CCAAT enhancer binding protein alpha (Q21116819)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49715

Basic-leucine zipper domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

sequence-specific DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

DNA-binding transcription factor activity

Transcription factor C/EBPalpha: novel sites of expression and cloning of the human gene

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HG

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49715&geneProductId=UniProtKB:P49715

transcription factor binding

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

protein binding

6 references

8 April 2019

Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

Homeodomain transcription factor CDX1 is required for the transcriptional induction of PPARgamma in intestinal cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

The Papillomavirus E2 protein binds to and synergizes with C/EBP factors involved in keratinocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

Interleukin (IL)-32β-mediated CCAAT/enhancer-binding protein α (C/EBPα) phosphorylation by protein kinase Cδ (PKCδ) abrogates the inhibitory effect of C/EBPα on IL-10 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

In prostate cancer cells the interaction of C/EBPalpha with Ku70, Ku80, and poly(ADP-ribose) polymerase-1 increases sensitivity to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

DNA-binding transcription factor activity, RNA polymerase II-specific

Norwegian University of Science and Technology, Systems Biology team

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49715&geneProductId=UniProtKB:P49715

DNA-binding transcription factor activity, RNA polymerase II-specific

ISA

Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha)

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

Norwegian University of Science and Technology, Systems Biology team

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

transcription regulator complex

cell component

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49715&geneProductId=UniProtKB:P49715

RNA polymerase II transcription regulator complex

IMP

1 reference

8 April 2019

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

IMP

nucleus

Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha)

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

1 reference

8 April 2019

intracellular membrane-bounded organelle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

1 reference

8 April 2019

nucleolus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

1 reference

8 April 2019

biological process

Notch signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

transcription by RNA polymerase I

1 reference

27 March 2018

Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49715&geneProductId=UniProtKB:P49715

myeloid cell differentiation

cellular response to lithium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

negative regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

8 April 2019

Roles of CHOP/GADD153 in endoplasmic reticulum stress

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

cytokine-mediated signaling pathway

1 reference

8 April 2019

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

urea cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

cellular response to organic cyclic compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

mitochondrion organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

embryonic placenta development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

cholesterol metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

negative regulation of cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

cell maturation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

generation of precursor metabolites and energy

1 reference

8 April 2019

The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

transcription, DNA-templated

Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha)

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49715&geneProductId=UniProtKB:P49715

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49715&geneProductId=UniProtKB:P49715

27 March 2018

27 March 2018

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49715&geneProductId=UniProtKB:P49715

macrophage differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

1 reference

8 April 2019

positive regulation of transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

positive regulation of osteoblast differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

brown fat cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

white fat cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

inner ear development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

1 reference

8 April 2019

positive regulation of fat cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

positive regulation of transcription by RNA polymerase III

1 reference

8 April 2019

Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Roles of CHOP/GADD153 in endoplasmic reticulum stress

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

positive regulation of transcription by RNA polymerase II

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49715&geneProductId=UniProtKB:P49715

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49715&geneProductId=UniProtKB:P49715

1 January 2018

NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49715&geneProductId=UniProtKB:P49715

1 January 2018

Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49715&geneProductId=UniProtKB:P49715

negative regulation of cell population proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

transcription by RNA polymerase II

1 reference

8 April 2019

The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

cellular response to tumor necrosis factor

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

positive regulation of DNA-templated transcription, initiation

1 reference

27 March 2018

EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49715&geneProductId=UniProtKB:P49715

transcription, DNA-templated

Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha)

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

positive regulation of transcription by RNA polymerase II

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

IMP

8 April 2019

Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

8 April 2019

Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

interleukin-6-mediated signaling pathway

1 reference

8 April 2019

Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49715

Basic-leucine zipper domain

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49715

Identifiers

MeSH descriptor ID

D022763

subject named as

CCAAT-Enhancer-Binding Protein-alpha

0 references

MeSH tree code

D12.776.260.108.124.500

0 references

D12.776.660.167.500

0 references

D12.776.930.127.124.500

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023