Replication protein A1 (Q21109589)

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mammalian protein found in Homo sapiens
  • RPA1
  • MSTP075
  • replication protein A1, 70kDa
  • single-stranded DNA-binding protein
  • replication factor A protein 1
  • replication protein A 70 kDa DNA-binding subunit
  • RF-A protein 1
  • RP-A p70
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Language Label Description Also known as
English
Replication protein A1
mammalian protein found in Homo sapiens
  • RPA1
  • MSTP075
  • replication protein A1, 70kDa
  • single-stranded DNA-binding protein
  • replication factor A protein 1
  • replication protein A 70 kDa DNA-binding subunit
  • RF-A protein 1
  • RP-A p70

Statements

molecular function
protein binding
determination method or standard
IPI
21 references
retrieved
8 April 2019
stated in
Activation of the ATR kinase by the RPA-binding protein ETAA1
GOA
curator
UniProt
UniProt protein ID
P27694
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity
GOA
curator
UniProt
UniProt protein ID
P27694
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
RPA involvement in the damage-recognition and incision steps of nucleotide excision repair
GOA
curator
UniProt
UniProt protein ID
P27694
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
SLFN11 Blocks Stressed Replication Forks Independently of ATR.
GOA
curator
UniProt
UniProt protein ID
P27694
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen
GOA
curator
UniProt
UniProt protein ID
P27694
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
ETAA1 acts at stalled replication forks to maintain genome integrity
GOA
curator
UniProt
UniProt protein ID
P27694
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells
GOA
curator
UniProt
UniProt protein ID
P27694
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional and physical interaction between WRN helicase and human replication protein A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
Timed interactions between viral and cellular replication factors during the initiation of SV40 in vitro DNA replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
The role of human single-stranded DNA binding protein and its individual subunits in simian virus 40 DNA replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
Different activities of the largest subunit of replication protein A cooperate during SV40 DNA replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 modulates RPA-dependent and RPA-independent WRN helicase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
cell component
DNA replication factor A complex
determination method or standard
IDA
IEA
IPI
5 references
retrieved
17 October 2017
stated in
Sumoylation of the novel protein hRIP{beta} is involved in replication protein A deposition in PML nuclear bodies
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27694&geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27694&geneProductId=UniProtKB:P27694
determination method or standard
IEA
retrieved
17 October 2017
stated in
ETAA1 acts at stalled replication forks to maintain genome integrity
GOA
curator
UniProt
UniProt protein ID
P27694
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27694&geneProductId=UniProtKB:P27694
determination method or standard
IDA
retrieved
17 October 2017
stated in
Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA
GOA
curator
UniProt
UniProt protein ID
P27694
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27694&geneProductId=UniProtKB:P27694
determination method or standard
IDA
retrieved
17 October 2017
stated in
Activation of the ATR kinase by the RPA-binding protein ETAA1
GOA
curator
UniProt
UniProt protein ID
P27694
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27694&geneProductId=UniProtKB:P27694
determination method or standard
IDA
DNA replication factor A complex
determination method or standard
IBA
IDA
IEA
IPI
6 references
retrieved
8 April 2019
stated in
Sumoylation of the novel protein hRIP{beta} is involved in replication protein A deposition in PML nuclear bodies
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IEA
retrieved
8 April 2019
stated in
Activation of the ATR kinase by the RPA-binding protein ETAA1
GOA
curator
UniProt
UniProt protein ID
P27694
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IDA
retrieved
8 April 2019
stated in
ETAA1 acts at stalled replication forks to maintain genome integrity
GOA
curator
UniProt
UniProt protein ID
P27694
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IDA
retrieved
8 April 2019
stated in
Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA
GOA
curator
UniProt
UniProt protein ID
P27694
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IBA
biological process
telomere maintenance
determination method or standard
IBA
IC
IMP
5 references
retrieved
8 April 2019
stated in
Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres
GOA
curator
UniProt
UniProt protein ID
P27694
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IMP
retrieved
8 April 2019
stated in
RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IC
retrieved
8 April 2019
stated in
Binding polarity of RPA to telomeric sequences and influence of G-quadruplex stability
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IC
retrieved
8 April 2019
stated in
Human replication protein A unfolds telomeric G-quadruplexes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IC
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
determination method or standard
IBA

Identifiers

PDB structure ID
 
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