Molecular glues hold significant promise for treating diseases that are currently difficult to manage, including various cancers and genetic disorders. Their unique ability to induce specific protein-protein interactions opens up new therapeutic avenues. A significant challenge for the discovery of new glue compounds is the complicated dynamics created by multi-component complexes of #proteins and #smallmolecules. The formation and stability of these complexes can be influenced by various factors, making the identification of effective molecular glues a challenging task. In the upcoming Cytiva webinar, ZoBio 's expert Pim de Vink will try to demystify glues and prove that working with them doesn’t have to be scary. He will also demonstrate that #fragments can serve as an excellent starting point for discovering #molecularglues. You can still register here: https://lnkd.in/e6jCmh67
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💡 NEW SPOTLIGHT 💡 As the demand for rapid and comprehensive genetic testing grows, a single assay capable of detecting all key mutations within a complex disease is becoming essential for timely and effective patient care. Chaxiraxi Arzola explores a newly published study by Sande CM et al (2024) investigating how high-resolution melting (HRM) emerges as an economically efficient and highly reliable diagnostic technique, facilitating multiplex testing of Philadelphia-negative myeloproliferative neoplasms (MPNs). Learn more today 👉 https://lnkd.in/ewEHrRtr
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What if you could cut and paste genes like words in a document? That’s the promise of CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats), a molecular scissor that precisely snips DNA at targeted locations. At Garvan, Professor Robert Brink, who leads Garvan’s Immune Biotherapies Program, is using CRISPR to develop new therapy approaches for rare genetic immune and blood diseases. Find out more: https://ow.ly/ARzP50SeYvO
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Rhnull phenotype is a rare blood group characterized by the lack of expression of all Rh antigens (D, C, c, E and e) on the red cells. The phenotype is further classified into the regulator and amorph type based on underlying genetic defect. The clinical significance of its recognition is that such patients suffer from Rhnull syndrome associated with osmotically fragile red cells called stomatocytes with subsequent chronic haemolytic anaemia of varying degree. Another importance is that such subjects readily form alloantibodies on exposure to Rh antigens.
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I am pleased that our joint paper on gene-modifying tofersen treatment of people with ALS caused by the most common genetic SOD1 variant, p.D91A, is now published online. The work presents data from 6 German ALS centers with very current relevance for patient counseling and therapy decisions. The approach is also conceptually new since it provides evidence for the causality of an ALS variant based on a biomarker response to a gene-specific treatment: https://lnkd.in/eSA-8ekV https://rdcu.be/dOUov
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Today, on 𝐖𝐨𝐫𝐥𝐝 𝐓𝐡𝐚𝐥𝐚𝐬𝐬𝐞𝐦𝐢𝐚 𝐃𝐚𝐲, let's acknowledge the importance of molecular testing in the diagnosis and management of this genetic disorder. As we unite to raise awareness, let's shine a light on the crucial role molecular testing plays in the lives of thalassemia patients worldwide. The Devyser Thalassemia NGS kit offers the amplification of all target sequences within a single tube, offering a time and effort-saving solution. Moreover, this test can detect additional sequence variants that could be missed while analyzing the alpha or beta regions only or employing allele-specific mutation panels. Discover further insights on this topic by exploring the blog: http://surl.li/tnhof #WorldThalassemiaDay #MolecularTesting #HealthcareInnovation #ThalassemiaAwareness #PrecisionMedicine
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🔬 Rare Disease Day 2024 will be falling on February 29 this year. Exciting strides have been made, particularly for genetic disorders that can be treated by correcting, replacing or silencing defective genes. Innovations like CRISPR-Cas9 offer new possibilities for correcting defective genes, bringing hope for conditions like Duchenne muscular dystrophy and inherited blindness. To learn more about novel rare disease treatments and advances in clinical research, read more here: https://buff.ly/42Yecia #RareDiseaseDay2024 #RareDisease #RareDiseaseClinicalTrials #RareDiseaseAwareness
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Have you ever heard of molecular diagnostics?🧬 It's a cutting-edge approach that examines our genetic material to uncover disease risk factors, detect infections, and more. From cancer to genetic disorders, molecular testing allows for highly targeted treatments based on our unique DNA. Whether through techniques like FISH or cytogenetic analysis, this precision tool reshapes how doctors diagnose and treat, offering clearer insights and personalized healthcare. Ready to unlock the secrets of your DNA? Contact Clarity Labs today to find out more about our molecular testing services. #MolecularDiagnostics #FutureOfHealthcare #ClarityLabs
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Interesting paper to read. How fast the biosensing research area is advancing.
Researchers have used artificial intelligence to develop protein biosensors that could help them investigate cancers that have mutations in RAS genes. Learn more: https://go.nih.gov/OzXMXzC
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New tools that could help to map the activities, mechanisms, and functions of physiologically relevant molecules such as Ras in cancer field. #cancer #biochemistry #chemistry #microscopy #cellsignalling #biology #AI #sensor #protein
Researchers have used artificial intelligence to develop protein biosensors that could help them investigate cancers with mutations in RAS genes. Learn more. https://go.nih.gov/BrycyC5
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Have you ever heard of molecular diagnostics?🧬 It's a cutting-edge approach that examines our genetic material to uncover disease risk factors, detect infections, and more. From cancer to genetic disorders, molecular testing allows for highly targeted treatments based on our unique DNA. Whether through techniques like FISH or cytogenetic analysis, this precision tool reshapes how doctors diagnose and treat, offering clearer insights and personalized healthcare. Ready to unlock the secrets of your DNA? Contact Clarity Labs today to find out more about our molecular testing services. #MolecularDiagnostics #FutureOfHealthcare #ClarityLabs
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