Ubiquitin specific peptidase 14 (Q21126856)

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mammalian protein found in Homo sapiens

ubiquitin-specific processing protease 14
ubiquitin carboxyl-terminal hydrolase 14
deubiquitinating enzyme 14
tRNA-guanine transglycosylase, 60-kD subunit
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
ubiquitin thioesterase 14
ubiquitin specific protease 14 (tRNA-guanine transglycosylase)
Ubiquitin-specific-processing protease 14
USP14
ubiquitin thiolesterase 14

Language	Label	Description	Also known as
English	Ubiquitin specific peptidase 14	mammalian protein found in Homo sapiens	ubiquitin-specific processing protease 14 ubiquitin carboxyl-terminal hydrolase 14 deubiquitinating enzyme 14 tRNA-guanine transglycosylase, 60-kD subunit ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) ubiquitin thioesterase 14 ubiquitin specific protease 14 (tRNA-guanine transglycosylase) Ubiquitin-specific-processing protease 14 USP14 ubiquitin thiolesterase 14

Statements

1 reference

13 November 2019

UniProt protein ID

Ubiquitin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54578

Papain-like cysteine peptidase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54578

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Peptidase C19, ubiquitin carboxyl-terminal hydrolase family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin specific protease domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin specific protease, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

cysteine-type peptidase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

proteasome binding

determination method or standard

1 reference

8 April 2019

Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

peptidase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

protein binding

determination method or standard

3 references

8 April 2019

Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

8 April 2019

USP14 inhibits ER-associated degradation via interaction with IRE1alpha

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

8 April 2019

WITHDRAWN: USP14 stabilizes calcineurin and regulates NFAT/AP-1 dependent IL-4 transcription as a novel calcineurin-binding protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

cysteine-type endopeptidase activity

determination method or standard

1 reference

8 April 2019

Deubiquitinating enzymes: a new class of biological regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

endopeptidase inhibitor activity

determination method or standard

1 reference

8 April 2019

Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

hydrolase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

tRNA guanylyltransferase activity

determination method or standard

1 reference

8 April 2019

Cloning and characterization of cDNA encoding the rabbit tRNA-guanine transglycosylase 60-kilodalton subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

thiol-dependent deubiquitinase

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

8 April 2019

Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

plasma membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

determination method or standard

1 reference

8 April 2019

Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

proteasome complex

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

extracellular exosome

determination method or standard

1 reference

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54578&geneProductId=UniProtKB:P54578

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

cytoplasmic vesicle

determination method or standard

1 reference

8 April 2019

Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

determination method or standard

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54578&geneProductId=UniProtKB:P54578

determination method or standard

extracellular exosome

determination method or standard

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

biological process

regulation of proteasomal protein catabolic process

determination method or standard

1 reference

8 April 2019

Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

regulation of chemotaxis

determination method or standard

1 reference

8 April 2019

Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

ubiquitin-dependent protein catabolic process

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

negative regulation of ER-associated ubiquitin-dependent protein catabolic process

determination method or standard

1 reference

8 April 2019

USP14 inhibits ER-associated degradation via interaction with IRE1alpha

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

chemical synaptic transmission

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

negative regulation of endopeptidase activity

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

protein deubiquitination

determination method or standard

immune system process

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

innate immune response

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

tRNA 5'-end processing

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54578

determination method or standard

Ubiquitin domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54578

Peptidase C19, ubiquitin carboxyl-terminal hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54578

Ubiquitin specific protease, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54578

Ubiquitin specific protease domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54578

Ubiquitin conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54578

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000261601

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000261601

ENSP00000383125

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000383125

ENSP00000464447

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464447

ENSP00000373083

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373083

ENSP00000462315

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462315

ENSP00000463891

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463891

ENSP00000473563

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000473563

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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