Dipeptidyl peptidase-4 inhibitor protects against non-alcoholic steatohepatitis in mice by targeting TRAIL receptor-mediated lipoapoptosis via modulating hepatic dipeptidyl peptidase-4 expression (Q101564256)

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scientific article published on 10 November 2020

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English	Dipeptidyl peptidase-4 inhibitor protects against non-alcoholic steatohepatitis in mice by targeting TRAIL receptor-mediated lipoapoptosis via modulating hepatic dipeptidyl peptidase-4 expression	scientific article published on 10 November 2020

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scholarly article

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13 November 2020

Dipeptidyl peptidase-4 inhibitor protects against non-alcoholic steatohepatitis in mice by targeting TRAIL receptor-mediated lipoapoptosis via modulating hepatic dipeptidyl peptidase-4 expression (English)

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13 November 2020

non-alcoholic steatohepatitis

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Minyoung Lee

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13 November 2020

Eugene Shin

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13 November 2020

Jaehyun Bae

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13 November 2020

Yongin Cho

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13 November 2020

Ji-Yeon Lee

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13 November 2020

Yong-Ho Lee

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13 November 2020

Byung-Wan Lee

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13 November 2020

Eun Seok Kang

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13 November 2020

Bong-Soo Cha

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13 November 2020

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10 November 2020

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13 November 2020

Scientific Reports

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13 November 2020

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13 November 2020

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13 November 2020

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13 November 2020

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes.

1 reference

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The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology

1 reference

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Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity

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Pathologic Impact of Insulin Resistance and Sensitivity on the Severity of Liver Histopathology in Pediatric Non-Alcoholic Steatohepatitis

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Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States

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Future Pharmacotherapy for Non-alcoholic Steatohepatitis (NASH): Review of Phase 2 and 3 Trials

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Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action

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Dipeptidyl-peptidase 4 inhibition: linking metabolic control to cardiovascular protection

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Circulating Levels of Soluble Dipeptidyl Peptidase-4 Are Dissociated from Inflammation and Induced by Enzymatic DPP4 Inhibition

1 reference

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7 January 2021

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Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease

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7 January 2021

based on heuristic

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Hepatic DPP4 DNA Methylation Associates With Fatty Liver.

1 reference

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7 January 2021

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Effect of sitagliptin on hepatic histological activity and fibrosis of nonalcoholic steatohepatitis patients: a 1-year randomized control trial.

1 reference

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7 January 2021

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A long-lasting dipeptidyl peptidase-4 inhibitor, teneligliptin, as a preventive drug for the development of hepatic steatosis in high-fructose diet-fed ob/ob mice

1 reference

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TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess

1 reference

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7 January 2021

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Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis.

1 reference

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7 January 2021

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Death Receptor-Mediated Cell Death and Proinflammatory Signaling in Nonalcoholic Steatohepatitis

1 reference

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Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance

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7 January 2021

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Endoplasmic reticulum stress in liver disease

1 reference

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7 January 2021

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Cell death induced by endoplasmic reticulum stress.

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7 January 2021

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Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance.

1 reference

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7 January 2021

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The dipeptidyl peptidase-4 (DPP-4) inhibitor teneligliptin functions as antioxidant on human endothelial cells exposed to chronic hyperglycemia and metabolic high-glucose memory.

1 reference

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7 January 2021

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Glucagon-like peptide-1 receptor agonism improves metabolic, biochemical, and histopathological indices of nonalcoholic steatohepatitis in mice

1 reference

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7 January 2021

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Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

The dipeptidyl peptidase-4 (DPP-4) inhibitor teneligliptin enhances brown adipose tissue function, thereby preventing obesity in mice

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

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Beneficial Effects of Evogliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, on Adiposity with Increased Ppargc1a in White Adipose Tissue in Obese Mice

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Dipeptidyl peptidase-4: a key player in chronic liver disease

1 reference

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7 January 2021

based on heuristic

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Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice

1 reference

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7 January 2021

based on heuristic

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Mechanism of lipid-lowering action of the dipeptidyl peptidase-4 inhibitor, anagliptin, in low-density lipoprotein receptor-deficient mice

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase.

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Attenuates Hepatic Lipogenesis via AMPK Activation in Non-Alcoholic Fatty Liver Disease Model Mice

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A dipeptidyl peptidase-IV inhibitor improves hepatic steatosis and insulin resistance by AMPK-dependent and JNK-dependent inhibition of LECT2 expression.

1 reference

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based on heuristic

inferred from DOI database lookup

Is hepatic lipogenesis fundamental for NAFLD/NASH? A focus on the nuclear receptor coactivator PGC-1β.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of hepatocyte nuclear factor 1b induces hepatic steatosis through DPP4/NOX1-mediated regulation of superoxide

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Sitagliptin attenuates methionine/choline-deficient diet-induced steatohepatitis.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Vildagliptin Can Alleviate Endoplasmic Reticulum Stress in the Liver Induced by a High Fat Diet.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of hepatic fibrogenesis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic stellate cell in rats

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition.

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity.

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Mouse models of nonalcoholic steatohepatitis in preclinical drug development

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Intake of trans fatty acids causes nonalcoholic steatohepatitis and reduces adipose tissue fat content

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Treating Hepatic Steatosis and Fibrosis by Modulating Mitochondrial Pyruvate Metabolism

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Adipose dipeptidyl peptidase-4 and obesity: correlation with insulin resistance and depot-specific release from adipose tissue in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Sitagliptin promotes macrophage‐to‐faeces reverse cholesterol transport through reduced intestinal cholesterol absorption in obese insulin resistant CETP‐apoB100 transgenic mice

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

The DPP-4 inhibitor vildagliptin impacts the gut microbiota and prevents disruption of intestinal homeostasis induced by a Western diet in mice

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1038/S41598-020-75288-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Dose translation between laboratory animals and human in preclinical and clinical phases of drug development

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Long-chain fatty acid activates hepatocytes through CD36 mediated oxidative stress.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Design and validation of a histological scoring system for nonalcoholic fatty liver disease

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/S41598-020-75288-Y

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33173107 AND SRC:MED&resulttype=core&format=json

13 November 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33173107 AND SRC:MED&resulttype=core&format=json

13 November 2020

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