FURIN (Q14916427)

1 reference

1 reference

91411822

1 reference

90868588

1 reference

90883458

1 reference

91426688

1 reference

15q26.1

1 reference

8 February 2020

IPI

1 reference

9 May 2017

Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

IPI

endopeptidase activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

3 references

9 May 2017

9 May 2017

Processing of Prothyrotropin-releasing Hormone by the Family of Prohormone Convertases

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

9 May 2017

The shedding activity of ADAM17 is sequestered in lipid rafts

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

serine-type endopeptidase activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

6 references

9 May 2017

9 May 2017

The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

9 May 2017

Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

9 May 2017

9 May 2017

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

9 May 2017

The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

serine-type endopeptidase inhibitor activity

1 reference

9 May 2017

The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

peptidase activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

5 references

9 May 2017

9 May 2017

Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

9 May 2017

Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

9 May 2017

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

9 May 2017

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

serine-type peptidase activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

hydrolase activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

peptide binding

1 reference

9 May 2017

Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4( ) cell lines

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

metal ion binding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

nerve growth factor binding

1 reference

9 May 2017

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

cell component

Golgi membrane

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

3 references

9 May 2017

9 May 2017

The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

9 May 2017

Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

extracellular space

1 reference

9 May 2017

The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

endoplasmic reticulum

IGI

1 reference

9 May 2017

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

IGI

Golgi apparatus

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

Golgi lumen

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

trans-Golgi network

1 reference

9 May 2017

Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

cell surface

1 reference

9 May 2017

Cell-surface processing of pro-ADAMTS9 by furin

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

integral component of membrane

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

trans-Golgi network transport vesicle

1 reference

9 May 2017

Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

membrane raft

1 reference

9 May 2017

The shedding activity of ADAM17 is sequestered in lipid rafts

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

extracellular exosome

1 reference

9 May 2017

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

endosome

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

endosome membrane

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

transforming growth factor beta receptor signaling pathway

biological process

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

cell population proliferation

1 reference

9 May 2017

Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

regulation of signal transduction

Ensembl genome database project

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

negative regulation of endopeptidase activity

1 reference

9 May 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

protein processing

Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin

8 references

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

Ensembl genome database project

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

9 May 2017

Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

9 May 2017

Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

9 May 2017

Processing of Prothyrotropin-releasing Hormone by the Family of Prohormone Convertases

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

9 May 2017

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

9 May 2017

Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

9 May 2017

The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

peptide hormone processing

1 reference

9 May 2017

Processing of Prothyrotropin-releasing Hormone by the Family of Prohormone Convertases

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

viral life cycle

IEP

1 reference

9 May 2017

Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4( ) cell lines

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

IEP

viral protein processing

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

extracellular matrix disassembly

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

extracellular matrix organization

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

collagen catabolic process

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

zymogen activation

nerve growth factor processing

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

negative regulation of low-density lipoprotein particle receptor catabolic process

1 reference

9 May 2017

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

nerve growth factor production

1 reference

9 May 2017

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

negative regulation of nerve growth factor production

1 reference

9 May 2017

The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

negative regulation of transforming growth factor beta1 production

1 reference

9 May 2017

Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

secretion by cell

1 reference

9 May 2017

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

regulation of protein catabolic process

1 reference

9 May 2017

Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

peptide biosynthetic process

1 reference

9 May 2017

Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

positive regulation of membrane protein ectodomain proteolysis

IC

1 reference

9 May 2017

The shedding activity of ADAM17 is sequestered in lipid rafts

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

regulation of endopeptidase activity

IC

1 reference

9 May 2017

Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

cornification

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

dibasic protein processing

1 reference

9 May 2017

The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

zymogen inhibition

regulation of lipoprotein lipase activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958

1 reference

9 May 2017

https://omabrowser.org/oma/vps/P09958/

HomoloGene ID

1930

1 reference

7 March 2020

PBB GE FURIN 201945 at fs.png
732 × 530; 12 KB

0 references

2 references

1930

2 references

1930

https://omabrowser.org/oma/vps/P09958/

1 reference

1930

1 reference

1930

Caenorhabditis elegans

2 references

1930

https://omabrowser.org/oma/vps/P09958/

expressed in

right lobe of liver

1

1 reference

7 June 2024

body of pancreas

2

1 reference

7 June 2024

right lung

3

1 reference

7 June 2024

right lobe of thyroid gland

4

1 reference

7 June 2024

left lobe of thyroid gland

5

1 reference

7 June 2024

apex of heart

6

1 reference

7 June 2024

skin of leg

7

1 reference

7 June 2024

upper lobe of left lung

8

1 reference

7 June 2024

salivary gland

9

1 reference

7 June 2024

anterior pituitary

10

1 reference

7 June 2024

http://identifiers.org/ncbigene/5045

exact match

1 reference

Identifiers.org

http://www.ebi.ac.uk/miriam/main/collections/MIR:00000069

Identifiers

1 reference

7 March 2020

1 reference

7 March 2020

1 reference

7 March 2020

1 reference

7 March 2020

0 references

1 reference

Ensembl transcript ID

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

0 references

1 reference

7 March 2020

1 reference

7 March 2020

Microsoft Academic ID

0 references

0 references

1 reference

Online Mendelian Inheritance in Man

19 August 2019

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

UMLS CUI

C0919550

1 reference

based on heuristic

inferred by common HGNC mappings on source and on Wikidata

UMLS 2023