Dickkopf WNT signaling pathway inhibitor 1 (Q21112227)

The importance of Wnt signalling for neurodegeneration in Parkinson's disease

3 references

11 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

11 April 2017

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

11 April 2017

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

signal transducer activity

1 reference

11 April 2017

Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

low-density lipoprotein particle receptor binding

1 reference

8 April 2019

Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

protein binding

7 references

8 April 2019

Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

An empirical framework for binary interactome mapping

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

growth factor activity

1 reference

8 April 2019

Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

receptor antagonist activity

1 reference

11 April 2017

Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

co-receptor binding

The importance of Wnt signalling for neurodegeneration in Parkinson's disease

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

IBA

cell component

early endosome membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

1 reference

8 April 2019

plasma membrane

1 reference

8 April 2019

Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

extracellular region

extracellular space

Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

hair follicle development

IBA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

Wnt signaling pathway involved in somitogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

endoderm development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

head morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

response to retinoic acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

negative regulation of Wnt-Frizzled-LRP5/6 complex assembly

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

3 references

11 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

11 April 2017

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

11 April 2017

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

negative regulation of mesodermal cell fate specification

1 reference

8 April 2019

Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment

1 reference

8 April 2019

Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

negative regulation of Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

mesoderm formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

negative regulation of transcription by RNA polymerase II

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

1 reference

8 April 2019

negative regulation of protein binding

1 reference

8 April 2019

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

negative regulation of pathway-restricted SMAD protein phosphorylation

1 reference

8 April 2019

Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

negative regulation of BMP signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

motor learning

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

regulation of Wnt signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

embryonic limb morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

negative regulation of skeletal muscle tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

negative regulation of cardiac muscle cell differentiation

1 reference

8 April 2019

Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

negative regulation of peptidyl-serine phosphorylation

1 reference

8 April 2019

Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

regulation of receptor internalization

1 reference

8 April 2019

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

forebrain development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

cell morphogenesis involved in differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

endoderm formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

regulation of synaptic transmission, glutamatergic

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

regulation of endodermal cell fate specification

1 reference

8 April 2019

Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

regulation of synapse organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

negative regulation of canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

14 references

11 April 2017

11 April 2017

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

11 April 2017

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

NAS

11 April 2017

Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

11 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

11 April 2017

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

11 April 2017

Inhibition of the canonical Wnt pathway by Dickkopf-1 contributes to the neurodegeneration in 6-OHDA-lesioned rats

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

11 April 2017

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

11 April 2017

Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

11 April 2017

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

11 April 2017

Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

11 April 2017

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

11 April 2017

Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

11 April 2017

An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O94907

face morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

synapse pruning

1 reference

8 April 2019

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

extracellular negative regulation of signal transduction

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O94907&geneProductId=UniProtKB:O94907

regulation of dopaminergic neuron differentiation

1 reference

8 April 2019

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

positive regulation of midbrain dopaminergic neuron differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

positive regulation of gene expression

positive regulation of cell death

IGI

ISS

3 references

1 reference

8 April 2019

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

positive regulation of JUN kinase activity

1 reference

8 April 2019

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

positive regulation of Wnt signaling pathway, calcium modulating pathway

1 reference

8 April 2019

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

negative regulation of canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

16 references

8 April 2019

8 April 2019

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

NAS

8 April 2019

Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Inhibition of the canonical Wnt pathway by Dickkopf-1 contributes to the neurodegeneration in 6-OHDA-lesioned rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

positive regulation of neuron death

IBA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

1 reference

8 April 2019

negative regulation of Wnt-Frizzled-LRP5/6 complex assembly

ISS

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

8 April 2019

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

positive regulation of Wnt signaling pathway, planar cell polarity pathway

1 reference

8 April 2019

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

negative regulation of neuron projection development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

negative regulation of presynapse assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

negative regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94907

Identifiers

MeSH descriptor ID

C501126

subject named as

DKK1 protein, human

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023