Major histocompatibility complex, class II, DR beta 1 (Q21114959)

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mammalian protein found in Homo sapiens

MHC class II HLA-DR beta 1 chain
DR7
Clone P2-beta-3
HLA class II histocompatibility antigen, DRB1-7 beta chain
DW2.2/DR2.2
human leucocyte antigen DRB1
lymphocyte antigen DRB1
HLA class II histocompatibility antigen, DR-1 beta chain
major histocompatibility complex, class II, DR beta 1 precursor
MHC class II antigen DRB1*3
MHC class II antigen DRB1*7
DR-7
MHC class II antigen DRB1*15
HLA-DRB1
major histocompatibility complex, class II, DR beta 1

Language	Label	Description	Also known as
English	Major histocompatibility complex, class II, DR beta 1	mammalian protein found in Homo sapiens	MHC class II HLA-DR beta 1 chain DR7 Clone P2-beta-3 HLA class II histocompatibility antigen, DRB1-7 beta chain DW2.2/DR2.2 human leucocyte antigen DRB1 lymphocyte antigen DRB1 HLA class II histocompatibility antigen, DR-1 beta chain major histocompatibility complex, class II, DR beta 1 precursor MHC class II antigen DRB13 MHC class II antigen DRB17 DR-7 MHC class II antigen DRB1*15 HLA-DRB1 major histocompatibility complex, class II, DR beta 1

Statements

1 reference

13 November 2019

UniProt protein ID

Immunoglobulin-like fold

3 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01912

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13761

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01911

Immunoglobulin-like domain superfamily

3 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01912

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13761

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01911

MHC classes I/II-like antigen recognition protein

3 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01912

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13761

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01911

MHC class II, alpha/beta chain, N-terminal

3 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01912

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13761

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01911

MHC class II, beta chain, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin C1-set, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin/major histocompatibility complex, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

22 April 2020

UniProt protein ID

1 reference

22 April 2020

UniProt protein ID

molecular function

peptide antigen binding

determination method or standard

5 references

9 May 2019

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01912

determination method or standard

9 May 2019

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01912

determination method or standard

9 May 2019

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01912

determination method or standard

9 May 2019

Tracking antigen-specific T-cells during clinical tolerance induction in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

9 May 2019

MHCII glycosylation modulates Bacteroides fragilis carbohydrate antigen presentation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01911

determination method or standard

MHC class II receptor activity

determination method or standard

1 reference

9 May 2019

Molecular, serological and genetic studies on two new HLA-DRB1 alleles--HLA-DRB1*0704 and HLA-DRB1*1507

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

protein binding

determination method or standard

1 reference

9 May 2019

HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

MHC class II protein complex binding

determination method or standard

1 reference

26 September 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01911&geneProductId=UniProtKB:P01911

determination method or standard

MHC class II protein complex binding

determination method or standard

1 reference

9 May 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01911

determination method or standard

integral component of membrane

determination method or standard

determination method or standard

Golgi apparatus

determination method or standard

endoplasmic reticulum membrane

determination method or standard

late endosome membrane

determination method or standard

6 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01912

determination method or standard

9 May 2019

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01912

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

9 May 2019

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01911

determination method or standard

9 May 2019

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01911

determination method or standard

plasma membrane

determination method or standard

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01912

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01912

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01911

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01911

determination method or standard

MHC class II protein complex

determination method or standard

8 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01912

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01912

determination method or standard

9 May 2019

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01912

determination method or standard

9 May 2019

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01912

determination method or standard

9 May 2019

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01912

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01911

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01911

determination method or standard

9 May 2019

MHCII glycosylation modulates Bacteroides fragilis carbohydrate antigen presentation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01911

determination method or standard

lysosomal membrane

determination method or standard

9 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01912

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01912

determination method or standard

9 May 2019

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01912

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

9 May 2019

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01911

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01911

determination method or standard

9 May 2019

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01911

determination method or standard

endoplasmic reticulum

determination method or standard

determination method or standard

integral component of lumenal side of endoplasmic reticulum membrane

determination method or standard

endosome membrane

determination method or standard

determination method or standard

3 references

9 May 2019

Molecular, serological and genetic studies on two new HLA-DRB1 alleles--HLA-DRB1*0704 and HLA-DRB1*1507

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

external side of plasma membrane

determination method or standard

1 reference

9 May 2019

Tracking antigen-specific T-cells during clinical tolerance induction in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

determination method or standard

3 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01911&geneProductId=UniProtKB:P01911

determination method or standard

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01911&geneProductId=UniProtKB:P01911

determination method or standard

26 September 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01911&geneProductId=UniProtKB:P01911

determination method or standard

determination method or standard

1 reference

9 May 2019

MHCII glycosylation modulates Bacteroides fragilis carbohydrate antigen presentation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01911

determination method or standard

extracellular exosome

determination method or standard

2 references

26 September 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01911&geneProductId=UniProtKB:P01911

determination method or standard

26 September 2017

Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01911&geneProductId=UniProtKB:P01911

determination method or standard

determination method or standard

extracellular exosome

determination method or standard

biological process

antigen processing and presentation of exogenous peptide antigen via MHC class II

determination method or standard

immune system process

determination method or standard

immunoglobulin production involved in immunoglobulin-mediated immune response

determination method or standard

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

determination method or standard

humoral immune response mediated by circulating immunoglobulin

determination method or standard

peptide antigen assembly with MHC class II protein complex

determination method or standard

adaptive immune response

determination method or standard

negative regulation of interferon-gamma production

determination method or standard

1 reference

9 May 2019

HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

inflammatory response to antigenic stimulus

determination method or standard

1 reference

9 May 2019

HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

protein tetramerization

determination method or standard

1 reference

9 May 2019

Tracking antigen-specific T-cells during clinical tolerance induction in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

regulation of interleukin-4 production

determination method or standard

1 reference

9 May 2019

Tracking antigen-specific T-cells during clinical tolerance induction in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

negative regulation of T cell proliferation

determination method or standard

1 reference

9 May 2019

HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

immune response

determination method or standard

5 references

9 May 2019

Influence of MHC class II genotype on outcome of infection with hepatitis C virus. The HENCORE group. Hepatitis C European Network for Cooperative Research

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

9 May 2019

HLA molecules and nasal carriage of Staphylococcus aureus isolated from dialysis and kidney transplant patients at a hospital in Southern Brazil

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

9 May 2019

The association of HLA-DQB1, -DQA1 and -DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

9 May 2019

Tracking antigen-specific T-cells during clinical tolerance induction in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

T-helper 1 type immune response

determination method or standard

1 reference

9 May 2019

HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

positive regulation of insulin secretion involved in cellular response to glucose stimulus

determination method or standard

1 reference

9 May 2019

HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13761

determination method or standard

T cell costimulation

determination method or standard

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01911&geneProductId=UniProtKB:P01911

determination method or standard

MHC class II, beta chain, N-terminal

3 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01912

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13761

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01911

immunoglobulin C1-set

3 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01912

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13761

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01911

immunoglobulin-like domain

3 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01912

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13761

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01911

Immunoglobulin/major histocompatibility complex, conserved site

3 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01912

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13761

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01911

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

22 April 2020

UniProt protein ID

Ensembl protein ID

ENSP00000353099

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353099

ENSP00000392880

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000392880

ENSP00000412168

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000412168

ENSP00000382378

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000382378

ENSP00000405960

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000405960

ENSP00000392280

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000392280

ENSP00000409322

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000409322

ENSP00000408795

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000408795

ENSP00000403458

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000403458

ENSP00000331343

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000331343

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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