DNA fragmentation factor subunit beta (Q21101094)

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mammalian protein found in Homo sapiens

DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
caspase-activated deoxyribonuclease
caspase-activated nuclease
caspase-activated DNase
DFFB
DFF-40
CPAN
DNA fragmentation factor 40 kDa subunit
CAD

Language	Label	Description	Also known as
English	DNA fragmentation factor subunit beta	mammalian protein found in Homo sapiens	DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) caspase-activated deoxyribonuclease caspase-activated nuclease caspase-activated DNase DFFB DFF-40 CPAN DNA fragmentation factor 40 kDa subunit CAD

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method or standard

1 reference

8 April 2019

DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

nuclease activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

protein binding

determination method or standard

1 reference

8 April 2019

Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

deoxyribonuclease activity

determination method or standard

2 references

27 March 2018

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76075&geneProductId=UniProtKB:O76075

determination method or standard

27 March 2018

Fifty C-terminal amino acid residues are necessary for the chaperone activity of DFF45 but not for the inhibition of DFF40

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76075&geneProductId=UniProtKB:O76075

determination method or standard

protein domain specific binding

determination method or standard

1 reference

8 April 2019

Fifty C-terminal amino acid residues are necessary for the chaperone activity of DFF45 but not for the inhibition of DFF40

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

identical protein binding

determination method or standard

1 reference

8 April 2019

Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

disordered domain specific binding

determination method or standard

1 reference

8 April 2019

Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

deoxyribonuclease activity

determination method or standard

3 references

10 September 2018

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76075&geneProductId=UniProtKB:O76075

determination method or standard

10 September 2018

Fifty C-terminal amino acid residues are necessary for the chaperone activity of DFF45 but not for the inhibition of DFF40

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76075&geneProductId=UniProtKB:O76075

determination method or standard

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76075&geneProductId=UniProtKB:O76075

determination method or standard

deoxyribonuclease activity

determination method or standard

4 references

8 April 2019

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

8 April 2019

Fifty C-terminal amino acid residues are necessary for the chaperone activity of DFF45 but not for the inhibition of DFF40

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

8 April 2019

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

8 April 2019

Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

determination method or standard

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76075&geneProductId=UniProtKB:O76075

determination method or standard

determination method or standard

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

8 April 2019

DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

8 April 2019

Interaction of DNA fragmentation factor (DFF) with DNA reveals an unprecedented mechanism for nuclease inhibition and suggests that DFF can be activated in a DNA-bound state

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

8 April 2019

Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

biological process

apoptotic DNA fragmentation

determination method or standard

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76075&geneProductId=UniProtKB:O76075

determination method or standard

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76075&geneProductId=UniProtKB:O76075

determination method or standard

27 March 2018

Interaction of DNA fragmentation factor (DFF) with DNA reveals an unprecedented mechanism for nuclease inhibition and suggests that DFF can be activated in a DNA-bound state

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76075&geneProductId=UniProtKB:O76075

determination method or standard

27 March 2018

Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76075&geneProductId=UniProtKB:O76075

determination method or standard

apoptotic chromosome condensation

determination method or standard

1 reference

8 April 2019

DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

DNA catabolic process

determination method or standard

1 reference

8 April 2019

Fifty C-terminal amino acid residues are necessary for the chaperone activity of DFF45 but not for the inhibition of DFF40

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

protein homooligomerization

determination method or standard

1 reference

8 April 2019

Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

apoptotic DNA fragmentation

determination method or standard

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

8 April 2019

Interaction of DNA fragmentation factor (DFF) with DNA reveals an unprecedented mechanism for nuclease inhibition and suggests that DFF can be activated in a DNA-bound state

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

8 April 2019

Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76075

determination method or standard

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000343218

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000343218

ENSP00000367454

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367454

ENSP00000436775

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000436775

ENSP00000339524

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000339524

ENSP00000345906

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000345906

ENSP00000367448

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367448

ENSP00000462175

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462175

ENSP00000462770

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462770

ENSP00000463688

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463688

ENSP00000463704

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463704

ENSP00000486916

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486916

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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