Ring finger protein 31 (Q21115401)

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mammalian protein found in Homo sapiens
  • E3 ubiquitin-protein ligase RNF31
  • HOIL-1-interacting protein
  • HOIP
  • RNF31
  • zinc in-between-RING-finger ubiquitin-associated domain protein
  • RING-type E3 ubiquitin transferase RNF31
  • RING finger protein 31
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Language Label Description Also known as
English
Ring finger protein 31
mammalian protein found in Homo sapiens
  • E3 ubiquitin-protein ligase RNF31
  • HOIL-1-interacting protein
  • HOIP
  • RNF31
  • zinc in-between-RING-finger ubiquitin-associated domain protein
  • RING-type E3 ubiquitin transferase RNF31
  • RING finger protein 31

Statements

molecular function
protein binding
determination method or standard
IPI
23 references
retrieved
17 October 2017
stated in
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
GOA
curator
UniProt
UniProt protein ID
Q96EP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
GOA
curator
UniProt
UniProt protein ID
Q96EP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
Molecular Basis and Regulation of OTULIN-LUBAC Interaction
GOA
curator
UniProt
UniProt protein ID
Q96EP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling
GOA
curator
UniProt
UniProt protein ID
Q96EP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
GOA
curator
UniProt
UniProt protein ID
Q96EP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis
GOA
curator
UniProt
UniProt protein ID
Q96EP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
GOA
curator
UniProt
UniProt protein ID
Q96EP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
GOA
curator
UniProt
UniProt protein ID
Q96EP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
Linear ubiquitination prevents inflammation and regulates immune signalling
GOA
curator
UniProt
UniProt protein ID
Q96EP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
A ubiquitin ligase complex assembles linear polyubiquitin chains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
retrieved
17 October 2017
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IPI
cell component
LUBAC complex
determination method or standard
IDA
IEA
7 references
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IEA
retrieved
17 October 2017
stated in
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
GOA
curator
UniProt
UniProt protein ID
Q96EP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IDA
retrieved
17 October 2017
stated in
A ubiquitin ligase complex assembles linear polyubiquitin chains
GOA
curator
UniProt
UniProt protein ID
Q96EP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IDA
retrieved
17 October 2017
stated in
Molecular Basis and Regulation of OTULIN-LUBAC Interaction
GOA
curator
UniProt
UniProt protein ID
Q96EP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IDA
retrieved
17 October 2017
stated in
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
GOA
curator
UniProt
UniProt protein ID
Q96EP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IDA
retrieved
17 October 2017
stated in
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
GOA
curator
UniProt
UniProt protein ID
Q96EP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IDA
retrieved
17 October 2017
stated in
Linear ubiquitination prevents inflammation and regulates immune signalling
GOA
curator
UniProt
UniProt protein ID
Q96EP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0
determination method or standard
IDA
biological process

Identifiers

Ensembl protein ID
PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21115401&oldid=2022961977"