granulin precursor (Q21110419)

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mammalian protein found in Homo sapiens
  • PC cell-derived growth factor
  • granulin-epithelin
  • glycoprotein 88
  • epithelin
  • acrogranin
  • granulins
  • progranulin
  • GRN
  • glycoprotein of 88 Kda
  • proepithelin
  • PEPI
  • progranulins
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Language Label Description Also known as
English
granulin precursor
mammalian protein found in Homo sapiens
  • PC cell-derived growth factor
  • granulin-epithelin
  • glycoprotein 88
  • epithelin
  • acrogranin
  • granulins
  • progranulin
  • GRN
  • glycoprotein of 88 Kda
  • proepithelin
  • PEPI
  • progranulins

Statements

molecular function
protein binding
determination method or standard
IPI
15 references
retrieved
8 April 2019
stated in
Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.
GOA
curator
UniProt
UniProt protein ID
P28799
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IPI
retrieved
8 April 2019
stated in
Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations
GOA
curator
UniProt
UniProt protein ID
P28799
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IPI
retrieved
8 April 2019
stated in
Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin
GOA
curator
UniProt
UniProt protein ID
P28799
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IPI
retrieved
8 April 2019
stated in
Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease
GOA
curator
UniProt
UniProt protein ID
P28799
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IPI
retrieved
8 April 2019
stated in
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo
GOA
curator
UniProt
UniProt protein ID
P28799
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IPI
retrieved
8 April 2019
stated in
Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair
GOA
curator
UniProt
UniProt protein ID
P28799
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IPI
retrieved
8 April 2019
stated in
Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IPI
retrieved
8 April 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein interactions of the transcription factor Hoxa1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel role for drebrin in regulating progranulin bioactivity in bladder cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IPI
retrieved
8 April 2019
stated in
Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IPI
retrieved
8 April 2019
stated in
Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IPI
cell component
lysosome
determination method or standard
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P28799
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IEA
retrieved
8 April 2019
stated in
The lysosomal protein cathepsin L is a progranulin protease
GOA
curator
UniProt
UniProt protein ID
P28799
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IDA
retrieved
8 April 2019
stated in
Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes
GOA
curator
UniProt
UniProt protein ID
P28799
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IDA
retrieved
8 April 2019
stated in
Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin
GOA
curator
UniProt
UniProt protein ID
P28799
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IDA
retrieved
8 April 2019
stated in
Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations
GOA
curator
UniProt
UniProt protein ID
P28799
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IDA
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799
determination method or standard
IDA
biological process

Identifiers

MeSH descriptor ID
D000077153
subject named as
Progranulins
0 references
MeSH tree code
D06.472.699.682
0 references
D12.644.276.917
0 references
D12.776.467.917
0 references
D12.776.811.703
0 references
D23.529.917
0 references
 
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