CD3d molecule (Q21114003)

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mammalian protein found in Homo sapiens

OKT3, delta chain
CD3d antigen, delta polypeptide (TiT3 complex)
CD3 antigen, delta subunit
T-cell receptor T3 delta chain
T-cell surface glycoprotein CD3 delta chain
CD3D
CD3d molecule, delta (CD3-TCR complex)
CD3 delta

Language	Label	Description	Also known as
English	CD3d molecule	mammalian protein found in Homo sapiens	OKT3, delta chain CD3d antigen, delta polypeptide (TiT3 complex) CD3 antigen, delta subunit T-cell receptor T3 delta chain T-cell surface glycoprotein CD3 delta chain CD3D CD3d molecule, delta (CD3-TCR complex) CD3 delta

Statements

1 reference

13 November 2019

UniProt protein ID

T-cell surface glycoprotein CD3 delta chain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P04234

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P04234

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P04234

CD3 gamma/delta subunit, Ig-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphorylated immunoreceptor signalling ITAM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transcription coactivator activity

determination method

1 reference

8 April 2019

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

transmembrane signaling receptor activity

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

8 April 2019

Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

determination method

2 references

determination method

1 reference

8 April 2019

Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

alpha-beta T cell receptor complex

determination method

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04234&geneProductId=UniProtKB:P04234

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

T cell receptor complex

determination method

3 references

8 April 2019

Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

8 April 2019

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

clathrin-coated vesicle membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

plasma membrane

determination method

2 references

external side of plasma membrane

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

biological process

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

regulation of immune response

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

T cell receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

T cell differentiation

determination method

1 reference

24 April 2018

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04234&geneProductId=UniProtKB:P04234

determination method

membrane organization

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

protein homooligomerization

determination method

1 reference

8 April 2019

Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

adaptive immune response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

immune system process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

cell surface receptor signaling pathway

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

8 April 2019

Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04234

determination method

positive thymic T cell selection

determination method

3 references

CD3 gamma/delta subunit, Ig-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P04234

Phosphorylated immunoreceptor signalling ITAM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P04234

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000300692

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000300692

ENSP00000376622

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000376622

ENSP00000434794

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434794

ENSP00000437335

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000437335

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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