Calcium/calmodulin dependent protein kinase II alpha (Q21113554)

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mammalian protein found in Homo sapiens

calcium/calmodulin-dependent protein kinase II alpha-B subunit
CaMK-II alpha subunit
CaMKIINalpha
caM kinase II subunit alpha
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
CaM kinase II alpha subunit
calcium/calmodulin-dependent protein kinase type II alpha chain
CAMK2A
CaM-kinase II alpha chain
calcium/calmodulin-dependent protein kinase type II subunit alpha
caMK-II subunit alpha

Language	Label	Description	Also known as
English	Calcium/calmodulin dependent protein kinase II alpha	mammalian protein found in Homo sapiens	calcium/calmodulin-dependent protein kinase II alpha-B subunit CaMK-II alpha subunit CaMKIINalpha caM kinase II subunit alpha calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha CaM kinase II alpha subunit calcium/calmodulin-dependent protein kinase type II alpha chain CAMK2A CaM-kinase II alpha chain calcium/calmodulin-dependent protein kinase type II subunit alpha caMK-II subunit alpha

Statements

1 reference

16 January 2019

UniProt protein ID

1 reference

16 January 2019

UniProt protein ID

1 reference

16 January 2019

UniProt protein ID

molecular function

transferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

protein kinase activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

protein homodimerization activity

determination method or standard

1 reference

8 April 2019

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

protein binding

determination method or standard

8 references

8 April 2019

Bcl10 is phosphorylated on Ser138 by Ca2 /calmodulin-dependent protein kinase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

Network analysis of UBE3A/E6AP-associated proteins provides connections to several distinct cellular processes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

protein serine/threonine kinase activity

determination method or standard

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

31 October 2017

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

calmodulin binding

determination method or standard

4 references

31 October 2017

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

calmodulin-dependent protein kinase activity

determination method or standard

5 references

8 April 2019

A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

identical protein binding

determination method or standard

protein serine/threonine kinase activity

determination method or standard

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

1 January 2018

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

1 January 2018

A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

calmodulin binding

determination method or standard

5 references

8 April 2019

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

protein serine/threonine kinase activity

determination method or standard

5 references

8 April 2019

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

endocytic vesicle membrane

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

presynaptic membrane

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

determination method or standard

1 reference

31 October 2017

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

determination method or standard

1 reference

31 October 2017

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

neuron projection

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

determination method or standard

1 reference

8 April 2019

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

calcium- and calmodulin-dependent protein kinase complex

determination method or standard

1 reference

8 April 2019

A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

cell projection

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

postsynaptic membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

Schaffer collateral - CA1 synapse

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

plasma membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

biological process

phosphorylation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

interferon-gamma-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

angiotensin-activated signaling pathway

determination method or standard

1 reference

8 April 2019

Activation of Na /H exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2 /calmodulin-dependent protein kinase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

positive regulation of NF-kappaB transcription factor activity

determination method or standard

1 reference

8 April 2019

Bcl10 is phosphorylated on Ser138 by Ca2 /calmodulin-dependent protein kinase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

regulation of cellular response to heat

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

dendrite morphogenesis

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

Wnt signaling pathway, calcium modulating pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

nervous system development

determination method or standard

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

peptidyl-serine phosphorylation

determination method or standard

peptidyl-threonine phosphorylation

determination method or standard

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

cell differentiation

determination method or standard

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

intracellular signal transduction

determination method or standard

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQM7&geneProductId=UniProtKB:Q9UQM7

determination method or standard

protein phosphorylation

determination method or standard

3 references

8 April 2019

A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

8 April 2019

Bcl10 is phosphorylated on Ser138 by Ca2 /calmodulin-dependent protein kinase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

dendritic spine development

determination method or standard

1 reference

8 April 2019

A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

regulation of synaptic vesicle docking

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

regulation of neuron migration

determination method or standard

1 reference

8 April 2019

De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQM7

determination method or standard

Identifiers

RefSeq protein ID

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

22 March 2019

UniProt protein ID

1 reference

16 January 2019

UniProt protein ID

Ensembl protein ID

ENSP00000261793

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000261793

ENSP00000381412

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000381412

ENSP00000426607

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000426607

ENSP00000427580

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000427580

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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