NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications (Q100490619)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33028807 AND SRC:MED&resulttype=core&format=json

17 October 2020

title

NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications (English)

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17 October 2020

1

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17 October 2020

Dan Xie

4

1 reference

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17 October 2020

Rui-Hua Xu

5

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17 October 2020

author name string

Jin-Fei Lin

2

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17 October 2020

Tian Tian

3

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17 October 2020

publication date

7 October 2020

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Signal Transduction and Targeted Therapy

17 October 2020

published in

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17 October 2020

volume

5

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17 October 2020

issue

1

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17 October 2020

page(s)

231

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The NAD metabolome--a key determinant of cancer cell biology

17 October 2020

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7 January 2021

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7 January 2021

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

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7 January 2021

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7 January 2021

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Oxidative stress inhibits distant metastasis by human melanoma cells

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The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer

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7 January 2021

The Role of Single-Nucleotide Polymorphisms in the Function of Candidate Tumor Suppressor ALDH1L1

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7 January 2021

Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression

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7 January 2021

The importance of mitochondrial folate enzymes in human colorectal cancer.

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7 January 2021

Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells

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7 January 2021

Effects of mitotane on gene expression in the adrenocortical cell line NCI-H295R: a microarray study.

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7 January 2021

Anti-inflammatory agent indomethacin reduces invasion and alters metabolism in a human breast cancer cell line

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7 January 2021

Characterization of cytosolic malic enzyme in human tumor cells

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7 January 2021

Escaping Death: Mitochondrial Redox Homeostasis in Cancer Cells

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7 January 2021

Malic Enzyme 1 (ME1) is pro-oncogenic in Apc mice

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7 January 2021

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

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7 January 2021

Malic enzyme 1 (ME1) is a potential oncogene in gastric cancer cells and is associated with poor survival of gastric cancer patients

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7 January 2021

Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma.

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7 January 2021

ME1 promotes basal-like breast cancer progression and associates with poor prognosis

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7 January 2021

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Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis

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7 January 2021

MicroRNA-30a attenuates mutant KRAS-driven colorectal tumorigenesis via direct suppression of ME1.

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7 January 2021

Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions

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7 January 2021

The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas

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7 January 2021

Down-regulation of malic enzyme 1 and 2: Sensitizing head and neck squamous cell carcinoma cells to therapy-induced senescence

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7 January 2021

Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2

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7 January 2021

Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling.

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7 January 2021

Human mitochondrial NAD(P)( )-dependent malic enzyme participates in cutaneous melanoma progression and invasion

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7 January 2021

Metabolic vulnerability in melanoma: a ME2 (me too) story

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7 January 2021

ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis.

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7 January 2021

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

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7 January 2021

Effects of ME3 on the proliferation, invasion and metastasis of pancreatic cancer cells through epithelial-mesenchymal transition

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7 January 2021

Redox Modulation by Reversal of the Mitochondrial Nicotinamide Nucleotide Transhydrogenase.

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7 January 2021

Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function

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7 January 2021

Physiological roles of nicotinamide nucleotide transhydrogenase

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7 January 2021

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure.

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7 January 2021

Nicotinamide nucleotide transhydrogenase-mediated redox homeostasis promotes tumor growth and metastasis in gastric cancer

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7 January 2021

Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation

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7 January 2021

Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency

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7 January 2021

Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle

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7 January 2021

Saturated Fatty Acid Activates T Cell Inflammation Through a Nicotinamide Nucleotide Transhydrogenase (NNT)-Dependent Mechanism

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7 January 2021

Enhanced expression of nicotinamide nucleotide transhydrogenase (NNT) and its role in a human T cell line continuously exposed to asbestos

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7 January 2021

Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling

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7 January 2021

Wild-Type IDH Enzymes as Actionable Targets for Cancer Therapy

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7 January 2021

Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight

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7 January 2021

Identification of isocitrate dehydrogenase 1 as a potential diagnostic and prognostic biomarker for non-small cell lung cancer by proteomic analysis.

1 reference

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7 January 2021

Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells.

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7 January 2021

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

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7 January 2021

Isocitrate dehydrogenase 1 is a novel plasma biomarker for the diagnosis of non-small cell lung cancer.

1 reference

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7 January 2021

Regulation of singlet oxygen-induced apoptosis by cytosolic NADP -dependent isocitrate dehydrogenase

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7 January 2021

Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis

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7 January 2021

Low level of isocitrate dehydrogenase 1 predicts unfavorable postoperative outcomes in patients with clear cell renal cell carcinoma

1 reference

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7 January 2021

Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer

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7 January 2021

Quantitative proteome analysis of ovarian cancer tissues using a iTRAQ approach

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7 January 2021

Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer

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7 January 2021

Isocitrate Dehydrogenase 2 Suppresses the Invasion of Hepatocellular Carcinoma Cells via Matrix Metalloproteinase 9.

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7 January 2021

Isocitrate dehydrogenase 2 inhibits gastric cancer cell invasion via matrix metalloproteinase 7.

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor Growth

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Reductive carboxylation supports growth in tumour cells with defective mitochondria.

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Wild-type and mutated IDH1/2 enzymes and therapy responses.

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect.

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Metabolic recoding of epigenetics in cancer

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Biological Role and Therapeutic Potential of IDH Mutations in Cancer.

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Glutamate production from ammonia via glutamate dehydrogenase 2 activity supports cancer cell proliferation under glutamine depletion

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Glutamate Dehydrogenase, a Complex Enzyme at a Crucial Metabolic Branch Point

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Glutamate dehydrogenase (GLUD1) expression in breast cancer

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Glutamate dehydrogenase is a novel prognostic marker and predicts metastases in colorectal cancer patients

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Glutamate dehydrogenase inhibits tumor growth in gastric cancer through the Notch signaling pathway

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass.

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Physiological Role of Glutamate Dehydrogenase in Cancer Cells

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Inhibition of GOT1 sensitizes colorectal cancer cells to 5-fluorouracil

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition.

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Fatty Acid Oxidation in Cell Fate Determination

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Cancer metabolism: fatty acid oxidation in the limelight

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

When fats commit crimes: fatty acid metabolism, cancer stemness and therapeutic resistance

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Inhibition of fatty acid catabolism augments the efficacy of oxaliplatin-based chemotherapy in gastrointestinal cancers

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

HBx regulates fatty acid oxidation to promote hepatocellular carcinoma survival during metabolic stress

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Disrupting redox stabilizer: a novel therapeutic strategy for colorectal cancer

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Enhanced degradation of dihydrofolate reductase through inhibition of NAD kinase by nicotinamide analogs

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Role of glucose-6-phosphate dehydrogenase inhibition in the antiproliferative effects of dehydroepiandrosterone on human breast cancer cells

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

The pentose phosphate pathway: an antioxidant defense and a crossroad in tumor cell fate

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Real-time monitoring of NADPH levels in living mammalian cells using fluorescence-enhancing protein bound to NADPHs

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Catechin gallates are NADP -competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP as a coenzyme

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

A new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo.

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Aspirin inhibits glucose‑6‑phosphate dehydrogenase activity in HCT 116 cells through acetylation: Identification of aspirin-acetylated sites

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Propylselen inhibits cancer cell growth by targeting glutamate dehydrogenase at the NADP binding site

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Discovery of a novel inhibitor of NAD(P)( )-dependent malic enzyme (ME2) by high-throughput screening

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

A small-molecule inhibitor suppresses the tumor-associated mitochondrial NAD(P) -dependent malic enzyme (ME2) and induces cellular senescence

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

An indispensable role of CPT-1a to survive cancer cells during energy stress through rewiring cancer metabolism

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

Systematic analyses of glutamine and glutamate metabolisms across different cancer types.

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

How cancer metabolism is tuned for proliferation and vulnerable to disruption

1 reference

https://api.crossref.org/works/10.1038/S41392-020-00326-0

7 January 2021

10.1038/S41392-020-00326-0

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33028807 AND SRC:MED&resulttype=core&format=json

17 October 2020

1 reference