Erb-b2 receptor tyrosine kinase 4 (Q21104817)

Tyrosine protein kinase, EGF/ERB/XmrK receptor

1 reference

Growth factor receptor cysteine-rich domain superfamily

1 reference

Receptor L-domain superfamily

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Growth factor receptor domain 4, protein family

1 reference

Receptor L-domain, protein family

1 reference

Furin-like cysteine-rich domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

Furin-like repeat, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

protein homodimerization activity

1 reference

8 April 2019

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

epidermal growth factor receptor binding

1 reference

16 July 2018

HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

protein binding

16 references

8 April 2019

Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tryosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

Interactions of ErbB4 and Kap1 Connect the Growth Factor and DNA Damage Response Pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

A quantitative protein interaction network for the ErbB receptors using protein microarrays

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

transmembrane receptor protein tyrosine kinase activity

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

16 July 2018

16 July 2018

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

1 January 2018

1 January 2018

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

1 reference

1 January 2018

receptor tyrosine kinase

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family

5 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

7 November 2018

7 November 2018

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

transmembrane signaling receptor activity

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

epidermal growth factor receptor binding

transmembrane receptor protein tyrosine kinase activity

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

8 April 2019

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

8 April 2019

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

cell component

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

receptor complex

1 reference

16 July 2018

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

mitochondrial matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

basolateral plasma membrane

1 reference

8 April 2019

Segregation of receptor and ligand regulates activation of epithelial growth factor receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

postsynaptic membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

ISS

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

GABA-ergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

integral component of presynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

integral component of postsynaptic density membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

cytoplasm

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

integral component of plasma membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

basal plasma membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

mitochondrial fragmentation involved in apoptotic process

biological process

1 reference

8 April 2019

The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

negative regulation of neuron migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

cell fate commitment

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

positive regulation of protein phosphorylation

1 reference

8 April 2019

The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

1 reference

16 July 2018

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

transmembrane receptor protein tyrosine kinase signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

3 references

7 November 2018

7 November 2018

Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

7 November 2018

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

1 reference

16 July 2018

MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

positive regulation of phosphatidylinositol 3-kinase activity

1 reference

5 June 2018

Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

positive regulation of protein localization to cell surface

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

protein autophosphorylation

1 reference

8 April 2019

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

lactation

The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

cell population proliferation

1 reference

1 January 2018

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

cell migration

1 reference

8 April 2019

Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

signal transduction

1 reference

8 April 2019

Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

negative regulation of cell population proliferation

1 reference

8 April 2019

Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

ERBB2 signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

phosphatidylinositol phosphate biosynthetic process

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

peptidyl-tyrosine autophosphorylation

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

positive regulation of cell population proliferation

Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

16 July 2018

HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

positive regulation of apoptotic process

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

regulation of cell motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

cellular response to epidermal growth factor stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

positive regulation of protein kinase B signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

1 reference

8 April 2019

synapse assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

negative regulation of apoptotic process

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

positive regulation of cell population proliferation

negative regulation of signal transduction

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

cell differentiation

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

negative regulation of apoptotic process

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303

positive regulation of ERK1 and ERK2 cascade

transmembrane receptor protein tyrosine kinase signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

4 references

8 April 2019

8 April 2019

Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

positive regulation of cell population proliferation

HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7422

English

tyrosine-protein kinase, active site

17 August 2016

has part(s)

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

Growth factor receptor domain 4

1 reference

Receptor L-domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

Furin-like repeat

1 reference

Furin-like cysteine-rich domain

1 reference

D08.811.913.696.620.682.725.400.009.600

Identifiers

MeSH descriptor ID

D066247

subject named as

Receptor, ErbB-4

0 references

MeSH tree code

0 references

D12.776.543.750.630.009.600

0 references

D12.776.543.750.750.400.074.600

0 references

D12.776.624.664.700.791

0 references

D23.101.140.760

0 references

D12.776.476.568.400.009.600

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

8.A.23.1.17

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023