Secretory leukocyte peptidase inhibitor (Q21101249)

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mammalian protein found in Homo sapiens

HUSI-1
MPI
secretory leukocyte protease inhibitor (antileukoproteinase)
protease inhibitor WAP4
mucus proteinase inhibitor
SLPI
WAP four-disulfide core domain protein 4
antileukoproteinase
seminal proteinase inhibitor
BLPI
Secretory leukocyte protease inhibitor

Language	Label	Description	Also known as
English	Secretory leukocyte peptidase inhibitor	mammalian protein found in Homo sapiens	HUSI-1 MPI secretory leukocyte protease inhibitor (antileukoproteinase) protease inhibitor WAP4 mucus proteinase inhibitor SLPI WAP four-disulfide core domain protein 4 antileukoproteinase seminal proteinase inhibitor BLPI Secretory leukocyte protease inhibitor

Statements

1 reference

13 November 2019

UniProt protein ID

Elafin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P03973

Whey Acidic Protein

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method or standard

1 reference

8 April 2019

The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

protein binding

determination method or standard

3 references

8 April 2019

The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

8 April 2019

Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

serine-type endopeptidase inhibitor activity

determination method or standard

determination method or standard

1 reference

8 April 2019

Secretory leukocyte protease inhibitor binding to mRNA and DNA as a possible cause of toxicity to Escherichia coli

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

determination method or standard

1 reference

8 April 2019

Secretory leukocyte protease inhibitor binding to mRNA and DNA as a possible cause of toxicity to Escherichia coli

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

endopeptidase inhibitor activity

determination method or standard

1 reference

1 January 2018

The acid-stable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease). Complete amino acid sequence as revealed by protein and cDNA sequencing and structural homology to whey proteins and Red Sea turtle proteinase inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03973&geneProductId=UniProtKB:P03973

determination method or standard

endopeptidase inhibitor activity

determination method or standard

3 references

8 April 2019

The acid-stable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease). Complete amino acid sequence as revealed by protein and cDNA sequencing and structural homology to whey proteins and Red Sea turtle proteinase inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

8 April 2019

Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

extracellular matrix

determination method or standard

1 reference

17 October 2017

Proteomics characterization of extracellular space components in the human aorta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03973&geneProductId=UniProtKB:P03973

determination method or standard

extracellular exosome

determination method or standard

extracellular region

determination method or standard

extracellular space

determination method or standard

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

8 April 2019

Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

8 April 2019

The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

Golgi apparatus

determination method or standard

1 reference

17 October 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03973&geneProductId=UniProtKB:P03973

determination method or standard

specific granule lumen

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

extracellular exosome

determination method or standard

1 reference

8 April 2019

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

biological process

antibacterial humoral response

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

8 April 2019

The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

negative regulation of viral genome replication

determination method or standard

1 reference

8 April 2019

The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

negative regulation of peptidase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

innate immune response

determination method or standard

negative regulation of protein binding

determination method or standard

1 reference

8 April 2019

The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

defense response to bacterium

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

negative regulation of endopeptidase activity

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

immune system process

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

neutrophil degranulation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03973

determination method or standard

WAP-type 'four-disulfide core' domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P03973

Identifiers

MeSH descriptor ID

subject named as

Secretory Leukocyte Peptidase Inhibitor

0 references

D12.644.822.500

0 references

D12.776.815.500

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000342082

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000342082

PDB structure ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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