X-ray repair cross complementing 5 (Q21116582)

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mammalian protein found in Homo sapiens
  • nuclear factor IV
  • Ku86 autoantigen related protein 1
  • Ku autoantigen, 80kDa
  • thyroid-lupus autoantigen
  • CTC box-binding factor 85 kDa subunit
  • CTCBF
  • Ku86
  • 86 kDa subunit of Ku antigen
  • TLAA
  • X-ray repair cross-complementing protein 5
  • lupus Ku autoantigen protein p86
  • ATP-dependent DNA helicase II 80 kDa subunit
  • Ku80
  • XRCC5
  • CTC85
  • DNA repair protein XRCC5
  • X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
  • ATP-dependent DNA helicase 2 subunit 2
edit
Language Label Description Also known as
English
X-ray repair cross complementing 5
mammalian protein found in Homo sapiens
  • nuclear factor IV
  • Ku86 autoantigen related protein 1
  • Ku autoantigen, 80kDa
  • thyroid-lupus autoantigen
  • CTC box-binding factor 85 kDa subunit
  • CTCBF
  • Ku86
  • 86 kDa subunit of Ku antigen
  • TLAA
  • X-ray repair cross-complementing protein 5
  • lupus Ku autoantigen protein p86
  • ATP-dependent DNA helicase II 80 kDa subunit
  • Ku80
  • XRCC5
  • CTC85
  • DNA repair protein XRCC5
  • X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
  • ATP-dependent DNA helicase 2 subunit 2

Statements

molecular function
protein binding
determination method or standard
IPI
36 references
retrieved
8 April 2019
stated in
The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN.
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Heat shock factor 1, an inhibitor of non-homologous end joining repair
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
A role for the HOXB7 homeodomain protein in DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA- dependent protein kinase complex in an isoform-dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Aire's partners in the molecular control of immunological tolerance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
APLF promotes the assembly and activity of non-homologous end joining protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role of the translationally controlled tumor protein in DNA damage sensing and repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Coilin interacts with Ku proteins and inhibits in vitro non‐homologous DNA end joining
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
A role of DNA-PK for the metabolic gene regulation in response to insulin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human Ku70/80 associates physically with telomerase through interaction with hTERT
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
retrieved
8 April 2019
stated in
TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IPI
cell component
Ku70:Ku80 complex
determination method or standard
IBA
IDA
IEA
TAS
6 references
retrieved
8 April 2019
stated in
Impaired telomerase activity in human cells expressing GFP-Ku86 fusion proteins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IEA
retrieved
8 April 2019
stated in
Heat shock factor 1, an inhibitor of non-homologous end joining repair
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IDA
retrieved
8 April 2019
stated in
Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IDA
retrieved
8 April 2019
stated in
TRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeres
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IBA
biological process
double-strand break repair via nonhomologous end joining
determination method or standard
IBA
IDA
IEA
IMP
TAS
6 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
TAS
retrieved
8 April 2019
stated in
Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
TAS
retrieved
8 April 2019
stated in
Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IEA
retrieved
8 April 2019
stated in
Heat shock factor 1, an inhibitor of non-homologous end joining repair
GOA
curator
UniProt
UniProt protein ID
P13010
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13010
determination method or standard
IBA

Identifiers

 
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