Sp3 transcription factor (Q21107297)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02447

Transcription factor Sp3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02447

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

16 January 2019

1 reference

16 January 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

1 reference

8 April 2019

protein binding

4 references

8 April 2019

Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

8 April 2019

The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

8 April 2019

Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

8 April 2019

Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

nucleic acid binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

1 reference

8 April 2019

DNA-binding transcription factor activity, RNA polymerase II-specific

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02447&geneProductId=UniProtKB:Q02447

1 reference

1 January 2018

double-stranded DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

DNA-binding transcription factor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

1 reference

8 April 2019

RNA polymerase II transcription regulatory region sequence-specific DNA binding

IDA

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

DNA-binding transcription factor activity, RNA polymerase II-specific

A census of human transcription factors: function, expression and evolution

3 references

8 April 2019

GOA

curator

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

Norwegian University of Science and Technology, Systems Biology team

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

ISA

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

cis-regulatory region sequence-specific DNA binding

Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

cell component

PML body

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

1 reference

8 April 2019

transcription repressor complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

8 April 2019

Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

IC

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

1 reference

8 April 2019

megakaryocyte differentiation

TAS

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

regulation of transcription, DNA-templated

IDA

ossification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

lung development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

embryonic placenta development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

in utero embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

monocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

protein sumoylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02447&geneProductId=UniProtKB:Q02447

1 reference

1 January 2018

transcription, DNA-templated

TAS

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02447&geneProductId=UniProtKB:Q02447

1 reference

1 January 2018

embryonic skeletal system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

positive regulation of transcription, DNA-templated

embryonic process involved in female pregnancy

NAS

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

T cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

granulocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

embryonic camera-type eye morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

trophectodermal cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

enucleate erythrocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

erythrocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

definitive hemopoiesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

liver development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

B cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

negative regulation of transcription, DNA-templated

Sp3 is a transcriptional activator of the human alpha2(I) collagen gene

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

NAS

8 April 2019

Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

positive regulation of transcription by RNA polymerase II

Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

IMP

8 April 2019

Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

natural killer cell differentiation

IGI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02447

has part(s)

Zinc finger C2H2-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02447

Identifiers

MeSH descriptor ID

D051705

subject named as

Sp3 Transcription Factor

0 references

MeSH tree code

D12.776.260.522.750.750

0 references

D12.776.930.375.750.750

0 references

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

16 January 2019

1 reference

1 reference

1 reference

1 reference

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023