Troponin I3, cardiac type (Q21108986)

http://www.ebi.ac.uk/interpro/protein/P19429

Troponin I residues 1-32

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19429

Troponin domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19429

1 reference

13 November 2019

1 reference

13 November 2019

protein kinase binding

1 reference

8 April 2019

Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

protein binding

12 references

8 April 2019

Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Polycystin-2 interacts with troponin I, an angiogenesis inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Troponin I binds polycystin-L and inhibits its calcium-induced channel activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

TNNI3K is a novel mediator of myofilament function and phosphorylates cardiac troponin I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Structure of the core domain of human cardiac troponin in the Ca(2 )-saturated form

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

troponin T binding

1 reference

8 April 2019

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

calcium-dependent protein binding

1 reference

8 April 2019

Overexpression of human cardiac troponin-I and troponin-C in Escherichia coli and their purification and characterisation. Two point mutations allow high-level expression of troponin-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

calcium channel inhibitor activity

1 reference

8 April 2019

Troponin I binds polycystin-L and inhibits its calcium-induced channel activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

protein domain specific binding

1 reference

8 April 2019

The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

troponin C binding

3 references

8 April 2019

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Overexpression of human cardiac troponin-I and troponin-C in Escherichia coli and their purification and characterisation. Two point mutations allow high-level expression of troponin-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

1 reference

8 April 2019

actin filament binding

1 reference

8 April 2019

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

cell component

troponin complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19429&geneProductId=UniProtKB:P19429

5 references

24 April 2018

24 April 2018

Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2 ) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19429&geneProductId=UniProtKB:P19429

24 April 2018

Overexpression of human cardiac troponin-I and troponin-C in Escherichia coli and their purification and characterisation. Two point mutations allow high-level expression of troponin-I

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19429&geneProductId=UniProtKB:P19429

24 April 2018

Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19429&geneProductId=UniProtKB:P19429

24 April 2018

Cardiac troponin T isoforms affect the Ca2 sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19429&geneProductId=UniProtKB:P19429

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

1 reference

8 April 2019

TAS

cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

contractile fiber

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

myofibril

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

cardiac myofibril

1 reference

8 April 2019

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

cardiac Troponin complex

1 reference

8 April 2019

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

troponin complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

6 references

8 April 2019

8 April 2019

Overexpression of human cardiac troponin-I and troponin-C in Escherichia coli and their purification and characterisation. Two point mutations allow high-level expression of troponin-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2 ) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Cardiac troponin T isoforms affect the Ca2 sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

ventricular cardiac muscle tissue morphogenesis

biological process

negative regulation of ATP-dependent activity

Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Overexpression of human cardiac troponin-I and troponin-C in Escherichia coli and their purification and characterisation. Two point mutations allow high-level expression of troponin-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

regulation of muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

muscle filament sliding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

1 reference

8 April 2019

TAS

heart contraction

1 reference

8 April 2019

Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

regulation of smooth muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

striated muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

skeletal muscle contraction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

regulation of cardiac muscle contraction by calcium ion signaling

1 reference

8 April 2019

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

muscle contraction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

cardiac muscle contraction

Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016