Nuclear receptor subfamily 4, group A, member 2 (Q15312281)

Nuclear hormone receptor-like domain superfamily

1 reference

Zinc finger, NHR/GATA-type

1 reference

Nuclear hormone receptor, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, nuclear hormone receptor-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

14 February 2019

p57(Kip2) cooperates with Nurr1 in developing dopamine cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

sequence-specific DNA binding

HZF-3, an immediate-early orphan receptor homologous to NURR1/NOT: induction upon membrane depolarization and seizures

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

21 June 2018

21 June 2018

Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

21 June 2018

Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

DNA-binding transcription factor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

1 reference

14 February 2019

DNA-binding transcription activator activity, RNA polymerase II-specific

Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors

2 references

10 September 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

10 September 2018

Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

zinc ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

1 reference

14 February 2019

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

1 reference

14 February 2019

steroid hormone receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

1 reference

14 February 2019

protein binding

7 references

14 February 2019

TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

A novel calcium-binding protein is associated with tau proteins in tauopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Identification of a novel nurr1-interacting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

glucocorticoid receptor binding

1 reference

21 June 2018

Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

protein heterodimerization activity

DNA-binding transcription activator activity, RNA polymerase II-specific

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

DNA-binding transcription activator activity, RNA polymerase II-specific

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

10 September 2018

Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

glucocorticoid receptor binding

sequence-specific DNA binding

HZF-3, an immediate-early orphan receptor homologous to NURR1/NOT: induction upon membrane depolarization and seizures

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

14 February 2019

Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

DNA-binding transcription activator activity, RNA polymerase II-specific

5 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

7 November 2018

Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

7 November 2018

Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

7 November 2018

Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

DNA-binding transcription activator activity, RNA polymerase II-specific

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

cell component

nucleus

6 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

21 June 2018

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

21 June 2018

Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

21 June 2018

Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

1 reference

14 February 2019

TAS

nucleus

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

transcription regulator complex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

cellular response to extracellular stimulus

biological process

NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

dopaminergic neuron differentiation

TAS

response to hypoxia

1 reference

14 February 2019

Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

gene expression

1 reference

14 February 2019

Differential expression of tyrosine hydroxylase in catecholaminergic neurons of neonatal wild-type and Nurr1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

habenula development

1 reference

14 February 2019

Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

dopamine biosynthetic process

2 references

14 February 2019

Reduced tyrosine hydroxylase and GTP cyclohydrolase mRNA expression, tyrosine hydroxylase activity, and associated neurochemical alterations in Nurr1-null heterozygous mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

adult locomotory behavior

1 reference

14 February 2019

Nurr1-null heterozygous mice have reduced mesolimbic and mesocortical dopamine levels and increased stress-induced locomotor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

regulation of respiratory gaseous exchange

1 reference

14 February 2019

Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

response to amphetamine

1 reference

14 February 2019

Nurr1-null heterozygous mice have reduced mesolimbic and mesocortical dopamine levels and increased stress-induced locomotor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

positive regulation of catalytic activity

1 reference

14 February 2019

Induction of stereotypy in dopamine-deficient mice requires striatal D1 receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

neuron migration

1 reference

14 February 2019

Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

post-embryonic development

1 reference

14 February 2019

Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

transcription, DNA-templated

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

regulation of dopamine metabolic process

1 reference

14 February 2019

Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

neuron maturation

1 reference

14 February 2019

Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

positive regulation of transcription, DNA-templated

1 reference

14 February 2019

Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

dopamine metabolic process

1 reference

14 February 2019

Nurr1-null heterozygous mice have reduced mesolimbic and mesocortical dopamine levels and increased stress-induced locomotor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

central nervous system neuron differentiation

1 reference

21 June 2018

Nigrostriatal innervation is preserved in Nurr1-null mice, although dopaminergic neuron precursors are arrested from terminal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

neuron differentiation

response to inorganic substance

1 reference

14 February 2019

Identification of a new brain-specific transcription factor, NURR1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

general adaptation syndrome

1 reference

14 February 2019

Nurr1-null heterozygous mice have reduced mesolimbic and mesocortical dopamine levels and increased stress-induced locomotor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

regulation of gene expression

1 reference

14 February 2019

Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

cellular response to corticotropin-releasing hormone stimulus

1 reference

21 June 2018

Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

response to insecticide

1 reference

14 February 2019

HZF-3, an immediate-early orphan receptor homologous to NURR1/NOT: induction upon membrane depolarization and seizures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

cellular response to oxidative stress

1 reference

14 February 2019

NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

central nervous system projection neuron axonogenesis

1 reference

14 February 2019

Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

fat cell differentiation

1 reference

14 February 2019

Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

steroid hormone mediated signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

intracellular receptor signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

transcription by RNA polymerase II

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06219&geneProductId=UniProtKB:Q06219

positive regulation of transcription by RNA polymerase II

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Reduced tyrosine hydroxylase and GTP cyclohydrolase mRNA expression, tyrosine hydroxylase activity, and associated neurochemical alterations in Nurr1-null heterozygous mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

IGI

14 February 2019

TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Regulation of GTP cyclohydrolase I expression by orphan receptor Nurr1 in cell culture and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

p57(Kip2) cooperates with Nurr1 in developing dopamine cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

central nervous system neuron differentiation

cellular response to corticotropin-releasing hormone stimulus

dopaminergic neuron differentiation

The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease

3 references

14 February 2019

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

TAS

14 February 2019

Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06219

Nuclear hormone receptor, ligand-binding domain

has part(s)

1 reference

nuclear hormone receptor-type zinc finger

1 reference