Siah E3 ubiquitin protein ligase 1 (Q21116389)

E3 ubiquitin-protein ligase SIN-like

1 reference

Zinc finger, RING/FYVE/PHD-type

1 reference

Seven-in-absentia protein, TRAF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, SIAH-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

1 reference

8 April 2019

identical protein binding

3 references

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

ubiquitin protein ligase activity

1 reference

21 June 2018

Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUQ4&geneProductId=UniProtKB:Q8IUQ4

protein binding

11 references

8 April 2019

Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

E3 ubiquitin ligase Siah-1 facilitates poly-ubiquitylation and proteasomal degradation of the hepatitis B viral X protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

ARTS and Siah collaborate in a pathway for XIAP degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

Next-generation sequencing to generate interactome datasets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

Regulation of BOB.1/OBF.1 stability by SIAH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

zinc ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

8 April 2019

An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

1 reference

8 April 2019

ubiquitin-protein transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUQ4&geneProductId=UniProtKB:Q8IUQ4

5 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUQ4&geneProductId=UniProtKB:Q8IUQ4

10 September 2018

ISS

10 September 2018

ARTS and Siah collaborate in a pathway for XIAP degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUQ4&geneProductId=UniProtKB:Q8IUQ4

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUQ4&geneProductId=UniProtKB:Q8IUQ4

10 September 2018

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUQ4&geneProductId=UniProtKB:Q8IUQ4

ubiquitin conjugating enzyme binding

EXP

IBA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

ubiquitin-protein transferase activity

IBA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

ISS

8 April 2019

ARTS and Siah collaborate in a pathway for XIAP degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

beta-catenin destruction complex

cell component

1 reference

8 April 2019

Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

early endosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

biological process

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

1 reference

8 April 2019

spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

1 reference

8 April 2019

axon guidance

1 reference

8 April 2019

Mammalian homologs of seven in absentia regulate DCC via the ubiquitin–proteasome pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

anatomical structure morphogenesis

1 reference

8 April 2019

Characterization of Human Homologs of theDrosophila seven in absentia(sina) Gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

positive regulation of intrinsic apoptotic signaling pathway

IMP

1 reference

8 April 2019

ARTS and Siah collaborate in a pathway for XIAP degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

protein catabolic process

IMP

1 reference

8 April 2019

Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

positive regulation of apoptotic process

1 reference

8 April 2019

ARTS and Siah collaborate in a pathway for XIAP degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

nervous system development

1 reference

8 April 2019

Mammalian homologs of seven in absentia regulate DCC via the ubiquitin–proteasome pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

protein ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

1 reference

8 April 2019

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

1 reference

8 April 2019

protein polyubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

1 reference

8 April 2019

proteasome-mediated ubiquitin-dependent protein catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUQ4&geneProductId=UniProtKB:Q8IUQ4

1 reference

21 June 2018

ISS

protein destabilization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

ubiquitin-dependent protein catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUQ4&geneProductId=UniProtKB:Q8IUQ4

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUQ4&geneProductId=UniProtKB:Q8IUQ4

21 June 2018

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUQ4&geneProductId=UniProtKB:Q8IUQ4

21 June 2018

Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUQ4&geneProductId=UniProtKB:Q8IUQ4

negative regulation of netrin-activated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

1 reference

8 April 2019

ubiquitin-dependent protein catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUQ4

Seven-in-absentia protein, TRAF-like domain

IBA

has part(s)

1 reference

Zinc finger, SIAH-type

1 reference

Zinc finger, RING-type

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016