Spleen tyrosine kinase (Q14907340)

Protein kinase-like domain superfamily

1 reference

Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily

1 reference

SH2 domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

SH2 domain, protein family

1 reference

SYK/ZAP-70, N-terminal SH2 domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

1 reference

9 May 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

1 reference

9 May 2019

protein kinase activity

non-membrane spanning protein tyrosine kinase activity

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

1 reference

9 May 2019

protein binding

12 references

9 May 2019

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Nontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple stages of B cell development

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

protein tyrosine kinase activity

10 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

9 May 2019

TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

9 May 2019

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

protein kinase binding

1 reference

9 May 2019

Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

Toll-like receptor binding

1 reference

9 May 2019

CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

phosphatase binding

2 references

SH2 domain binding

1 reference

9 May 2019

TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

protein domain specific binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

ubiquitin protein ligase binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

protein tyrosine kinase activity

11 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

1 January 2018

Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

1 January 2018

1 January 2018

Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

1 January 2018

Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

1 January 2018

TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

1 January 2018

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

1 January 2018

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

1 January 2018

Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

1 January 2018

Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

interleukin-15 receptor binding

EXP

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

cell component

cytoplasm

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

B cell receptor complex

1 reference

9 May 2019

Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

1 reference

9 May 2019

extrinsic component of cytoplasmic side of plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

1 reference

5 June 2018

early phagosome

1 reference

9 May 2019

Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

1 reference

9 May 2019

phagocytic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

1 reference

9 May 2019

cytoplasmic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

1 reference

9 May 2019

protein-containing complex

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

leukocyte cell-cell adhesion

biological process

ISS

B cell receptor signaling pathway

G protein-coupled receptor signaling pathway

TAS

1 reference

9 May 2019

Syk expression and novel function in a wide variety of tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

cellular response to molecule of fungal origin

TAS

1 reference

9 May 2019

Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

intracellular signal transduction

Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

9 May 2019

Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

positive regulation of calcium-mediated signaling

1 reference

9 May 2019

Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

adaptive immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

blood vessel morphogenesis

1 reference

9 May 2019

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

1 reference

9 May 2019

positive regulation of receptor internalization

2 references

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

1 reference

9 May 2019

regulation of neutrophil degranulation

1 reference

9 May 2019

Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

positive regulation of B cell differentiation

4 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

5 June 2018

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

5 June 2018

Syk tyrosine kinase required for mouse viability and B-cell development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

beta selection

1 reference

9 May 2019

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

receptor internalization

1 reference

9 May 2019

Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

serotonin secretion by platelet

1 reference

9 May 2019

The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

neutrophil activation involved in immune response

1 reference

5 June 2018

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

leukocyte activation involved in immune response

1 reference

9 May 2019

Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

cellular response to low-density lipoprotein particle stimulus

1 reference

9 May 2019

Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

positive regulation of bone resorption

1 reference

9 May 2019

Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

lymph vessel development

1 reference

9 May 2019

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

neutrophil chemotaxis

ISS

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

4 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

macrophage activation involved in immune response

1 reference

5 June 2018

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

cell surface receptor signaling pathway

regulation of arachidonic acid secretion

1 reference

9 May 2019

The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

defense response to bacterium

1 reference

9 May 2019

Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

peptidyl-serine phosphorylation

1 reference

9 May 2019

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

1 reference

9 May 2019

serotonin secretion

1 reference

9 May 2019

Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

positive regulation of alpha-beta T cell proliferation

1 reference

5 June 2018

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

regulation of ERK1 and ERK2 cascade

1 reference

9 May 2019

Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

9 May 2019

Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

integrin-mediated signaling pathway

regulation of superoxide anion generation

1 reference

9 May 2019

Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

peptidyl-tyrosine phosphorylation

Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

positive regulation of cell adhesion mediated by integrin

1 reference

5 June 2018

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

regulation of phagocytosis

1 reference

9 May 2019

Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

regulation of platelet activation

1 reference

9 May 2019

The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

leukotriene biosynthetic process

1 reference

9 May 2019

Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

enzyme linked receptor protein signaling pathway

1 reference

9 May 2019

Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

positive regulation of gamma-delta T cell differentiation

positive regulation of type I interferon production

1 reference

9 May 2019

CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

positive regulation of alpha-beta T cell differentiation

1 reference

9 May 2019

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

regulation of platelet aggregation

1 reference

5 June 2018

The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

cell migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

1 reference

5 June 2018

collagen-activated tyrosine kinase receptor signaling pathway

1 reference

9 May 2019

TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

positive regulation of peptidyl-tyrosine autophosphorylation

1 reference

5 June 2018

TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025

protein autophosphorylation

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

regulation of immune response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

positive regulation of interleukin-4 production

1 reference

9 May 2019

Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

interleukin-3-mediated signaling pathway

1 reference

9 May 2019

Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

macrophage activation involved in immune response

neutrophil activation involved in immune response

positive regulation of cell adhesion mediated by integrin

positive regulation of mast cell degranulation

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

positive regulation of B cell differentiation

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Syk tyrosine kinase required for mouse viability and B-cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

positive regulation of alpha-beta T cell proliferation

B cell receptor signaling pathway

Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

regulation of platelet aggregation

positive regulation of cold-induced thermogenesis

1 reference

9 May 2019

SYK kinase mediates brown fat differentiation and activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

positive regulation of protein-containing complex assembly

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

tyrosine-protein kinase, active site

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

SYK/ZAP-70, N-terminal SH2 domain

1 reference