SET and MYND domain containing 2 (Q21127233)

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mammalian protein found in Homo sapiens

2.1.1.43
SET and MYND domain-containing protein 2
SMYD2
histone methyltransferase SMYD2
HSKM-B
N-lysine methyltransferase SMYD2
lysine N-methyltransferase 3C
zinc finger, MYND domain containing 14

Language	Label	Description	Also known as
English	SET and MYND domain containing 2	mammalian protein found in Homo sapiens	2.1.1.43 SET and MYND domain-containing protein 2 SMYD2 histone methyltransferase SMYD2 HSKM-B N-lysine methyltransferase SMYD2 lysine N-methyltransferase 3C zinc finger, MYND domain containing 14

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Tetratricopeptide-like helical domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NRG4

Zinc finger, MYND-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

SET domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

methyltransferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

transferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

determination method or standard

1 reference

8 April 2019

Repression of p53 activity by Smyd2-mediated methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

protein binding

determination method or standard

5 references

8 April 2019

SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

8 April 2019

Methylation of the retinoblastoma tumor suppressor by SMYD2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

8 April 2019

p53 is regulated by the lysine demethylase LSD1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

8 April 2019

Structural basis of substrate methylation and inhibition of SMYD2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

lysine N-methyltransferase activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

histone-lysine N-methyltransferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

determination method or standard

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

8 April 2019

SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

biological process

regulation of DNA damage response, signal transduction by p53 class mediator

determination method or standard

1 reference

8 April 2019

Repression of p53 activity by Smyd2-mediated methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NRG4&geneProductId=UniProtKB:Q9NRG4

determination method or standard

negative regulation of transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

Repression of p53 activity by Smyd2-mediated methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NRG4&geneProductId=UniProtKB:Q9NRG4

determination method or standard

histone H3-K36 methylation

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

heart development

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

histone methylation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

histone lysine methylation

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

regulation of signal transduction by p53 class mediator

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

chromatin organization

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRG4

determination method or standard

EC enzyme number

2.1.1.43

reason for deprecated rank

deprecated identifier value

1 reference

22 April 2020

2.1.1.354

1 reference

22 April 2020

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NRG4

Zinc finger, MYND-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NRG4

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000355924

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000355924

ENSP00000409822

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000409822

PDB structure ID

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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