integrin subunit alpha 6 (Q21107772)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23229

integrin alpha chain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23229

Integrin alpha, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23229

auxiliary protein involved in transmembrane transport

1 reference

Transporter Classification Database ID

8.A.54.1.2

2 October 2019

hierarchical database ID heuristic

Integrin alpha beta-propellor, protein family

1 reference

Integrin alpha-2, protein family

1 reference

FG-GAP repeat, protein family

1 reference

Integrin alpha chain, C-terminal cytoplasmic region, conserved site, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

1 reference

8 April 2019

integrin binding

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23229&geneProductId=UniProtKB:P23229

protein binding

4 references

8 April 2019

alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

8 April 2019

NAG-2, a Novel Transmembrane-4 Superfamily (TM4SF) Protein That Complexes with Integrins and Other TM4SF Proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

8 April 2019

Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

8 April 2019

Interaction of nectin-like molecule 2 with integrin alpha6beta4 and inhibition of disassembly of integrin alpha6beta4 from hemidesmosomes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

laminin binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

neuregulin binding

1 reference

8 April 2019

Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

insulin-like growth factor I binding

1 reference

8 April 2019

Cross-talk between integrin α6β4 and insulin-like growth factor-1 receptor (IGF1R) through direct α6β4 binding to IGF1 and subsequent α6β4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

cadherin binding

1 reference

26 September 2017

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23229&geneProductId=UniProtKB:P23229

cadherin binding

1 reference

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

1 reference

8 April 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

1 reference

8 April 2019

focal adhesion

1 reference

26 September 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23229&geneProductId=UniProtKB:P23229

basal part of cell

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

8 April 2019

The Androgen Receptor Induces Integrin α6β1 to Promote Prostate Tumor Cell Survival via NF-κB and Bcl-xL Independently of PI3K Signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

hemidesmosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

basement membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

cell surface

5 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23229&geneProductId=UniProtKB:P23229

26 September 2017

Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23229&geneProductId=UniProtKB:P23229

26 September 2017

Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23229&geneProductId=UniProtKB:P23229

26 September 2017

Characterization of integrin engagement during defined human embryonic stem cell culture

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23229&geneProductId=UniProtKB:P23229

26 September 2017

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23229&geneProductId=UniProtKB:P23229

basal plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

basolateral plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

external side of plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

integrin alpha6-beta4 complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

filopodium

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

focal adhesion

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

cell surface

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

8 April 2019

Characterization of integrin engagement during defined human embryonic stem cell culture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

8 April 2019

Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

8 April 2019

Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

8 April 2019

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

cellular response to extracellular stimulus

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

hemidesmosome assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

1 reference

8 April 2019

renal system development

1 reference

8 April 2019

Phenotypic spectrum of epidermolysis bullosa associated with α6β4 integrin mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

nail development

1 reference

8 April 2019

Phenotypic spectrum of epidermolysis bullosa associated with α6β4 integrin mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

positive regulation of cell-cell adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

filopodium assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

negative regulation of extrinsic apoptotic signaling pathway

1 reference

8 April 2019

The Androgen Receptor Induces Integrin α6β1 to Promote Prostate Tumor Cell Survival via NF-κB and Bcl-xL Independently of PI3K Signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

extracellular matrix organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

1 reference

8 April 2019

odontogenesis of dentin-containing tooth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

cell-substrate adhesion

1 reference

8 April 2019

Characterization of integrin engagement during defined human embryonic stem cell culture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

positive regulation of GTPase activity

1 reference

8 April 2019

Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

cell adhesion mediated by integrin

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23229&geneProductId=UniProtKB:P23229

brown fat cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

positive regulation of apoptotic process

IGI

1 reference

8 April 2019

Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

cell-substrate junction assembly

IGI

1 reference

8 April 2019

A homozygous mutation in the integrin alpha6 gene in junctional epidermolysis bullosa with pyloric atresia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

integrin-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

1 reference

8 April 2019

positive regulation of phosphorylation

1 reference

8 April 2019

The Androgen Receptor Induces Integrin α6β1 to Promote Prostate Tumor Cell Survival via NF-κB and Bcl-xL Independently of PI3K Signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

cell-matrix adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

digestive tract development

1 reference

8 April 2019

Phenotypic spectrum of epidermolysis bullosa associated with α6β4 integrin mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

ectodermal cell differentiation

IEP

1 reference

8 April 2019

Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

IEP

skin development

1 reference

8 April 2019

Phenotypic spectrum of epidermolysis bullosa associated with α6β4 integrin mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

The Androgen Receptor Induces Integrin α6β1 to Promote Prostate Tumor Cell Survival via NF-κB and Bcl-xL Independently of PI3K Signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

amelogenesis

1 reference

8 April 2019

Phenotypic spectrum of epidermolysis bullosa associated with α6β4 integrin mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

cellular response to organic cyclic compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

positive regulation of cell-substrate adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

positive regulation of cell migration

1 reference

8 April 2019

Tumour-suppressive microRNA-29s inhibit cancer cell migration and invasion by targeting laminin-integrin signalling in head and neck squamous cell carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

cell-cell adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23229

D12.776.543.750.705.408.100.550

Identifiers

MeSH descriptor ID

D039503

subject named as

Integrin alpha6

0 references

MeSH tree code

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

105464187

0 references

Transporter Classification Database ID

8.A.54.1.2

2 references

Transporter Classification database

13 March 2020

Transporter Classification database