Iron-sulfur cluster assembly enzyme (Q21105385)

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mammalian protein found in Homo sapiens

IscU iron-sulfur cluster scaffold homolog
nifU-like N-terminal domain-containing protein
iron-sulfur cluster assembly enzyme ISCU, mitochondrial
NifU-like protein
ISCU

Language	Label	Description	Also known as
English	Iron-sulfur cluster assembly enzyme	mammalian protein found in Homo sapiens	IscU iron-sulfur cluster scaffold homolog nifU-like N-terminal domain-containing protein iron-sulfur cluster assembly enzyme ISCU, mitochondrial NifU-like protein ISCU

Statements

1 reference

13 November 2019

UniProt protein ID

ISC system FeS cluster assembly, IscU scaffold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H1K1

NIF system FeS cluster assembly, NifU, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

molecular adaptor activity

determination method or standard

4 iron, 4 sulfur cluster binding

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

iron-sulfur cluster binding

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

ferrous iron binding

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

protein binding

determination method or standard

6 references

8 April 2019

Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

8 April 2019

Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron–sulfur cluster biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

8 April 2019

Cochaperone binding to LYR motifs confers specificity of iron sulfur cluster delivery.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

8 April 2019

Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

8 April 2019

Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

iron-sulfur transferase activity

determination method or standard

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H1K1&geneProductId=UniProtKB:Q9H1K1

determination method or standard

2 iron, 2 sulfur cluster binding

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

determination method or standard

3 references

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H1K1&geneProductId=UniProtKB:Q9H1K1

determination method or standard

16 July 2018

Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H1K1&geneProductId=UniProtKB:Q9H1K1

determination method or standard

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H1K1&geneProductId=UniProtKB:Q9H1K1

determination method or standard

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

8 April 2019

Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

8 April 2019

Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

8 April 2019

Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

biological process

protein maturation by iron-sulfur cluster transfer

determination method or standard

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H1K1&geneProductId=UniProtKB:Q9H1K1

determination method or standard

small molecule metabolic process

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

cellular iron ion homeostasis

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

positive regulation of mitochondrial electron transport, NADH to ubiquinone

determination method or standard

1 reference

8 April 2019

MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

positive regulation of aconitate hydratase activity

determination method or standard

1 reference

8 April 2019

MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

negative regulation of iron ion import across plasma membrane

determination method or standard

1 reference

8 April 2019

MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H1K1

determination method or standard

NIF system FeS cluster assembly, NifU, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H1K1

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000310623

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000310623

ENSP00000376554

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000376554

ENSP00000411108

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411108

ENSP00000437854

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000437854

ENSP00000443272

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000443272

ENSP00000445598

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000445598

ENSP00000446606

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000446606

0 references

Microsoft Academic ID

0 references

PDB structure ID

1 reference

10 November 2015

http://www.uniprot.org/uniprot/Q9D7P6.txt?version=110

Sitelinks

Wikipedia(6 entries)

arwiki ISCU
cywiki ISCU
dewiki Eisen-Schwefel-Cluster-Gerüstprotein
enwiki ISCU
ttwiki ISCU
ukwiki ISCU

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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