Receptor interacting serine/threonine kinase 3 (Q21111738)

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mammalian protein found in Homo sapiens

RIP-like protein kinase 3
RIP-3
Receptor-interacting protein 3
receptor interacting protein 3
receptor-interacting serine/threonine-protein kinase 3
RIPK3

Language	Label	Description	Also known as
English	Receptor interacting serine/threonine kinase 3	mammalian protein found in Homo sapiens	RIP-like protein kinase 3 RIP-3 Receptor-interacting protein 3 receptor interacting protein 3 receptor-interacting serine/threonine-protein kinase 3 RIPK3

Statements

1 reference

13 November 2019

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y572

RHIM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

protein kinase activity

determination method or standard

7 references

8 April 2019

RIP3, a novel apoptosis-inducing kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

transcription coactivator activity

determination method or standard

1 reference

8 April 2019

Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

kinase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

protein serine/threonine kinase activity

determination method or standard

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

NF-kappaB-inducing kinase activity

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

protein binding

determination method or standard

11 references

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

identical protein binding

determination method or standard

1 reference

8 April 2019

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

protein-containing complex binding

determination method or standard

1 reference

8 April 2019

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

plasma membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y572&geneProductId=UniProtKB:Q9Y572

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

biological process

amyloid fibril formation

determination method or standard

1 reference

8 April 2019

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

protein heterooligomerization

determination method or standard

1 reference

8 April 2019

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

phosphorylation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

positive regulation of oxidoreductase activity

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

regulation of reactive oxygen species metabolic process

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

positive regulation of phosphatase activity

determination method or standard

1 reference

8 April 2019

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

positive regulation of necroptotic process

determination method or standard

3 references

8 April 2019

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

protein phosphorylation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

positive regulation of reactive oxygen species metabolic process

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

NIK/NF-kappaB signaling

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

positive regulation of NF-kappaB transcription factor activity

determination method or standard

1 reference

8 April 2019

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

apoptotic signaling pathway

determination method or standard

1 reference

8 April 2019

Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

protein autophosphorylation

determination method or standard

1 reference

8 April 2019

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

positive regulation of ligase activity

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

determination method or standard

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

I-kappaB kinase/NF-kappaB signaling

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

protein homooligomerization

determination method or standard

1 reference

8 April 2019

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

activation of protein kinase activity

determination method or standard

1 reference

8 April 2019

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

positive regulation of intrinsic apoptotic signaling pathway

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

signal transduction

determination method or standard

1 reference

8 April 2019

Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

programmed cell death

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

positive regulation of necrotic cell death

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

positive regulation of nucleic acid-templated transcription

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

determination method or standard

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000216274

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000216274

ENSP00000452328

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000452328

ENSP00000451840

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451840

ENSP00000493898

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000493898

ENSP00000495915

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495915

ENSP00000495490

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495490

PDB structure ID

1 reference

9 November 2015

http://www.uniprot.org/uniprot/Q9QZL0.txt?version=131

1 reference

9 November 2015

http://www.uniprot.org/uniprot/Q9QZL0.txt?version=131

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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