STIP1 homology and U-box containing protein 1 (Q21116753)

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mammalian protein found in Homo sapiens
  • RING-type E3 ubiquitin transferase CHIP
  • heat shock protein A binding protein 2 (c-terminal)
  • STIP1 homology and U box-containing protein 1
  • serologically defined colon cancer antigen 7
  • E3 ubiquitin-protein ligase CHIP
  • antigen NY-CO-7
  • carboxy terminus of Hsp70-interacting protein
  • STUB1
  • STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
  • CLL-associated antigen KW-8
  • STUB1 protein, human
  • CHIP
  • Carboxyl terminus of Hsc70-interacting protein
edit
Language Label Description Also known as
English
STIP1 homology and U-box containing protein 1
mammalian protein found in Homo sapiens
  • RING-type E3 ubiquitin transferase CHIP
  • heat shock protein A binding protein 2 (c-terminal)
  • STIP1 homology and U box-containing protein 1
  • serologically defined colon cancer antigen 7
  • E3 ubiquitin-protein ligase CHIP
  • antigen NY-CO-7
  • carboxy terminus of Hsp70-interacting protein
  • STUB1
  • STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
  • CLL-associated antigen KW-8
  • STUB1 protein, human
  • CHIP
  • Carboxyl terminus of Hsc70-interacting protein

Statements

molecular function
protein binding
determination method or standard
IPI
31 references
retrieved
8 April 2019
stated in
Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels
GOA
curator
UniProt
UniProt protein ID
Q9UNE7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.
GOA
curator
UniProt
UniProt protein ID
Q9UNE7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1
GOA
curator
UniProt
UniProt protein ID
Q9UNE7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding
GOA
curator
UniProt
UniProt protein ID
Q9UNE7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
GOA
curator
UniProt
UniProt protein ID
Q9UNE7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia
GOA
curator
UniProt
UniProt protein ID
Q9UNE7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy
GOA
curator
UniProt
UniProt protein ID
Q9UNE7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Global landscape of HIV-human protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
CHIP interacts with heat shock factor 1 during heat stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
retrieved
8 April 2019
stated in
BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IPI
ubiquitin protein ligase activity
determination method or standard
IDA
IEA
IMP
TAS
7 references
retrieved
17 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UNE7&geneProductId=UniProtKB:Q9UNE7
determination method or standard
TAS
retrieved
17 October 2017
stated in
Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UNE7&geneProductId=UniProtKB:Q9UNE7
determination method or standard
IMP
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UNE7&geneProductId=UniProtKB:Q9UNE7
determination method or standard
IEA
retrieved
17 October 2017
stated in
Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1
GOA
curator
UniProt
UniProt protein ID
Q9UNE7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UNE7&geneProductId=UniProtKB:Q9UNE7
determination method or standard
IDA
retrieved
17 October 2017
stated in
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UNE7&geneProductId=UniProtKB:Q9UNE7
determination method or standard
IDA
retrieved
17 October 2017
stated in
CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UNE7&geneProductId=UniProtKB:Q9UNE7
determination method or standard
IDA
retrieved
17 October 2017
stated in
Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UNE7&geneProductId=UniProtKB:Q9UNE7
determination method or standard
IDA
ubiquitin protein ligase activity
determination method or standard
IDA
IEA
IGI
IMP
TAS
10 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
TAS
retrieved
8 April 2019
stated in
Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IMP
retrieved
8 April 2019
stated in
Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IMP
retrieved
8 April 2019
stated in
BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IEA
retrieved
8 April 2019
stated in
Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1
GOA
curator
UniProt
UniProt protein ID
Q9UNE7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IDA
retrieved
8 April 2019
stated in
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IDA
retrieved
8 April 2019
stated in
CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IDA
retrieved
8 April 2019
stated in
Dimerization of the human E3 ligase CHIP via a coiled-coil domain is essential for its activity.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IDA
retrieved
8 April 2019
stated in
Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IDA
cell component
biological process
protein ubiquitination
determination method or standard
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.
GOA
curator
UniProt
UniProt protein ID
Q9UNE7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IMP
retrieved
8 April 2019
stated in
Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UNE7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IEA
retrieved
8 April 2019
stated in
Dimerization of the human E3 ligase CHIP via a coiled-coil domain is essential for its activity.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IDA
retrieved
8 April 2019
stated in
Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IDA
proteasome-mediated ubiquitin-dependent protein catabolic process
determination method or standard
IDA
IEA
IMP
TAS
5 references
retrieved
8 April 2019
stated in
Brain distribution of carboxy terminus of Hsc70-interacting protein (CHIP) and its nuclear translocation in cultured cortical neurons following heat stress or oxygen-glucose deprivation.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
TAS
retrieved
8 April 2019
stated in
PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.
GOA
curator
UniProt
UniProt protein ID
Q9UNE7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IEA
retrieved
8 April 2019
stated in
Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1
GOA
curator
UniProt
UniProt protein ID
Q9UNE7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IDA
retrieved
8 April 2019
stated in
CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNE7
determination method or standard
IDA

Identifiers

MeSH descriptor ID
C467728
subject named as
STUB1 protein, human
0 references
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21116753&oldid=2022967673"