Protein kinase C iota (Q21109253)

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mammalian protein found in Homo sapiens
  • atypical protein kinase C-lambda/iota
  • aPKC-lambda/iota
  • PRKC-lambda/iota
  • PRKCI
  • protein kinase C iota type
  • nPKC-iota
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Language Label Description Also known as
English
Protein kinase C iota
mammalian protein found in Homo sapiens
  • atypical protein kinase C-lambda/iota
  • aPKC-lambda/iota
  • PRKC-lambda/iota
  • PRKCI
  • protein kinase C iota type
  • nPKC-iota

Statements

molecular function
protein binding
determination method or standard
IPI
24 references
retrieved
1 January 2018
stated in
Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C
GOA
curator
UniProt
UniProt protein ID
P41743
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway
GOA
curator
UniProt
UniProt protein ID
P41743
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda
GOA
curator
UniProt
UniProt protein ID
P41743
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta
GOA
curator
UniProt
UniProt protein ID
P41743
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity
GOA
curator
UniProt
UniProt protein ID
P41743
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
GOA
curator
UniProt
UniProt protein ID
P41743
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation
GOA
curator
UniProt
UniProt protein ID
P41743
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
retrieved
1 January 2018
stated in
Evolutionary and molecular facts link the WWC protein family to Hippo signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IPI
protein serine/threonine kinase activity
determination method or standard
IBA
IDA
IEA
TAS
6 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P41743
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IEA
retrieved
1 January 2018
stated in
Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IDA
retrieved
1 January 2018
stated in
Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells
GOA
curator
UniProt
UniProt protein ID
P41743
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743
determination method or standard
IBA
cell component
biological process

Identifiers

 
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