display specific dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

non-motile cilium

1 reference

8 April 2019

DISC1 regulates primary cilia that display specific dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

intracellular anatomical structure

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21918&geneProductId=UniProtKB:P21918

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

8 April 2019

8 April 2019

Differential dependence of the D1 and D5 dopamine receptors on the G protein gamma 7 subunit for activation of adenylylcyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

8 April 2019

N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

cilium

1 reference

8 April 2019

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

biological process

response to cocaine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

cellular response to catecholamine stimulus

1 reference

8 April 2019

Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

regulation of female receptivity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

sensitization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

adenylate cyclase-activating dopamine receptor signaling pathway

associative learning

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

adenylate cyclase-activating G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

8 April 2019

Differential dependence of the D1 and D5 dopamine receptors on the G protein gamma 7 subunit for activation of adenylylcyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

negative regulation of blood pressure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

transmission of nerve impulse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

response to amphetamine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

regulation of systemic arterial blood pressure by vasopressin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

wound healing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

cellular calcium ion homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

mating behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

learning

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21918&geneProductId=UniProtKB:P21918

1 reference

27 March 2018

negative regulation of NAD(P)H oxidase activity

1 reference

8 April 2019

D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

activation of adenylate cyclase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

reactive oxygen species metabolic process

1 reference

8 April 2019

D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

phospholipase C-activating dopamine receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

long-term depression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

1 reference

8 April 2019

chemical synaptic transmission

1 reference

8 April 2019

The human dopamine D5 receptor gene: cloning and characterization of the 5'-flanking and promoter region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

synaptic transmission, dopaminergic

1 reference

8 April 2019

Dopamine D5 receptors of rat and human brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

G protein-coupled receptor signaling pathway

positive regulation of adenylate cyclase activity

1 reference

8 April 2019

The human dopamine D5 receptor gene: cloning and characterization of the 5'-flanking and promoter region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

adenylate cyclase-activating dopamine receptor signaling pathway

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

8 April 2019

Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21918

physically interacts with

1 reference

6077

17 August 2016

1 reference

5

17 August 2016

1 reference

988

17 August 2016

1 reference

35

17 August 2016

1 reference

37

17 August 2016

1 reference

940

17 August 2016

1 reference

48

17 August 2016

1 reference

941

17 August 2016

1 reference

33

17 August 2016

1 reference

43

17 August 2016

1 reference

935

17 August 2016

1 reference

62

17 August 2016

1 reference

83

17 August 2016

1 reference

38

17 August 2016

1 reference

3304

17 August 2016

1 reference

948

17 August 2016

1 reference

204

17 August 2016

1 reference

86

17 August 2016

1 reference

88

17 August 2016

2 references

943

English

17 August 2016

946

17 August 2016

1 reference

99

17 August 2016

1 reference

100

English

object of statement has role

17 August 2016

tavapadon

Partial agonist

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3697617

pimozide

object of statement has role

antagonist

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1423

pergolide mesylate

object of statement has role

agonist

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1275

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0