Protein kinase C, alpha (Q14912658)

Protein kinase-like domain superfamily

1 reference

protein kinase C, alpha/beta/gamma types

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

Protein kinase, C-terminal domain, protein family

1 reference

C2 domain, protein family

1 reference

Diacylglycerol/phorbol-ester binding domain, protein family

1 reference

AGC-kinase, C-terminal domain, protein family

1 reference

Classical Protein Kinase C alpha, catalytic domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

1 reference

8 April 2019

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

1 reference

8 April 2019

protein serine/threonine kinase activity

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20444&geneProductId=UniProtKB:P20444

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20444&geneProductId=UniProtKB:P20444

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20444&geneProductId=UniProtKB:P20444

24 April 2018

24 April 2018

PKC-alpha regulates cardiac contractility and propensity toward heart failure

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20444&geneProductId=UniProtKB:P20444

enzyme binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

histone kinase activity (H3-T6 specific)

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

1 reference

8 April 2019

zinc ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

1 reference

8 April 2019

protein binding

3 references

8 April 2019

Opposing regulatory roles of phosphorylation and acetylation in DNA mispair processing by thymine DNA glycosylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

Rapid activation of CLOCK by Ca2 -dependent protein kinase C mediates resetting of the mammalian circadian clock

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

1 reference

8 April 2019

integrin binding

1 reference

8 April 2019

A novel protein kinase C alpha-dependent signal to ERK1/2 activated by alphaVbeta3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

protein kinase C activity

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

8 April 2019

Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

Regulation of mature T lymphocyte proliferation and differentiation by Par-4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

calcium-dependent protein kinase C activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

Identity in molecular structure between "differentiation enhancing factor" of murine erythroleukemia cells and the 30 kD heparin-binding protein of developing rat brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

protein serine/threonine kinase activity

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

8 April 2019

PKC-alpha regulates cardiac contractility and propensity toward heart failure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

IBA

cell component

cytoplasm

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

8 April 2019

Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

PKC signaling at fertilization in mammalian eggs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

photoreceptor outer segment

1 reference

8 April 2019

Cloning and immunocytochemical localization of a cyclic nucleotide-gated channel alpha-subunit to all cone photoreceptors in the mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

4 references

8 April 2019

8 April 2019

PKC signaling at fertilization in mammalian eggs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

mitochondrial membranes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

1 reference

8 April 2019

endoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

plasma membrane

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

8 April 2019

The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

apical part of cell

1 reference

8 April 2019

Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

axon

1 reference

8 April 2019

cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

soma

1 reference

8 April 2019

Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

dendrite

1 reference

8 April 2019

Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

alphav-beta3 integrin-PKCalpha complex

1 reference

8 April 2019

A novel protein kinase C alpha-dependent signal to ERK1/2 activated by alphaVbeta3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

mitochondrion

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

8 April 2019

PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

protein-containing complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

neuron projection

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

membrane raft

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

presynaptic cytosol

1 reference

8 April 2019

Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

intercalated disc

1 reference

8 April 2019

MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

positive regulation of protein phosphorylation

biological process

1 reference

8 April 2019

PKC-alpha regulates cardiac contractility and propensity toward heart failure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

response to interleukin-1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

intrinsic apoptotic signaling pathway

1 reference

8 April 2019

Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

protein phosphorylation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

8 April 2019

Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

8 April 2019

Identity in molecular structure between "differentiation enhancing factor" of murine erythroleukemia cells and the 30 kD heparin-binding protein of developing rat brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

negative regulation of insulin receptor signaling pathway

1 reference

8 April 2019

Knockout of PKC alpha enhances insulin signaling through PI3K

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

1 reference

8 April 2019

positive regulation of blood vessel endothelial cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

positive regulation of dense core granule biogenesis

1 reference

8 April 2019

PKCalpha regulates platelet granule secretion and thrombus formation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

negative regulation of cell population proliferation

IGI

1 reference

8 April 2019

Functional PKC in vivo analysis using deficient mouse models

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

IGI

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

1 reference

8 April 2019

peptidyl-serine autophosphorylation

1 reference

8 April 2019

Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

positive regulation of macrophage differentiation

1 reference

8 April 2019

An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

neutrophil chemotaxis

1 reference

8 April 2019

Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

negative regulation of protein phosphorylation

IGI

positive regulation of inflammatory response

1 reference

8 April 2019

Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

chondrocyte differentiation

1 reference

8 April 2019

Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

negative regulation of protein kinase activity

1 reference

8 April 2019

Knockout of PKC alpha enhances insulin signaling through PI3K

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

1 reference

8 April 2019

regulation of the force of heart contraction

1 reference

8 April 2019

PKC-alpha regulates cardiac contractility and propensity toward heart failure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

cellular calcium ion homeostasis

1 reference

8 April 2019

PKC-alpha regulates cardiac contractility and propensity toward heart failure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

negative regulation of glucose import

1 reference

8 April 2019

Knockout of PKC alpha enhances insulin signaling through PI3K

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

1 reference

8 April 2019

regulation of peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

cellular response to carbohydrate stimulus

1 reference

8 April 2019

Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

regulation of muscle contraction

1 reference

8 April 2019

PKC-alpha regulates cardiac contractility and propensity toward heart failure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

induction of positive chemotaxis

1 reference

8 April 2019

Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

desmosome assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

negative regulation of anion channel activity

1 reference

8 April 2019

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

regulation of response to osmotic stress

1 reference

8 April 2019

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

positive regulation of bone resorption

1 reference

8 April 2019

A novel protein kinase C alpha-dependent signal to ERK1/2 activated by alphaVbeta3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

response to reactive oxygen species

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

learning or memory

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

negative regulation of translation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

peptidyl-serine phosphorylation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20444&geneProductId=UniProtKB:P20444

peptidyl-threonine phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

central nervous system neuron axonogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

response to estradiol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

negative regulation of heart contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

positive regulation of exocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

protein autophosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

regulation of receptor-mediated endocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

positive regulation of smooth muscle cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

positive regulation of synapse assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444

intracellular signal transduction

IBA

presynaptic modulation of chemical synaptic transmission

3 references

diacylglycerol/phorbol-ester binding

has part(s)

1 reference

AGC-kinase, C-terminal

1 reference

serine/threonine-protein kinase, active site

1 reference

protein kinase, C-terminal

1 reference

protein kinase, ATP binding site

1 reference

C2 domain

1 reference

protein kinase C-like, phorbol ester/diacylglycerol-binding domain

1 reference

protein kinase domain

1 reference

Classical Protein Kinase C alpha, catalytic domain

1 reference

inferred by common MeSH mappings on source and on Wikidata

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

UMLS 2023