Parkin RBR E3 ubiquitin protein ligase (Q14864264)

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mammalian protein found in Mus musculus
  • Prkn
  • uniprot:Q9WVS6
  • parkin RBR E3 ubiquitin-protein ligase
  • Park2
  • parkin protein
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin
  • E3 ubiquitin-protein ligase parkin
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Language Label Description Also known as
English
Parkin RBR E3 ubiquitin protein ligase
mammalian protein found in Mus musculus
  • Prkn
  • uniprot:Q9WVS6
  • parkin RBR E3 ubiquitin-protein ligase
  • Park2
  • parkin protein
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin
  • E3 ubiquitin-protein ligase parkin

Statements

molecular function
protein binding
determination method or standard
IPI
9 references
retrieved
9 May 2019
stated in
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
GOA
curator
UniProt
UniProt protein ID
Q9WVS6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
IPI
retrieved
9 May 2019
stated in
A Product of the Human Gene Adjacent to parkin Is a Component of Lewy Bodies and Suppresses Pael Receptor-induced Cell Death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
IPI
retrieved
9 May 2019
stated in
SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
IPI
retrieved
9 May 2019
stated in
Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
IPI
retrieved
9 May 2019
stated in
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
IPI
retrieved
9 May 2019
stated in
14-3-3eta is a novel regulator of parkin ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin ubiquitinates and promotes the degradation of RanBP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
IPI
cell component
mitochondrion
determination method or standard
IBA
IDA
IEA
ISO
ISS
7 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9WVS6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
ISS
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9WVS6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
IEA
retrieved
9 May 2019
stated in
Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6
determination method or standard
IBA
biological process

Identifiers

 
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