Alanine--glyoxylate and serine--pyruvate aminotransferase (Q21122112)

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mammalian protein found in Homo sapiens

AGXT
alanine-glyoxylate aminotransferase
hepatic peroxisomal alanine:glyoxylate aminotransferase
L-alanine: glyoxylate aminotransferase 1
serine--pyruvate aminotransferase
AGT
2.6.1.44
Alanine--glyoxylate aminotransferase

Language	Label	Description	Also known as
English	Alanine--glyoxylate and serine--pyruvate aminotransferase	mammalian protein found in Homo sapiens	AGXT alanine-glyoxylate aminotransferase hepatic peroxisomal alanine:glyoxylate aminotransferase L-alanine: glyoxylate aminotransferase 1 serine--pyruvate aminotransferase AGT 2.6.1.44 Alanine--glyoxylate aminotransferase

Statements

1 reference

13 November 2019

UniProt protein ID

Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21549

Pyridoxal phosphate-dependent transferase, major domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21549

Pyridoxal phosphate-dependent transferase domain 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21549

Pyridoxal phosphate-dependent transferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21549

Aminotransferase class V domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aminotransferase class-V, pyridoxal-phosphate binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

protein homodimerization activity

determination method or standard

3 references

8 April 2019

Consequences of missense mutations for dimerization and turnover of alanine:glyoxylate aminotransferase: study of a spectrum of mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Molecular defects of the glycine 41 variants of alanine glyoxylate aminotransferase associated with primary hyperoxaluria type I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

alanine-glyoxylate transaminase activity

determination method or standard

8 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21549&geneProductId=UniProtKB:P21549

determination method or standard

24 April 2018

Human peroxisomal L-alanine: glyoxylate aminotransferase. Evolutionary loss of a mitochondrial targeting signal by point mutation of the initiation codon

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21549&geneProductId=UniProtKB:P21549

determination method or standard

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21549&geneProductId=UniProtKB:P21549

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21549&geneProductId=UniProtKB:P21549

determination method or standard

24 April 2018

Human wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21549&geneProductId=UniProtKB:P21549

determination method or standard

24 April 2018

The N-terminal extension is essential for the formation of the active dimeric structure of liver peroxisomal alanine:glyoxylate aminotransferase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21549&geneProductId=UniProtKB:P21549

determination method or standard

24 April 2018

Consequences of missense mutations for dimerization and turnover of alanine:glyoxylate aminotransferase: study of a spectrum of mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21549&geneProductId=UniProtKB:P21549

determination method or standard

24 April 2018

Reactions of human liver peroxisomal alanine:glyoxylate aminotransferase with beta-chloro-L-alanine and L-cysteine: spectroscopic and kinetic analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21549&geneProductId=UniProtKB:P21549

determination method or standard

serine-pyruvate transaminase activity

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

transaminase activity

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Molecular defects of the glycine 41 variants of alanine glyoxylate aminotransferase associated with primary hyperoxaluria type I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Reactions of human liver peroxisomal alanine:glyoxylate aminotransferase with beta-chloro-L-alanine and L-cysteine: spectroscopic and kinetic analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

protein self-association

determination method or standard

1 reference

8 April 2019

Consequences of missense mutations for dimerization and turnover of alanine:glyoxylate aminotransferase: study of a spectrum of mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

catalytic activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

protein binding

determination method or standard

2 references

8 April 2019

Molecular Requirements for Peroxisomal Targeting of Alanine-Glyoxylate Aminotransferase as an Essential Determinant in Primary Hyperoxaluria Type 1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Peroxisomal import of human alanine:glyoxylate aminotransferase requires ancillary targeting information remote from its C terminus

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

pyridoxal phosphate binding

determination method or standard

3 references

8 April 2019

Overexpression of human alanine:glyoxylate aminotransferase in Escherichia coli: renaturation from guanidine-HCl and affinity for pyridoxal phosphate co-factor

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Molecular defects of the glycine 41 variants of alanine glyoxylate aminotransferase associated with primary hyperoxaluria type I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Human wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

signaling receptor binding

determination method or standard

1 reference

8 April 2019

A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

identical protein binding

determination method or standard

1 reference

8 April 2019

Molecular Requirements for Peroxisomal Targeting of Alanine-Glyoxylate Aminotransferase as an Essential Determinant in Primary Hyperoxaluria Type 1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

alanine-glyoxylate transaminase activity

determination method or standard

8 references

8 April 2019

Human peroxisomal L-alanine: glyoxylate aminotransferase. Evolutionary loss of a mitochondrial targeting signal by point mutation of the initiation codon

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

The N-terminal extension is essential for the formation of the active dimeric structure of liver peroxisomal alanine:glyoxylate aminotransferase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Consequences of missense mutations for dimerization and turnover of alanine:glyoxylate aminotransferase: study of a spectrum of mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Reactions of human liver peroxisomal alanine:glyoxylate aminotransferase with beta-chloro-L-alanine and L-cysteine: spectroscopic and kinetic analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Human wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

determination method or standard

6 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21549&geneProductId=UniProtKB:P21549

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21549&geneProductId=UniProtKB:P21549

determination method or standard

24 April 2018

Immunocytochemical localization of peroxisomal proteins in human liver and kidney

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21549&geneProductId=UniProtKB:P21549

determination method or standard

24 April 2018

Peroxisomal alanine:glyoxylate aminotransferase deficiency in primary hyperoxaluria type I

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21549&geneProductId=UniProtKB:P21549

determination method or standard

24 April 2018

Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21549&geneProductId=UniProtKB:P21549

determination method or standard

24 April 2018

Evolution of alanine:glyoxylate aminotransferase 1 peroxisomal and mitochondrial targeting. A survey of its subcellular distribution in the livers of various representatives of the classes Mammalia, Aves and Amphibia

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21549&geneProductId=UniProtKB:P21549

determination method or standard

mitochondrial matrix

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

peroxisomal matrix

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

The N-terminal extension is essential for the formation of the active dimeric structure of liver peroxisomal alanine:glyoxylate aminotransferase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Immunocytochemical localization of human hepatic alanine: glyoxylate aminotransferase in control subjects and patients with primary hyperoxaluria type 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

intracellular membrane-bounded organelle

determination method or standard

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

determination method or standard

7 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Immunocytochemical localization of peroxisomal proteins in human liver and kidney

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Evolution of alanine:glyoxylate aminotransferase 1 peroxisomal and mitochondrial targeting. A survey of its subcellular distribution in the livers of various representatives of the classes Mammalia, Aves and Amphibia

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Peroxisomal alanine:glyoxylate aminotransferase deficiency in primary hyperoxaluria type I

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

biological process

Notch signaling pathway

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

oxalic acid secretion

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

glyoxylate catabolic process

determination method or standard

1 reference

8 April 2019

The N-terminal extension is essential for the formation of the active dimeric structure of liver peroxisomal alanine:glyoxylate aminotransferase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

glycine biosynthetic process, by transamination of glyoxylate

determination method or standard

pyruvate biosynthetic process

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

L-alanine catabolic process

determination method or standard

3 references

8 April 2019

The N-terminal extension is essential for the formation of the active dimeric structure of liver peroxisomal alanine:glyoxylate aminotransferase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Reactions of human liver peroxisomal alanine:glyoxylate aminotransferase with beta-chloro-L-alanine and L-cysteine: spectroscopic and kinetic analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Human wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

response to glucocorticoid

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

response to cAMP

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

L-cysteine catabolic process

determination method or standard

1 reference

8 April 2019

Reactions of human liver peroxisomal alanine:glyoxylate aminotransferase with beta-chloro-L-alanine and L-cysteine: spectroscopic and kinetic analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

cellular nitrogen compound metabolic process

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

protein targeting to peroxisome

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

glycine biosynthetic process, by transamination of glyoxylate

determination method or standard

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

The N-terminal extension is essential for the formation of the active dimeric structure of liver peroxisomal alanine:glyoxylate aminotransferase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21549

determination method or standard

EC enzyme number

2.6.1.44

1 reference

6 January 2016

http://www.uniprot.org/uniprot/P21549.txt?version=158

Aminotransferase class-V, pyridoxal-phosphate binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21549

Aminotransferase class V domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21549

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000302620

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000302620

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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