Fruquintinib inhibits VEGF/VEGFR2 axis of choroidal endothelial cells and M1-type macrophages to protect against mouse laser-induced choroidal neovascularization (Q103028025)

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scientific article published on 27 November 2020

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English	Fruquintinib inhibits VEGF/VEGFR2 axis of choroidal endothelial cells and M1-type macrophages to protect against mouse laser-induced choroidal neovascularization	scientific article published on 27 November 2020

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1 December 2020

Fruquintinib inhibits VEGF/VEGFR2 axis of choroidal endothelial cells and M1-type macrophages to protect against mouse laser-induced choroidal neovascularization (English)

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1 December 2020

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1 December 2020

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1 December 2020

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Xiaojuan Liu

1

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1 December 2020

Aisong Guo

2

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1 December 2020

Yuanyuan Tu

3

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1 December 2020

Wendie Li

4

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1 December 2020

Lele Li

5

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1 December 2020

Yuanyuan Ju

7

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1 December 2020

Yamei Zhou

8

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1 December 2020

Aimin Sang

9

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1 December 2020

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27 November 2020

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1 December 2020

Cell Death and Disease

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1 December 2020

11

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1 December 2020

11

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1 December 2020

1016

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1 December 2020

Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis.

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Angiogenesis-related factors derived from retinal glial (Müller) cells in hypoxia

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7 January 2021

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Animal models of ocular angiogenesis: from development to pathologies

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Ferrochelatase is a therapeutic target for ocular neovascularization.

1 reference

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7 January 2021

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Inhibition of experimental choroidal neovascularization in mice by anti-VEGFA/VEGFR2 or non-specific siRNA.

1 reference

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7 January 2021

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SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization

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VEGF/VEGFR2 blockade does not cause retinal atrophy in AMD-relevant models.

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Macrophages in neovascular age-related macular degeneration: friends or foes?

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Inhibition of laser-induced choroidal neovascularization by atorvastatin by downregulation of monocyte chemotactic protein-1 synthesis in mice

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Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice.

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Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer: The FRESCO Randomized Clinical Trial.

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Fruquintinib: First Global Approval

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Visible-Light Optical Coherence Tomography Angiography for Monitoring Laser-Induced Choroidal Neovascularization in Mice

1 reference

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7 January 2021

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A phase I study to investigate the metabolism, excretion, and pharmacokinetics of [14C]fruquintinib, a novel oral selective VEGFR inhibitor, in healthy Chinese male volunteers

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7 January 2021

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Choroidal neovascular membrane secondary to subfoveal leukemic infiltrate

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Dose-dependent effect of pitavastatin on VEGF and angiogenesis in a mouse model of choroidal neovascularization

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Antiangiogenic Effects of Doxazosin on Experimental Choroidal Neovascularization in Mice

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TNFα levels and macrophages expression reflect an inflammatory potential of trigeminal ganglia in a mouse model of familial hemiplegic migraine

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Culture of Human Monocyte-Derived Macrophages

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Overexpression of CREG attenuates atherosclerotic endothelium apoptosis via VEGF/PI3K/AKT pathway

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OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting Akt-NF-κB and MAPK signaling pathways.

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Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in patients with neovascular AMD

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Fruquintinib for previously treated metastatic colorectal cancer

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Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase II Study of Fruquintinib After Two Prior Chemotherapy Regimens in Chinese Patients With Advanced Nonsquamous Non‒Small-Cell Lung Cancer.

1 reference

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7 January 2021

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The clinical application of fruquintinib on colorectal cancer

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Apatinib, an Inhibitor of Vascular Endothelial Growth Factor Receptor 2, Suppresses Pathologic Ocular Neovascularization in Mice

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Vascular Endothelial Growth Factor Receptor 2 Antibody, BC001, Attenuates Laser-Induced Choroidal Neovascularization in Rhesus Monkeys (Macaca mulatta).

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Suppression of Choroidal Neovascularization and Quantitative and Qualitative Inhibition of VEGF and CCL2 by Heparin

1 reference

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7 January 2021

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Different distributions of M1 and M2 macrophages in a mouse model of laser-induced choroidal neovascularization

1 reference

https://api.crossref.org/works/10.1038/S41419-020-03222-1

7 January 2021

based on heuristic

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The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization

1 reference

https://api.crossref.org/works/10.1038/S41419-020-03222-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice

1 reference

https://api.crossref.org/works/10.1038/S41419-020-03222-1

7 January 2021

based on heuristic

inferred from DOI database lookup

VEGF-production by CCR2-dependent macrophages contributes to laser-induced choroidal neovascularization

1 reference

https://api.crossref.org/works/10.1038/S41419-020-03222-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Resveratrol prevents the development of choroidal neovascularization by modulating AMP-activated protein kinase in macrophages and other cell types

1 reference

https://api.crossref.org/works/10.1038/S41419-020-03222-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Macrophage polarization in experimental and clinical choroidal neovascularization

1 reference

https://api.crossref.org/works/10.1038/S41419-020-03222-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Knockdown of VEGF receptor-1 (VEGFR-1) impairs macrophage infiltration, angiogenesis and growth of clear cell renal cell carcinoma (CRCC)

1 reference

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7 January 2021

based on heuristic

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Vascular endothelial growth factor activates nuclear factor-kappaB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells

1 reference

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Identifiers

10.1038/S41419-020-03222-1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33247124 AND SRC:MED&resulttype=core&format=json

1 December 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33247124 AND SRC:MED&resulttype=core&format=json

1 December 2020

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