Low density lipoprotein receptor (Q14872730)

Six-bladed beta-propeller, TolB-like

1 reference

Growth factor receptor cysteine-rich domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

EGF-like calcium-binding domain, protein family

1 reference

EGF-like domain, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A, conserved site, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A repeat, protein family

1 reference

LDLR class B repeat, protein family

1 reference

EGF-like calcium-binding, conserved site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

1 reference

14 February 2019

protein binding

1 reference

14 February 2019

Normal Sorting but Defective Endocytosis of the Low Density Lipoprotein Receptor in Mice with Autosomal Recessive Hypercholesterolemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

low-density lipoprotein particle receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

very-low-density lipoprotein particle receptor activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Apolipoprotein A-V deficiency results in marked hypertriglyceridemia attributable to decreased lipolysis of triglyceride-rich lipoproteins and removal of their remnants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

low-density lipoprotein particle binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Increased response to cholesterol feeding in apolipoprotein C1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

amyloid-beta binding

1 reference

14 February 2019

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

1 reference

14 February 2019

apical part of cell

1 reference

14 February 2019

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

basolateral plasma membrane

1 reference

14 February 2019

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

low-density lipoprotein particle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

1 reference

14 February 2019

clathrin-coated pit

membrane

cell surface

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

Golgi apparatus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

PCSK9-LDLR complex

TAS

2 references

extracellular space

1 reference

11 April 2017

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P35951

lysosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

early endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

6 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

late endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

sorting endosome

1 reference

14 February 2019

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

extracellular space

HDA

1 reference

14 February 2019

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

intracellular anatomical structure

HDA

1 reference

1 January 2018

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35951&geneProductId=UniProtKB:P35951

plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

1 reference

14 February 2019

somatodendritic compartment

1 reference

14 February 2019

Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

recycling endosome membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

lipoprotein metabolic process

biological process

positive regulation of triglyceride biosynthetic process

1 reference

14 February 2019

Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

regulation of phosphatidylcholine catabolic process

1 reference

14 February 2019

Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

steroid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

1 reference

14 February 2019

lipid transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

1 reference

14 February 2019

positive regulation of inflammatory response

1 reference

14 February 2019

Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

phospholipid transport

1 reference

14 February 2019

Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

negative regulation of gene expression

1 reference

14 February 2019

Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

lipoprotein catabolic process

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

positive regulation of gene expression

cellular response to fatty acid

1 reference

14 February 2019

Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

transport

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P35951

1 reference

11 April 2017

retinoid metabolic process

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P35951

1 reference

11 April 2017

TAS

cholesterol homeostasis

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Normal Sorting but Defective Endocytosis of the Low Density Lipoprotein Receptor in Mice with Autosomal Recessive Hypercholesterolemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

MicroRNA 302a is a novel modulator of cholesterol homeostasis and atherosclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

cholesterol transport

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

endocytosis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P35951

1 reference

11 April 2017

low-density lipoprotein particle clearance

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

cholesterol import

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

receptor-mediated endocytosis

phagocytosis

1 reference

14 February 2019

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

long-term memory

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

positive regulation of triglyceride catabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

plasma lipoprotein particle clearance

1 reference

14 February 2019

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

high-density lipoprotein particle clearance

1 reference

14 February 2019

MicroRNA 302a is a novel modulator of cholesterol homeostasis and atherosclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

regulation of protein metabolic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

negative regulation of protein metabolic process

1 reference

14 February 2019

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

response to caloric restriction

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

negative regulation of astrocyte activation

1 reference

14 February 2019

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

regulation of cholesterol metabolic process

1 reference

14 February 2019

Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

amyloid-beta clearance

1 reference

14 February 2019

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

amyloid-beta clearance by cellular catabolic process

1 reference

14 February 2019

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

negative regulation of microglial cell activation

1 reference

14 February 2019

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

positive regulation of lysosomal protein catabolic process

1 reference

14 February 2019

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

negative regulation of amyloid fibril formation

1 reference

14 February 2019

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

artery morphogenesis

1 reference

14 February 2019

Interleukin-27 receptor limits atherosclerosis in Ldlr-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35951

EGF-like calcium-binding, conserved site

has part(s)

1 reference

EGF-like calcium-binding domain

1 reference

low-density lipoprotein (LDL) receptor class A repeat

1 reference

LDLR class B repeat

1 reference

EGF-like, conserved site

1 reference

EGF-type aspartate/asparagine hydroxylation site

1 reference

EGF-like domain

1 reference

Low-density lipoprotein (LDL) receptor class A, conserved site

1 reference