Visual Abstract’s Post

#Macrophages at the interface of the co-evolving cancer ecosystem:- •Macrophages are versatile and heterogeneous innate immune cells undertaking central functions in balancing immune responses and tissue repair to maintain #homeostasis. •This plasticity, once co-opted by #malignant outgrowth, orchestrates manifold reciprocal interactions within the tumor microenvironment, fueling the evolution of the cancer ecosystem. •Here, we review the multilayered sources of influence that jointly underpin and longitudinally shape #tumor-associated macrophage (#TAM) phenotypic states in solid neoplasms. •We discuss how, in response to these signals, #TAMs steer tumor evolution in the context of natural selection, biological dispersion, and treatment resistance. •A number of research frontiers to be tackled are laid down in this review to therapeutically exploit the complex roles of #TAMs in cancer. •Building upon knowledge obtained from currently applied TAM-targeting strategies and using next generation technologies, we propose conceptual advances and novel therapeutic avenues to rewire TAM multifaceted regulation of the co-evolving cancer ecosystem. #macrophages #cancerresearch #tam #cancers

⛳ By harnessing the capacity of the immune system to fight against cancer, #immunotherapies have shown promising results. However, there is still an urgent need for more robust ex-vivo assays to enable response prediction to immune therapies in a patient-specific setting. Using #Gri3D, we set up a robust and scalable assay to study tumor-infiltrating lymphocytes (TILs) functionality and evaluate the killing capacity of patient-derived #TILs to autologous human colorectal cancer #tumoroids. Scientist from EPFL (École polytechnique fédérale de Lausanne) used this system to allow not only the identification of immunogenic tumors, but also the testing of patients for response to immunomodulators, enabling personalized immuno-oncology. 📄 Learn more in the pre-print: https://lnkd.in/equGq5vn 🔎 You want to learn more about #Gri3D ? Check our website: https://lnkd.in/eR2bXQJt  #3Dcellculture #organoids #tcellkillingassay #workflows #assay #biotechnology #research #personalizedmedicine #immunooncology #screening

Researchers have found that a certain bacterium called Fusobacterium nucleatum, which is often found in the oral cavity, can promote the proliferation and migration of pancreatic cancer cells through signaling within the host's own cells. This groundbreaking finding sheds light on how the tumor and its surrounding environment interact and opens up new possibilities for prognosis and therapeutic intervention. The study explores the role of Fusobacterium nucleatum in promoting tumor progression in pancreatic ductal adenocarcinoma (PDAC) cells. The researchers found that infection with F. nucleatum induced the secretion of specific cytokines, including GM-CSF, CXCL1, IL-8, and MIP-3α, which in turn promoted proliferation, migration, and invasion in PDAC cells. These findings highlight the importance of host-microbe interactions in pancreatic cancer and could potentially guide therapeutic interventions. #Join #The #Discussion: How do you think this discovery about the influence of bacteria on cancer cells could potentially improve treatment outcomes? Share your insights in the comments below! #Comment, #Like, #Share & #Follow Dr. David Mwin for more scientific/ Clinical research insights. #Source: In the comments #PancreaticCancerResearch #MicrobiomeImpact #CancerTreatment #MedicalBreakthrough #ResearchMatters #CancerAwareness #ScientificDiscovery

A "cold tumor" is a tumor that is not likely to trigger a strong immune response. Cold tumors tend to be surrounded by cells that are able to suppress the immune response and keep T cells (a type of immune cell) from attacking the tumor cells and killing them. Cold tumors usually do not respond to immunotherapy. In this Review publication, M. Teresa Villanueva describes how "RNA delivery heats up cold tumours". Scientists have designed lipid particle aggregates (LPAs) containing mRNA antigens that activate a RIG-I-mediated immune response that activates immunity in the periphery and within the tumour microenvironment (TME), resulting in the rejection of tumours in several animal models and in a first-in-human trial in patients with glioblastoma. https://lnkd.in/eKNcM4nh Springer Nature Group #LNP #RNA #mRNA #celltherapy #genetherapy #LPA #lipids #nanoparticles #DDS #precisionmedicine #biotechnology #cancer #research #glioblastoma

In the ever-evolving landscape of medical science, CAR T-cell therapy stands out as a beacon of hope. This innovative treatment represents a significant leap forward in our fight against cancer, especially blood cancers like leukemia and lymphoma. 🧬 What makes CAR T-cell therapy so revolutionary? It's all about harnessing the body's own defense mechanism. The process involves extracting a patient's T cells (a crucial part of the immune system), and then genetically engineering them to identify and attack cancer cells. Once modified, these cells are infused back into the patient, where they act as targeted cancer fighters. 🎯 The results? They've been nothing short of miraculous in some cases, with dramatic recoveries where traditional treatments had little impact. This personalized approach to cancer treatment opens up new avenues of hope for patients who have exhausted other options. However, it's not without its challenges. The complexity and cost of CAR T-cell therapy make it less accessible, but ongoing research is focused on making it more widely available. 🤝 As we continue to make strides in medical research, treatments like CAR T-cell therapy underscore the importance of investment and innovation in healthcare. It's a testament to the incredible potential of combining biology and technology to save lives. Join us in celebrating this groundbreaking advancement in medical science! 💡👩🔬 #CARTCellTherapy #CancerResearch #MedicalInnovation #Healthcare #Biotechnology #oncology

#Call for #papers. Topics of interest include, but are not limited to, the following: -Epithelial–mesenchymal transition (EMT) and its pivotal role in initiating invasion and dissemination. -Matrix metalloproteinases (MMPs) and their impact on extracellular matrix degradation during metastatic progression. -Angiogenesis and lymphangiogenesis as facilitators of tumor vascularization and metastatic niche establishment. -Cancer stem cells and their contribution to therapy resistance, tumor relapse, and metastatic potential. -Immune system modulation of metastasis, encompassing both immune surveillance and immune cell promotion of spread. -Impact of immunotherapy on metastasis response and toxicity.

💡 NEW FINDINGS: Tumor cell evolution plays a key role in disease progression and treatment response.    New research, led by Dr. Xin Wei Wang and team, uncovers how tumor cell lineage, B cell activity and the tumor microenvironment could influence the process. Read more in Nature Portfolio: https://lnkd.in/dEXqCc3B National Cancer Institute (NCI) Dr. Wang is the Deputy Chief of our Laboratory of Human Carcinogenesis and the Co-Director of our Liver Cancer Program. He oversees a basic/translational research program emphasizing new molecular approaches to define tumor subtypes and identify biomarkers for early detection, diagnosis, prognosis and prediction, to delineate the molecular mechanisms of liver cancer with applications towards precision medicine. #CancerResearch #LiverCancer #Innovation #Health #Medicine

Four imaging panels in one creates the ability to evaluate the multiparametric response in the tumor microenvironment in one scan, crucial to predicting therapeutic drug efficacy. ✔ The Tissue Architecture Panel identifies the underlying cellular and structural markers of the tumor. ✔ The Immune Phenotyping Panel delineates lymphoid and myeloid cell subtypes of immune cell infiltrates in tumors. ✔ The Cancer Cell Process Panel reveals signaling pathway activation, proliferation, metabolism, and epithelial to mesenchymal transition, thus highlighting the variety of cancerous cell processes. ✔ The Immune Activation Panel contains 3 distinct markers that enable identification of relevant activated immune cells in tumors. Take a closer look: https://lnkd.in/gG3rXnPE #preclinical #mousemodels #cancerresearch

📢 Thrilled to share the latest publication using Cell Avidity to uncover unique insights for cancer immunotherapies. 📚🔍Here researchers uncover the tremendous potential of targeting inhibitory immune checkpoint molecules on neutrophils, specifically SIGLEC 5/14. 🔬 The research demonstrates that by strategically blocking these molecules, we observed a remarkable surge in cellular avidity between neutrophils and tumor cells. What's even more promising is the observed correlation with neutrophil-mediated Antibody-Dependent Cellular Cytotoxicity (ADCC) 🎯. This discovery opens up new avenues for enhancing the immune response against tumors, offering fresh insights into the intricate dynamics of the immune system's frontline defenders. 📖 Check out the publication here: https://bit.ly/3TVekfM 📎 Check out the full list of cell avidity publications here: https://bit.ly/3TVe28G #CancerImmunotherapy #ResearchBreakthrough #ScientificDiscovery #ImmuneResponse #InnovationInScience #ScienceCommunity #MedicalResearch

Researchers find one of engines behind pancreatic cancer A team of scientists have found one of the engines that drive cancer of the pancreas, one of the most aggressive tumors, in a discovery that has enabled them to identify a therapeutic target to hopefully slow the advance of the disease. Favoring the growth of this form of tumor which is still sadly very lethal, the ductal adenocarcinoma of the pancreas, is a special alliance between a particular type of immune cells, called IL-1beta macrophages, and some very aggressive tumor cells, known for being linked to inflammation. It's a sort of self-feeding vicious circle. The macrophages make the tumor cells more aggressive, and the tumor cells re-program the macrophages capable of favoring inflammation, and the progression of the disease. #opportunities #strategy #programming #design #team #research #data #health #development #collaboration #projects #testing #immunotherapy #cancer #technology #biotechnology #healthcare #medicine #oncology #precisionmedicine #liquidbiopsy #rna #dna #venturecapital #startup #immunooncology #tcells #innovation #growth #tech #lifesciences #biopharma #oncodxrx