Transcription factor 4 (Q14913984)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60722

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

14 February 2019

VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

protein dimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

1 reference

14 February 2019

protein homodimerization activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

transcription corepressor activity

1 reference

14 February 2019

Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

DNA-binding transcription factor activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60722&geneProductId=UniProtKB:Q60722

DNA-binding transcription activator activity, RNA polymerase II-specific

2 references

11 October 2018

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60722&geneProductId=UniProtKB:Q60722

14 February 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

chromatin binding

1 reference

14 February 2019

A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

protein self-association

IMP

1 reference

14 February 2019

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

IMP

E-box binding

protein C-terminus binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

protein binding

9 references

14 February 2019

E protein dosage influences brain development more than family member identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

Differential cooperation between dHAND and three different E-proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

Protein-protein interaction panel using mouse full-length cDNAs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

ETO2 coordinates cellular proliferation and differentiation during erythropoiesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

identical protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

protein heterodimerization activity

1 reference

24 April 2018

E protein dosage influences brain development more than family member identity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60722&geneProductId=UniProtKB:Q60722

TFIIB-class transcription factor binding

1 reference

14 February 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

RNA polymerase II cis-regulatory region sequence-specific DNA binding

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60722&geneProductId=UniProtKB:Q60722

24 April 2018

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60722&geneProductId=UniProtKB:Q60722

24 April 2018

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60722&geneProductId=UniProtKB:Q60722

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

14 February 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

double-stranded DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

RNA polymerase II cis-regulatory region sequence-specific DNA binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

protein heterodimerization activity

transcription regulator complex

cell component

nucleus

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60722&geneProductId=UniProtKB:Q60722

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60722&geneProductId=UniProtKB:Q60722

24 April 2018

24 April 2018

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60722&geneProductId=UniProtKB:Q60722

24 April 2018

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60722&geneProductId=UniProtKB:Q60722

beta-catenin-TCF complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

beta-catenin-TCF7L2 complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

nucleus

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

14 February 2019

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

transcription regulator complex

Differential cooperation between dHAND and three different E-proteins

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

biological process

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

1 reference

14 February 2019

protein-DNA complex assembly

1 reference

14 February 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

endothelial cell activation

1 reference

14 February 2019

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

regulation of vascular endothelial growth factor signaling pathway

1 reference

14 February 2019

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

negative regulation of gene expression

1 reference

14 February 2019

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60722&geneProductId=UniProtKB:Q60722

1 reference

24 April 2018

nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

1 reference

14 February 2019

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

1 reference

14 February 2019

positive regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

positive regulation of neuron differentiation

1 reference

24 April 2018

E protein dosage influences brain development more than family member identity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60722&geneProductId=UniProtKB:Q60722

DNA-templated transcription, initiation

1 reference

14 February 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

negative regulation of angiogenesis

1 reference

14 February 2019

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

transcription initiation from RNA polymerase II promoter

1 reference

14 February 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

positive regulation of transcription by RNA polymerase II

2 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60722&geneProductId=UniProtKB:Q60722

24 April 2018

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60722&geneProductId=UniProtKB:Q60722

regulation of transcription, DNA-templated

1 reference

14 February 2019

Differential cooperation between dHAND and three different E-proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

positive regulation of neuron differentiation

positive regulation of transcription by RNA polymerase II

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60722

Myc-type, basic helix-loop-helix (bHLH) domain

has part(s)

1 reference

InterPro Release 71.0