SET domain containing 7, histone lysine methyltransferase (Q21101502)

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mammalian protein found in Homo sapiens

SET7/9
lysine N-methyltransferase 7
histone-lysine N-methyltransferase SETD7
SET domain containing lysine methyltransferase 7
histone H3-K4 methyltransferase SETD7
histone H3-lysine 4-specific methyltransferase
SET domain containing 7, lysine methyltransferase
SETD7
SET domain-containing protein 7
H3-K4-HMTase SETD7

Language	Label	Description	Also known as
English	SET domain containing 7, histone lysine methyltransferase	mammalian protein found in Homo sapiens	SET7/9 lysine N-methyltransferase 7 histone-lysine N-methyltransferase SETD7 SET domain containing lysine methyltransferase 7 histone H3-K4 methyltransferase SETD7 histone H3-lysine 4-specific methyltransferase SET domain containing 7, lysine methyltransferase SETD7 SET domain-containing protein 7 H3-K4-HMTase SETD7

Statements

1 reference

13 November 2019

UniProt protein ID

Histone-lysine N-methyltransferase, SET

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8WTS6

SET domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

methyltransferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

transferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

determination method or standard

1 reference

8 April 2019

Repression of p53 activity by Smyd2-mediated methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

chromatin binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

protein binding

determination method or standard

16 references

8 April 2019

Structural basis for the methylation site specificity of SET7/9

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

Regulation of p53 activity through lysine methylation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

Repression of p53 activity by Smyd2-mediated methylation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

Structural basis for the methylation site specificity of SET7/9

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

Structure and catalytic mechanism of the human histone methyltransferase SET7/9

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

Regulation of NF-kappaB activity through lysine monomethylation of p65.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

p53 is regulated by the lysine demethylase LSD1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

histone-lysine N-methyltransferase activity

determination method or standard

6 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WTS6&geneProductId=UniProtKB:Q8WTS6

determination method or standard

10 September 2018

Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WTS6&geneProductId=UniProtKB:Q8WTS6

determination method or standard

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WTS6&geneProductId=UniProtKB:Q8WTS6

determination method or standard

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WTS6&geneProductId=UniProtKB:Q8WTS6

determination method or standard

10 September 2018

Modulation of p53 function by SET8-mediated methylation at lysine 382

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WTS6&geneProductId=UniProtKB:Q8WTS6

determination method or standard

10 September 2018

Structural basis for the methylation site specificity of SET7/9

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WTS6&geneProductId=UniProtKB:Q8WTS6

determination method or standard

histone-lysine N-methyltransferase activity

determination method or standard

5 references

8 April 2019

Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

Structural basis for the methylation site specificity of SET7/9

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

8 April 2019

Modulation of p53 function by SET8-mediated methylation at lysine 382

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

determination method or standard

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

biological process

regulation of transcription, DNA-templated

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

peptidyl-lysine monomethylation

determination method or standard

1 reference

8 April 2019

Repression of p53 activity by Smyd2-mediated methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WTS6&geneProductId=UniProtKB:Q8WTS6

determination method or standard

cellular response to DNA damage stimulus

determination method or standard

1 reference

8 April 2019

Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

peptidyl-lysine methylation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

peptidyl-lysine dimethylation

determination method or standard

1 reference

8 April 2019

Repression of p53 activity by Smyd2-mediated methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

histone lysine methylation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

response to ethanol

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

regulation of histone H3-K9 methylation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTS6

determination method or standard

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8WTS6

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8WTS6

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000274031

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000274031

ENSP00000384336

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384336

ENSP00000385913

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000385913

ENSP00000427300

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427300

ENSP00000476302

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000476302

ENSP00000476712

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000476712

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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