HtrA serine peptidase 2 (Q21111681)

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mammalian protein found in Homo sapiens
  • serine proteinase OMI
  • HTRA2
  • serine protease HTRA2, mitochondrial
  • epididymis secretory sperm binding protein
  • HtrA-like serine protease
  • serine protease 25
  • high temperature requirement protein A2
  • Omi stress-regulated endoprotease
  • protease, serine, 25
edit
Language Label Description Also known as
English
HtrA serine peptidase 2
mammalian protein found in Homo sapiens
  • serine proteinase OMI
  • HTRA2
  • serine protease HTRA2, mitochondrial
  • epididymis secretory sperm binding protein
  • HtrA-like serine protease
  • serine protease 25
  • high temperature requirement protein A2
  • Omi stress-regulated endoprotease
  • protease, serine, 25

Statements

molecular function
protein binding
determination method or standard
IPI
12 references
retrieved
26 September 2017
stated in
Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IPI
retrieved
26 September 2017
stated in
THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IPI
retrieved
26 September 2017
stated in
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IPI
retrieved
26 September 2017
stated in
The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IPI
retrieved
26 September 2017
stated in
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IPI
retrieved
26 September 2017
stated in
The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IPI
retrieved
26 September 2017
stated in
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IPI
retrieved
26 September 2017
stated in
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IPI
retrieved
26 September 2017
stated in
SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IPI
retrieved
26 September 2017
stated in
Dual regulatory switch confers tighter control on HtrA2 proteolytic activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IPI
retrieved
26 September 2017
stated in
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IPI
retrieved
26 September 2017
stated in
GRIM-19 associates with the serine protease HtrA2 for promoting cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IPI
serine-type endopeptidase activity
determination method or standard
TAS
IMP
IEA
5 references
retrieved
26 September 2017
stated in
Expression, purification, and functional analysis of the human serine protease HtrA2
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
TAS
retrieved
26 September 2017
stated in
Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
TAS
retrieved
26 September 2017
stated in
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IMP
retrieved
26 September 2017
stated in
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IMP
retrieved
26 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IEA
peptidase activity
determination method or standard
IDA
IEA
IMP
7 references
retrieved
26 September 2017
stated in
Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IMP
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IEA
retrieved
26 September 2017
stated in
Proteome-wide Identification of HtrA2/Omi Substrates
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IDA
retrieved
26 September 2017
stated in
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IDA
retrieved
26 September 2017
stated in
The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IDA
retrieved
26 September 2017
stated in
The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IDA
cell component
cytosol
determination method or standard
IDA
IEA
5 references
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IEA
retrieved
26 September 2017
stated in
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IDA
retrieved
26 September 2017
stated in
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IDA
retrieved
26 September 2017
stated in
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IDA
retrieved
26 September 2017
stated in
PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IDA
mitochondrion
determination method or standard
IDA
TAS
IMP
IEA
7 references
retrieved
26 September 2017
stated in
No death without life: vital functions of apoptotic effectors
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
TAS
retrieved
26 September 2017
stated in
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IMP
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IEA
retrieved
26 September 2017
stated in
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IDA
retrieved
26 September 2017
stated in
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IDA
retrieved
26 September 2017
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IDA
biological process
positive regulation of apoptotic process
determination method or standard
TAS
IMP
IEA
5 references
retrieved
26 September 2017
stated in
No death without life: vital functions of apoptotic effectors
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
TAS
retrieved
26 September 2017
stated in
Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
TAS
retrieved
26 September 2017
stated in
The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IMP
retrieved
26 September 2017
stated in
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IMP
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IEA
proteolysis
determination method or standard
IDA
IEA
IMP
TAS
8 references
retrieved
26 September 2017
stated in
Expression, purification, and functional analysis of the human serine protease HtrA2
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
TAS
retrieved
26 September 2017
stated in
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IMP
retrieved
26 September 2017
stated in
Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IMP
retrieved
26 September 2017
stated in
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IMP
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
O43464
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IEA
retrieved
26 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IEA
retrieved
26 September 2017
stated in
The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464
determination method or standard
IDA

Identifiers

MeSH descriptor ID
D000074923
subject named as
High-Temperature Requirement A Serine Peptidase 2
0 references
 
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