Calcitonin gene-related peptide 1 (prepro) (Q21111856)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P06881

Pro-islet amyloid polypeptide

1 reference

Transporter Classification Database ID

1.C.49.1.2

hierarchical database ID heuristic

2 October 2019

based on heuristic

Calcitonin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Calcitonin peptide-like family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 September 2016

1 reference

9 August 2016

language of work or name

English

molecular function

protein-containing complex binding

protein binding

3 references

8 April 2019

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

8 April 2019

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

8 April 2019

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

signaling receptor binding

1 reference

8 April 2019

Ca2 signaling in human fetoplacental vasculature: effect of CGRP on umbilical vein smooth muscle cytosolic Ca2 concentration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

cell component

cytoplasm

1 reference

8 April 2019

Calcitonin gene-related peptide (CALCA) is a proangiogenic growth factor in the human placental development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

extracellular region

IEA

extracellular space

1 reference

8 April 2019

Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

leukocyte cell-cell adhesion

biological process

1 reference

8 April 2019

CGRP stimulates the adhesion of leukocytes to vascular endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

G protein-coupled receptor internalization

1 reference

8 April 2019

Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

positive regulation of interleukin-1 alpha production

1 reference

8 April 2019

Effects of the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide and galanin on the production of nerve growth factor and inflammatory cytokines in cultured human keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

response to yeast

1 reference

9 May 2017

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06881

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

1 reference

8 April 2019

Activation of Phospholipase C-β1 via Gαq/11during Calcium Mobilization by Calcitonin Gene-related Peptide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

Activation of Phospholipase C-β1 via Gαq/11during Calcium Mobilization by Calcitonin Gene-related Peptide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

negative regulation of osteoclast differentiation

1 reference

8 April 2019

Effects of CGRP on human osteoclast-like cell formation: a possible connection with the bone loss in neurological disorders?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

negative regulation of blood pressure

1 reference

9 May 2017

Increased blood pressure in alpha-calcitonin gene-related peptide/calcitonin gene knockout mice

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06881

cell-cell signaling

1 reference

8 April 2019

Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

antibacterial humoral response

1 reference

9 May 2017

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06881

positive regulation of macrophage differentiation

1 reference

8 April 2019

Effects of CGRP on human osteoclast-like cell formation: a possible connection with the bone loss in neurological disorders?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

receptor internalization

1 reference

8 April 2019

Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

activation of adenylate cyclase activity

regulation of blood pressure

NAS

1 reference

8 April 2019

Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

NAS

protein phosphorylation

1 reference

8 April 2019

Involvement of vascular endothelial growth factor signaling in CLR/RAMP1 and CLR/RAMP2-mediated pro-angiogenic effect of intermedin on human vascular endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

vasculature development

1 reference

8 April 2019

Calcitonin gene-related peptide (CALCA) is a proangiogenic growth factor in the human placental development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

defense response to Gram-negative bacterium

1 reference

9 May 2017

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06881

endothelial cell proliferation

1 reference

8 April 2019

Calcitonin gene-related peptide (CALCA) is a proangiogenic growth factor in the human placental development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

positive regulation of interleukin-8 production

1 reference

8 April 2019

Effects of the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide and galanin on the production of nerve growth factor and inflammatory cytokines in cultured human keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

nervous system process involved in regulation of systemic arterial blood pressure

1 reference

9 May 2017

Increased blood pressure in alpha-calcitonin gene-related peptide/calcitonin gene knockout mice

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06881

negative regulation of calcium ion transport into cytosol

1 reference

8 April 2019

Ca2 signaling in human fetoplacental vasculature: effect of CGRP on umbilical vein smooth muscle cytosolic Ca2 concentration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

innate immune response

1 reference

9 May 2017

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06881

endothelial cell migration

1 reference

8 April 2019

Calcitonin gene-related peptide (CALCA) is a proangiogenic growth factor in the human placental development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

antifungal humoral response

1 reference

9 May 2017

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06881

negative regulation of bone resorption

1 reference

8 April 2019

Effects of CGRP on human osteoclast-like cell formation: a possible connection with the bone loss in neurological disorders?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

defense response to Gram-positive bacterium

1 reference

9 May 2017

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06881

antimicrobial humoral immune response mediated by antimicrobial peptide

1 reference

9 May 2017

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06881

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

1 reference

8 April 2019

adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of signaling receptor activity

IGI

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

amylin receptor signaling pathway

IEA

IGI

1 reference

8 April 2019

Amyloid β (Aβ) Peptide Directly Activates Amylin-3 Receptor Subtype by Triggering Multiple Intracellular Signaling Pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

calcitonin gene-related peptide receptor signaling pathway

IGI

1 reference

8 April 2019

Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06881

has part(s)

Calcitonin peptide-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P06881

Calcitonin, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P06881

calcitonin gene-related peptide

0 references

Identifiers

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

1 reference

14 November 2015

http://www.uniprot.org/uniprot/P06881.txt?version=160

Transporter Classification Database ID

1.C.49.1.2

2 references

Transporter Classification database

6 September 2019

Transporter Classification database