Wellcome Sanger Institute’s Post

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‘Gene misbehaviour’ — where genes are active when they should be off — is surprisingly common in healthy people. In a first-of-its-kind study, scientists from the Wellcome Sanger Institute, University of Cambridge and AstraZeneca identified mechanisms behind these gene activity errors, which could be used in future research to investigate various complex diseases. It could also inform precision medicine approaches 💊 The human genome contains about 19,900 genes, which serve as our body's instruction manual, encoding proteins for cell functions. Proper gene regulation involves turning these instructions on and off. Misexpression of typically inactive genes can disrupt normal cell function, a phenomenon previously unexplored in the general population 🧬 The team studied blood samples from 4,568 healthy individuals. While rare at the individual gene level, they found that nearly all samples exhibited some level of misexpression, involving over half of the genes that should be inactive. These events can result from rare structural changes in the DNA. 🗨 “Until now, we have been looking at disease risk through the lens of highly active genes. Our study reveals ‘unusual’ gene activity is far more usual than previously thought and we need to consider the full picture, including genes that shouldn't be active but sometimes are. This is a big step towards more personalised healthcare, enabling a more comprehensive understanding of all the ways our genes impact our health.” Thomas Vanderstichele, first author of the study at the Wellcome Sanger Institute. ⬇ Read the full story #geneexpression #precisionmedicine #genomics https://lnkd.in/eQhuwCHC

📰 In our latest Newsletter for July 2024 we cover: - Cutting-edge genomic test can improve care of children with cancer - Hacking AI for genomics - Mobile phone data helps track pathogen spread and profile of Stephen Bentley - Sanger scientists recognised by EMBO - 'Gene misbehaviour' widespread in healthy population Stay in the loop 👉 Click 📰 Read 🖥 Subscribe ⬇ #latestgeneticresearch

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