Melatonin receptor 1A (Q21122995)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48039

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.1.3

hierarchical database ID heuristic

2 October 2019

based on heuristic

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48039

organic cyclic compound binding

IPI

1 reference

8 April 2019

Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48039

signal transducer activity

IPI

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48039&geneProductId=UniProtKB:P48039

4 references

8 April 2019

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48039

8 April 2019

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48039

8 April 2019

Purification and identification of G protein-coupled receptor protein complexes under native conditions.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48039

8 April 2019

Molecular organization and dynamics of the melatonin MT₁ receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) coupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48039

melatonin receptor activity

IPI

3 references

5 June 2018

Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48039&geneProductId=UniProtKB:P48039

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48039&geneProductId=UniProtKB:P48039

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48039&geneProductId=UniProtKB:P48039

melatonin receptor activity

IBA

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48039&geneProductId=UniProtKB:P48039

21 June 2018

Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48039&geneProductId=UniProtKB:P48039

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48039&geneProductId=UniProtKB:P48039

G protein-coupled receptor activity

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48039

1 reference

8 April 2019

Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48039

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

8 April 2019

Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48039

1 reference

8 April 2019

Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48039

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48039

1 reference

21 June 2018

Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48039&geneProductId=UniProtKB:P48039

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

TAS

1 reference

8 April 2019

Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48039

physically interacts with

1 reference

1347

17 August 2016

1 reference

198

17 August 2016

1 reference

1349

17 August 2016

1 reference

1351

17 August 2016

1 reference

224

17 August 2016

1 reference

1356

17 August 2016

1 reference

7393

17 August 2016

1 reference

1363

English

object of statement has role

17 August 2016

melatonin

agonist

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL45

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48039

Identifiers

MeSH descriptor ID

D044122

subject named as

Receptor, Melatonin, MT1

0 references

MeSH tree code

D12.776.543.750.695.440.500

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

Transporter Classification Database ID

9.A.14.1.3

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023