Carbamoyl-phosphate synthase 1 (Q21109242)

ATP-grasp fold, subdomain 1

1 reference

Class I glutamine amidotransferase-like

1 reference

Methylglyoxal synthase-like domain superfamily

1 reference

Pre-ATP-grasp domain superfamily

1 reference

Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily

1 reference

Carbamoyl-phosphate synthase, small subunit

1 reference

Carbamoyl-phosphate synthase, large subunit

1 reference

Methylglyoxal synthase-like domain, protein family

1 reference

ATP-grasp fold, protein family

1 reference

Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain, protein family

1 reference

Carbamoyl-phosphate synthase small subunit, N-terminal domain, protein family

1 reference

Glutamine amidotransferase-like

1 reference

Carbamoyl-phosphate synthase small subunit, GATase1 domain, protein family

1 reference

Carbamoyl-phosphate synthase large subunit, CPSase domain, protein family

1 reference

Carbamoyl-phosphate synthetase, large subunit oligomerisation domain, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

1 reference

8 April 2019

calcium ion binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

endopeptidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

1 reference

8 April 2019

ligase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

1 reference

8 April 2019

modified amino acid binding

1 reference

8 April 2019

Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

catalytic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

1 reference

8 April 2019

protein binding

3 references

8 April 2019

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

8 April 2019

Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

8 April 2019

Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

phospholipid binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

ATP binding

glutamate binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

carbamoyl-phosphate synthase (ammonia) activity

Prenatal diagnosis of carbamoyl phosphate synthetase I deficiency by identification of a missense mutation in CPS1

5 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

27 March 2018

Carbamyl phosphate synthetase I deficiency. One base substitution in an exon of the CPS I gene causes a 9-basepair deletion due to aberrant splicing

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

27 March 2018

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

27 March 2018

Human carbamylphosphate synthetase I. Stabilization, purification, and partial characterization of the enzyme from human liver

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

protein-containing complex binding

EXP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

aspartate carbamoyltransferase activity

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

carbamoyl-phosphate synthase (ammonia) activity

Carbamyl phosphate synthetase I deficiency. One base substitution in an exon of the CPS I gene causes a 9-basepair deletion due to aberrant splicing

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

8 April 2019

Prenatal diagnosis of carbamoyl phosphate synthetase I deficiency by identification of a missense mutation in CPS1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

8 April 2019

Human carbamylphosphate synthetase I. Stabilization, purification, and partial characterization of the enzyme from human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

EXP

dihydroorotase activity

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

1 reference

8 April 2019

cell component

cytoplasm

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

mitochondrial matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

1 reference

8 April 2019

mitochondrial inner membrane

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

mitochondrial nucleoid

1 reference

8 April 2019

The layered structure of human mitochondrial DNA nucleoids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

1 reference

8 April 2019

protein-containing complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

biological process

response to amino acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

response to glucagon

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

anion homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

response to steroid hormone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

cellular response to glucagon stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

hepatocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

response to zinc ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

nitrogen compound metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

1 reference

10 September 2018

response to glucocorticoid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

cellular response to fibroblast growth factor stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

proteolysis

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

response to dexamethasone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

triglyceride catabolic process

1 reference

8 April 2019

Prenatal diagnosis of carbamoyl phosphate synthetase I deficiency by identification of a missense mutation in CPS1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

nitric oxide metabolic process

1 reference

8 April 2019

Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

glutamine metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

1 reference

8 April 2019

carbamoyl phosphate biosynthetic process

response to amine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

response to growth hormone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

response to food

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

response to starvation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

liver development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

1 reference

8 April 2019

response to cAMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

homocysteine metabolic process

1 reference

8 April 2019

Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

response to toxic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

citrulline biosynthetic process

NAS

1 reference

8 April 2019

Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

NAS

response to oleic acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

cellular response to cAMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

cellular response to oleic acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

midgut development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

'de novo' pyrimidine nucleobase biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

1 reference

8 April 2019

vasodilation

1 reference

8 April 2019

Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

urea cycle

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

5 references

10 September 2018

TAS

10 September 2018

Cloning and sequence of a cDNA encoding human carbamyl phosphate synthetase I: molecular analysis of hyperammonemia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

10 September 2018

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

arginine biosynthetic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

response to lipopolysaccharide

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

10 September 2018

Release of the mitochondrial enzyme carbamoyl phosphate synthase under septic conditions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

carbamoyl phosphate biosynthetic process

Detection of carbamyl phosphate synthetase 1 deficiency using duodenal biopsy samples

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

10 September 2018

Molecular defects in human carbamoy phosphate synthetase I: mutational spectrum, diagnostic and protein structure considerations

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31327&geneProductId=UniProtKB:P31327

urea cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

4 references

8 April 2019

TAS

8 April 2019

Cloning and sequence of a cDNA encoding human carbamyl phosphate synthetase I: molecular analysis of hyperammonemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31327

Methylglyoxal synthase-like domain

has part(s)

1 reference

Carbamoyl-phosphate synthase small subunit, N-terminal domain

1 reference

Carbamoyl-phosphate synthase small subunit, GATase1 domain

1 reference

Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain

1 reference

ATP-grasp fold

1 reference

Carbamoyl-phosphate synthase large subunit, CPSase domain

1 reference

Carbamoyl-phosphate synthetase, large subunit oligomerisation domain

1 reference

Glutamine amidotransferase domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023