Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma (Q21123236)

Ubiquitin-like domain superfamily

1 reference

Protein kinase-like domain superfamily

1 reference

C2 domain superfamily

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

1 reference

Phosphatidylinositol kinase family

1 reference

Armadillo-type fold

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family

1 reference

Phosphatidylinositol 3-kinase, C2 domain, protein family

1 reference

Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain, protein family

1 reference

Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain, protein family

1 reference

Phosphoinositide 3-kinase, accessory (PIK) domain, protein family

1 reference

Phosphatidylinositol 3/4-kinase, conserved site, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

1 reference

8 April 2019

protein kinase activity

1 reference

8 April 2019

Twice upon a time: PI3K's secret double life exposed

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

1 reference

8 April 2019

ephrin receptor binding

1 reference

8 April 2019

The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

1-phosphatidylinositol-4-phosphate 3-kinase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

1 reference

8 April 2019

protein binding

4 references

8 April 2019

PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

8 April 2019

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

8 April 2019

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

8 April 2019

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

phosphatidylinositol 3-kinase activity

1 reference

8 April 2019

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

1 reference

8 April 2019

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48736&geneProductId=UniProtKB:P48736

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48736&geneProductId=UniProtKB:P48736

1 January 2018

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48736&geneProductId=UniProtKB:P48736

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

8 April 2019

8 April 2019

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

1-phosphatidylinositol-3-kinase activity

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

phosphatidylinositol-3,4-bisphosphate 5-kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

1 reference

8 April 2019

phosphatidylinositol 3-kinase complex

cell component

1 reference

24 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48736&geneProductId=UniProtKB:P48736

membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48736&geneProductId=UniProtKB:P48736

3 references

24 October 2017

24 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48736&geneProductId=UniProtKB:P48736

24 October 2017

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48736&geneProductId=UniProtKB:P48736

phosphatidylinositol 3-kinase complex, class IB

1 reference

24 October 2017

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48736&geneProductId=UniProtKB:P48736

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

1 reference

8 April 2019

mast cell granule

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

3 references

8 April 2019

8 April 2019

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

phosphatidylinositol 3-kinase complex, class IB

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

4 references

8 April 2019

8 April 2019

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

8 April 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

regulation of protein phosphorylation

HDA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

G protein-coupled receptor signaling pathway

positive regulation of protein kinase B signaling

1 reference

8 April 2019

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

regulation of cell adhesion mediated by integrin

1 reference

8 April 2019

Targeting phosphoinositide 3-kinase gamma to fight inflammation and more

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

1 reference

8 April 2019

adaptive immune response

1 reference

8 April 2019

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

respiratory burst involved in defense response

1 reference

8 April 2019

Isoform selective phosphoinositide 3-kinase gamma and delta inhibitors and their therapeutic potential

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

positive regulation of MAP kinase activity

1 reference

8 April 2019

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

1 reference

8 April 2019

positive regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

T cell chemotaxis

1 reference

8 April 2019

Targeting phosphoinositide 3-kinase gamma to fight inflammation and more

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

cytokine production

1 reference

8 April 2019

Isoform selective phosphoinositide 3-kinase gamma and delta inhibitors and their therapeutic potential

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

positive regulation of catalytic activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

secretory granule localization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

dendritic cell chemotaxis

1 reference

8 April 2019

Targeting phosphoinositide 3-kinase gamma to fight inflammation and more

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

neutrophil chemotaxis

1 reference

8 April 2019

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

platelet activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48736&geneProductId=UniProtKB:P48736

1 reference

24 October 2017

T cell proliferation

1 reference

8 April 2019

Isoform selective phosphoinositide 3-kinase gamma and delta inhibitors and their therapeutic potential

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

1 reference

8 April 2019

protein phosphorylation

1 reference

24 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48736&geneProductId=UniProtKB:P48736

phosphatidylinositol-3-phosphate biosynthetic process

1 reference

24 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48736&geneProductId=UniProtKB:P48736

natural killer cell chemotaxis

1 reference

8 April 2019

Targeting phosphoinositide 3-kinase gamma to fight inflammation and more

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

1 reference

8 April 2019

positive regulation of acute inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

phosphatidylinositol biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

1 reference

8 April 2019

negative regulation of fibroblast apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

phosphatidylinositol 3-kinase signaling

negative regulation of triglyceride catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

mast cell degranulation

1 reference

8 April 2019

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

innate immune response

1 reference

8 April 2019

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

platelet aggregation

1 reference

8 April 2019

Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

neutrophil extravasation

1 reference

8 April 2019

Targeting phosphoinositide 3-kinase gamma to fight inflammation and more

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

T cell activation

1 reference

8 April 2019

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

regulation of calcium ion transmembrane transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

cellular response to cAMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

hepatocyte apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

phosphatidylinositol-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48736&geneProductId=UniProtKB:P48736

1 reference

24 October 2017

negative regulation of cardiac muscle contraction

1 reference

8 April 2019

Cardiac regulation by phosphoinositide 3-kinases and PTEN

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

phosphatidylinositol 3-kinase signaling

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

8 April 2019

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

positive regulation of phosphatidylinositol 3-kinase signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

1 reference

8 April 2019

cell migration

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

phosphatidylinositol-3-phosphate biosynthetic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48736

phosphatidylinositol phosphate biosynthetic process

physically interacts with

3 references

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7950

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

6741

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

6004

English

17 August 2016

buparlisib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2017974

apitolisib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1922094

AZD6482

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2165191

BGT-226

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3218578

ch-5132799

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1684984

duvelisib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3039502

gedatolisib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL592445

omipalisib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1236962

pf-04691502

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1234354

pictilisib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL521851

sonolisib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL411907

taselisib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2387080

tg-100115

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL230011

zstk-474

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL586702

EC enzyme number

2.7.11.1

1 reference

15 November 2015

http://www.uniprot.org/uniprot/P48736.txt?version=163

has part(s)

Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain

1 reference

Phosphoinositide 3-kinase, accessory (PIK) domain

1 reference

Phosphatidylinositol 3/4-kinase, conserved site

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain

1 reference

Phosphatidylinositol 3-kinase, C2 domain

1 reference

Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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13 November 2019

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9 August 2016

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