NK3 homeobox 1 (Q21123125)

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox domain, metazoa, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

sequence-specific DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

3 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

1 January 2018

Interactions of the acidic domain and SRF interacting motifs with the NKX3.1 homeodomain

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

DNA binding

DNA-binding transcription factor activity

Full-length cDNA sequence and genomic organization of human NKX3A - alternative forms and regulation by both androgens and estrogens

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

1 January 2018

NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

histone deacetylase binding

1 reference

8 April 2019

Loss of NKX3.1 favors vascular endothelial growth factor-C expression in prostate cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

transcription cis-regulatory region binding

1 reference

8 April 2019

NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

RNA polymerase II general transcription initiation factor activity

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

estrogen receptor activity

1 reference

8 April 2019

Nkx3-1 and LEF-1 function as transcriptional inhibitors of estrogen receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

protein kinase activator activity

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

protein self-association

1 reference

8 April 2019

Interactions of the acidic domain and SRF interacting motifs with the NKX3.1 homeodomain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

MADS box domain binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

protein binding

4 references

8 April 2019

Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

Structural and functional analysis of domains mediating interaction between the bagpipe homologue, Nkx3.1 and serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

NKX3.1 homeodomain protein binds to topoisomerase I and enhances its activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

cysteine-type endopeptidase activator activity involved in apoptotic process

1 reference

8 April 2019

Nkx3.1 and p27(KIP1) cooperate in proliferation inhibition and apoptosis induction in human androgen-independent prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

estrogen receptor binding

1 reference

8 April 2019

Nkx3-1 and LEF-1 function as transcriptional inhibitors of estrogen receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

DNA-binding transcription factor activity, RNA polymerase II-specific

A census of human transcription factors: function, expression and evolution

3 references

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

NAS

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

Norwegian University of Science and Technology, Systems Biology team

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

RNA polymerase II cis-regulatory region sequence-specific DNA binding

ISA

1 reference

1 January 2018

Loss of NKX3.1 favors vascular endothelial growth factor-C expression in prostate cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

nuclear receptor activity

1 reference

8 April 2019

Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity

Full-length cDNA sequence and genomic organization of human NKX3A - alternative forms and regulation by both androgens and estrogens

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

sequence-specific DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

Interactions of the acidic domain and SRF interacting motifs with the NKX3.1 homeodomain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

cell component

nucleus

Full-length cDNA sequence and genomic organization of human NKX3A - alternative forms and regulation by both androgens and estrogens

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

1 January 2018

Inflammatory cytokines induce phosphorylation and ubiquitination of prostate suppressor protein NKX3.1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

1 January 2018

Identification of Sp1-elements in the promoter region of human homeobox gene NKX3.1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

1 January 2018

NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

intracellular anatomical structure

IC

1 reference

1 January 2018

Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

site of DNA damage

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

nucleus

Full-length cDNA sequence and genomic organization of human NKX3A - alternative forms and regulation by both androgens and estrogens

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

Inflammatory cytokines induce phosphorylation and ubiquitination of prostate suppressor protein NKX3.1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

Identification of Sp1-elements in the promoter region of human homeobox gene NKX3.1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

IC

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

biological process

somitogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

androgen receptor signaling pathway

1 reference

8 April 2019

Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

cellular response to steroid hormone stimulus

1 reference

8 April 2019

Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

dorsal aorta development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

positive regulation of protein phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

male gonad development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

positive regulation of cell death

1 reference

8 April 2019

Nkx3.1 and p27(KIP1) cooperate in proliferation inhibition and apoptosis induction in human androgen-independent prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

cellular response to tumor necrosis factor

1 reference

8 April 2019

Inflammatory cytokines induce phosphorylation and ubiquitination of prostate suppressor protein NKX3.1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

positive regulation of androgen secretion

1 reference

8 April 2019

Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

positive regulation of mitotic cell cycle

1 reference

8 April 2019

NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

positive regulation of apoptotic signaling pathway

1 reference

8 April 2019

NKX3.1 potentiates TNF-alpha/CHX-induced apoptosis of prostate cancer cells through increasing caspase-3 expression and its activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

prostate gland development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

negative regulation of gene expression

1 reference

8 April 2019

Expression of Nkx3.1 enhances 17beta-estradiol anti-tumor action in PC3 human prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

1 reference

5 June 2018

multicellular organism development

TAS

1 reference

8 April 2019

Isolation and androgen regulation of the human homeobox cDNA, NKX3.1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

positive regulation of transcription, DNA-templated

TAS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

3 references

8 April 2019

ISS

8 April 2019

Functional analysis of NKX3.1 in LNCaP prostate cancer cells by RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

heart development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

NKX3.1 potentiates TNF-alpha/CHX-induced apoptosis of prostate cancer cells through increasing caspase-3 expression and its activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

positive regulation of gene expression

A functional variant in NKX3.1 associated with prostate cancer susceptibility down-regulates NKX3.1 expression

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

Expression of Nkx3.1 enhances 17beta-estradiol anti-tumor action in PC3 human prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

NKX3.1 potentiates TNF-alpha/CHX-induced apoptosis of prostate cancer cells through increasing caspase-3 expression and its activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

positive regulation of response to DNA damage stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

positive regulation of cell population proliferation

1 reference

8 April 2019

Functional analysis of NKX3.1 in LNCaP prostate cancer cells by RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

cellular response to interleukin-1

1 reference

8 April 2019

Inflammatory cytokines induce phosphorylation and ubiquitination of prostate suppressor protein NKX3.1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

urogenital system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

metanephros development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

negative regulation of transcription, DNA-templated

Functional analysis of NKX3.1 in LNCaP prostate cancer cells by RNA interference

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

Loss of NKX3.1 favors vascular endothelial growth factor-C expression in prostate cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

Nkx3-1 and LEF-1 function as transcriptional inhibitors of estrogen receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of intrinsic apoptotic signaling pathway

1 reference

8 April 2019

Expression of Nkx3.1 enhances 17beta-estradiol anti-tumor action in PC3 human prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

positive regulation of cell division

1 reference

8 April 2019

NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

cellular response to hypoxia

1 reference

8 April 2019

Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

positive regulation of transcription by RNA polymerase II

2 references

1 January 2018

Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

1 January 2018

NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

negative regulation of cell population proliferation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

Expression of Nkx3.1 enhances 17beta-estradiol anti-tumor action in PC3 human prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

Nkx3.1 and p27(KIP1) cooperate in proliferation inhibition and apoptosis induction in human androgen-independent prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

negative regulation of mitotic cell cycle

1 reference

8 April 2019

Nkx3.1 and p27(KIP1) cooperate in proliferation inhibition and apoptosis induction in human androgen-independent prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

pharyngeal system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

activation of protein kinase activity

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99801&geneProductId=UniProtKB:Q99801

regulation of protein localization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

positive regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

cell differentiation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

positive regulation of transcription by RNA polymerase II

Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99801

1 reference

Homeobox, conserved site

1 reference

Homeobox domain, metazoa

1 reference