Mitogen-activated protein kinase 3 (Q15328869)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q63844

mitogen-activated protein (MAP) kinase, ERK1/2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q63844

membrane protein

1 reference

inferred from GOA cell component → membrane

Protein kinase domain, protein family

1 reference

Mitogen-activated protein (MAP) kinase, conserved site, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

1 reference

14 February 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

1 reference

14 February 2019

phosphotyrosine residue binding

1 reference

14 February 2019

Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

MAP kinase activity

Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney

7 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

ISO

24 April 2018

Role of the nude gene in epithelial terminal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

24 April 2018

MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

1 reference

14 February 2019

protein binding

4 references

14 February 2019

Treatment of cells with the angiogenic inhibitor fumagillin results in increased stability of eukaryotic initiation factor 2-associated glycoprotein, p67, and reduced phosphorylation of extracellular signal-regulated kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

Vanishin is a novel ubiquitinylated death-effector domain protein that blocks ERK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

MAP kinase kinase activity

1 reference

14 February 2019

Regulation of neuronal pH by the metabotropic Zn(2 )-sensing Gq-coupled receptor, mZnR/GPR39.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

ATP binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

MAP kinase activity

Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

ISO

14 February 2019

Role of the nude gene in epithelial terminal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

1 reference

14 February 2019

cell component

late endosome

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

Golgi apparatus

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

pseudopodium

1 reference

14 February 2019

A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

focal adhesion

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

early endosome

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

mitochondrion

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

cytoskeleton

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

1 reference

14 February 2019

nucleus

The ERK signaling cascade--views from different subcellular compartments

6 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

24 April 2018

Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

24 April 2018

Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

nucleoplasm

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

24 April 2018

Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

24 April 2018

Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63844&geneProductId=UniProtKB:Q63844

cytosol

The ERK signaling cascade--views from different subcellular compartments

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

plasma membrane

The ERK signaling cascade--views from different subcellular compartments

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

nucleus

The ERK signaling cascade--views from different subcellular compartments

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

cytoplasm

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

caveolin-mediated endocytosis

biological process

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

lung morphogenesis

1 reference

14 February 2019

Crucial requirement of ERK/MAPK signaling in respiratory tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

neural crest cell development

1 reference

14 February 2019

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

phosphorylation

Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

response to exogenous dsRNA

1 reference

14 February 2019

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

thymus development

1 reference

14 February 2019

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

regulation of early endosome to late endosome transport

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

cardiac neural crest cell development involved in heart development

1 reference

14 February 2019

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

outer ear morphogenesis

1 reference

14 February 2019

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

negative regulation of apolipoprotein binding

1 reference

14 February 2019

Inhibition of ERK1/2 and activation of liver X receptor synergistically induce macrophage ABCA1 expression and cholesterol efflux

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

positive regulation of xenophagy

1 reference

14 February 2019

TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

transcription, DNA-templated

1 reference

14 February 2019

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

cellular response to DNA damage stimulus

1 reference

14 February 2019

p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

protein phosphorylation

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

Role of the nude gene in epithelial terminal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

response to lipopolysaccharide

1 reference

14 February 2019

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

thyroid gland development

1 reference

14 February 2019

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

cartilage development

1 reference

14 February 2019

Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

face development

1 reference

14 February 2019

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

response to epidermal growth factor

ISS

cellular response to mechanical stimulus

ISO

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

arachidonic acid metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

animal organ morphogenesis

1 reference

14 February 2019

Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

Bergmann glial cell differentiation

1 reference

14 February 2019

Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

1 reference

14 February 2019

sensory perception of pain

1 reference

14 February 2019

Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

regulation of Golgi inheritance

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

regulation of ossification

1 reference

14 February 2019

Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

trachea formation

1 reference

14 February 2019

Crucial requirement of ERK/MAPK signaling in respiratory tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

regulation of cytoskeleton organization

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

lipopolysaccharide-mediated signaling pathway

1 reference

14 February 2019

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

signal transduction

1 reference

14 February 2019

Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

regulation of stress-activated MAPK cascade

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

1 reference

14 February 2019

positive regulation of macrophage chemotaxis

1 reference

14 February 2019

Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

ERK1 and ERK2 cascade

positive regulation of metallopeptidase activity

1 reference

14 February 2019

Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

regulation of cellular pH

1 reference

14 February 2019

Regulation of neuronal pH by the metabotropic Zn(2 )-sensing Gq-coupled receptor, mZnR/GPR39.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

cellular response to tumor necrosis factor

1 reference

14 February 2019

MicroRNA-494, upregulated by tumor necrosis factor-α, desensitizes insulin effect in C2C12 muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

regulation of gene expression

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

intracellular signal transduction

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844

cellular response to organic substance

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63844