Sirtuin 5 (Q21125222)

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mammalian protein found in Homo sapiens

NAD-dependent deacetylase sirtuin-5
SIRT5
Regulatory protein SIR2 homolog 5
NAD-dependent protein deacylase sirtuin-5, mitochondrial
sir2-like 5
silent mating type information regulation 2, S.cerevisiae, homolog 5
SIR2-like protein 5
NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
sirtuin type 5

Language	Label	Description	Also known as
English	Sirtuin 5	mammalian protein found in Homo sapiens	NAD-dependent deacetylase sirtuin-5 SIRT5 Regulatory protein SIR2 homolog 5 NAD-dependent protein deacylase sirtuin-5, mitochondrial sir2-like 5 silent mating type information regulation 2, S.cerevisiae, homolog 5 SIR2-like protein 5 NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial sirtuin type 5

Statements

1 reference

13 November 2019

UniProt protein ID

Sirtuin, class III

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NXA8

DHS-like NAD/FAD-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NXA8

Sirtuin, catalytic core small domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NXA8

Sirtuin family, catalytic core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

hydrolase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

NAD ADP-ribosyltransferase activity

determination method or standard

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

The first identification of lysine malonylation substrates and its regulatory enzyme

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

protein-succinyllysine desuccinylase activity

determination method or standard

8 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

The first identification of lysine malonylation substrates and its regulatory enzyme

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

SIRT5 desuccinylates and activates SOD1 to eliminate ROS

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

protein-malonyllysine demalonylase activity

determination method or standard

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

The first identification of lysine malonylation substrates and its regulatory enzyme

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

zinc ion binding

determination method or standard

1 reference

27 March 2018

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NXA8&geneProductId=UniProtKB:Q9NXA8

determination method or standard

NAD-dependent protein deacetylase activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

determination method or standard

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

mitochondrial matrix

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

mitochondrial inner membrane

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

biological process

negative regulation of cardiac muscle cell apoptotic process

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

response to nutrient levels

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

negative regulation of reactive oxygen species metabolic process

determination method or standard

1 reference

8 April 2019

SIRT5 desuccinylates and activates SOD1 to eliminate ROS

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

peptidyl-lysine deglutarylation

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

mitochondrion organization

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

peptidyl-lysine demalonylation

determination method or standard

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

The first identification of lysine malonylation substrates and its regulatory enzyme

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

protein desuccinylation

determination method or standard

4 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

SIRT5 desuccinylates and activates SOD1 to eliminate ROS

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

peptidyl-lysine desuccinylation

determination method or standard

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

8 April 2019

The first identification of lysine malonylation substrates and its regulatory enzyme

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8

determination method or standard

physically interacts with

determination method or standard

Affinity Capture-MS

1 reference

https://thebiogrid.org/news/227

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

Sirtuin family, catalytic core domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NXA8

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000352830

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000352830

ENSP00000368564

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000368564

ENSP00000380509

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380509

ENSP00000476228

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000476228

ENSP00000368552

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000368552

ENSP00000476211

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000476211

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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