We are to share that we've been awarded a $5.6 million grant through the Coast-to-Coast Consortium to advance our pioneering work with the National Institutes of Health's (NIH) All of Us Research Program! "The All of Us Research Program provides an unprecedented opportunity to include diverse populations in large-scale genomic research,” Alexander Borowsky, a professor of pathology and laboratory medicine said. “By including individuals from historically underrepresented communities, we can uncover insights into genetic variations that may have been overlooked in the past, ultimately leading to more equitable health care for all." Learn more: https://lnkd.in/g4JAxKiA
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I am thrilled to have some of my postdoctoral work on Fusobacterium nucleatum published in Cell Host & Microbe! Check out my article to learn about the role of F. nucleatum subspecies in oral disease, and why distinguishing between these subspecies is important for the entire field of F. nucleatum research. https://lnkd.in/ghQEvyGg
Stratification of Fusobacterium nucleatum by local health status in the oral cavity defines its subspecies disease association
cell.com
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Strategic Partnerships Manager, Predictive Genomics @ Thermo Fisher | Chair, MedTech Europe Cancer Sector Group
The biggest challenge to healthcare systems in the long run remain the prevalence (and cost!) of non-communicable diseases, a.k.a. common complex diseases. It’s great to see Genomic Medicine Sweden recognising the problem! My colleague Anne Helness will share Thermo Fisher Scientific vision for Predictive Genomics, an innovative set of tools to help individuals and healthcare systems to assess the risk of developing diseases AND improve drugs effectiveness/decrease adverse drug reactions. #PersonalisedMedicine #genomics #NCDs
Welcome to the conference Precision health around the corner – deciphering complex diseases! 📅 Date: 26th of January ⏰ Time: 9 am - 7 pm 📍Location: Wenner-Gren Center, Stockholm It is our pleasure to announce the second conference for GMS Complex Diseases. The event aims at bringing together researchers and clinicians to accelerate the clinical implementation of precision medicine of complex diseases. The meeting is open to everyone with professional interest in the field. More info and sign up 👇 https://lnkd.in/dViQxesH Speakers: Celeste Porsbjerg, Professor, Bispebjerg and Frederiksberg Hospital, Department of Respiratory Medicine Christina Jern, Professor, Chief Physician, University of Gothenburg, Department of Laboratory Medicine Mia Wadelius, Professor, Uppsala University, Department of Medical Sciences Craig Wheelock, Associate Professor, Karolinska Institutet, Institute of Environmental Medicine Richard Rosenquist Brandell, Director Genomic Medicine Sweden, Professor of Clinical Genetics/ Senior Physician, Karolinska Institutet Åsa Johansson, Associate Professor, Uppsala University, Department of Immunology, Genetics and Pathology Ingrid Skeleton Kockum, Professor, Karolinska Institutet, Department of Clinical Neuroscience Johan Sundström, Professor, Uppsala University, Department of Medical Sciences Anne Helness, Sr. Technical Sales Specialist – Human Predictive Genomics, Nordics and Baltics Thermo Fischer Scientific Organizing committee: Bo Jacobsson, Åsa Johansson, Craig Wheelock and Harald Hedman-Rebernig
Complex Diseases Conference 2024
https://genomicmedicine.se
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📣 Exciting news! Our cutting-edge research topic, 'Biomarkers and Mechanisms of Gastrointestinal Diseases,' is now live on 'FRONTIERS IN GENETICS.' Together with distinguished colleagues, Dr. Omer Yilmaz from Massachusetts Institute of Technology and Dr. Zerrin Isik from Dokuz Eylul University, we're inviting thought leaders and innovative researchers to contribute their invaluable insights through a research article. This is your chance to join us at the frontier of knowledge and contribute to the understanding of these critical diseases. We believe that your work can make a difference, help drive scientific progress, and inspire future breakthroughs. We can't wait to collaborate with you and bring your valuable contributions to light! 🌟 Remember, every discovery starts with a single step. Let's embark on this scientific journey together. #Research #GastrointestinalDiseases #Biomarkers #Genetics
Biomarkers and Mechanisms of Gastrointestinal Diseases
frontiersin.org
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Bioinformatician & Health Biologist - PhD Student at FIB La Princesa
Excited to share our paper published in Nature Communications after four years of work‼ Rebeca Martínez, Pablo Sacristán-Gómez and me, Nuria Sánchez de la Blanca Carrero, as co-first authors in Fundación para la Investigación Biomédica del Hospital Universitario de La Princesa, used spatial transcriptomics to reveal new molecular signatures and pathological subpopulations of cells in autoimmune thyroid diseases. 🔎 This project was in collaboration with Holger Heyn's and Fatima Sanchez-Cabo's groups. 💻 #spatialtranscriptomics #scRNAseq #thyroid #autoimmunity 📌 https://lnkd.in/e73hD2eR
Unraveling the molecular architecture of autoimmune thyroid diseases at spatial resolution - Nature Communications
nature.com
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Explore SeraCare's groundbreaking role in addressing fetal fraction (FF) measurement variability for reliable non-invasive prenatal testing (NIPT). Our Seraseq Matched NIPT reference materials were instrumental in EMQN CIC and GenQA (Genomics Quality Assessment) proficiency testing across 477 labs and served as internal controls at Amsterdam UMC, shedding light on FF determination methods. Discover how our sustainable NIPT reference materials informed FF variability assessment and the pressing need for lab-specific ranges. Read more: https://hubs.ly/Q02vyk5g0
Variability in Fetal Fraction Estimation: Comparing Fetal Fractions Reported by Noninvasive Prenatal Testing Providers Globally
academic.oup.com
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Scientist, RAN BioLinks co-founder: Driven by a passion for science and innovative solutions to accelerate research
Hi friends in science! The tissue is the issue… Another great work showing the power of blood proteomics and machine learning to predict organ aging and its effects on health outcomes. We used such prediction models & proteomics in heart failure in the past and I truly believe that we can uncover a lot about the finctioning of our tissues without the need of invasive sampling or extensive omics analysis. Check this out!
Thrilled to share our co-founders' Tony Wyss-Coray, Jarod Rutledge, Ph.D., and Hamilton Oh groundbreaking publication in Nature! 📢 We now have evidence that accelerated organ aging can significantly elevate the risk of age-related diseases and mortality (up to 6x higher chance for some people!). In a groundbreaking study, the team demonstrates the power and potential of advanced proteomics by revealing that our blood contains information that allows us to understand how our individual organs are aging. Through the measurement of over 5,000 circulating blood proteins from around 6,000 individuals, the study explores organ-specific aging “clocks” to understand their interpretability and predictive power. It is well understood that we all age differently. This work proposes a new approach to monitoring aging at an organ level, offering us novel personalized insights for guiding longevity care and interventions. We're inspired by their work and proud to continue to build on these pioneering insights at Teal. We believe these findings have the potential to transform healthcare and impact millions of lives! Congratulations to the team for their incredible scientific achievement! #LongevityResearch #HealthyLiving #AgingScience #Proteomics #BiologicalAging #LifespanExtension #AgingBiomarkers #BiologicalCocks #NaturePublication #ScientificAchievement #BiomarkerDiscovery #ResearchMilestone #Stanford Markus Okumus, Alex Boches, Laurent Fischer, Benoit Lehallier, Jay Wohlgemuth MD, Ray Tabibiazar, Mike Aicher, Basilio Cieza Huaman, Paritosh Kulkarni, Bharat Tewarie
Organ aging signatures in the plasma proteome track health and disease - Nature
nature.com
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A new paper from Saarland University researchers on the use of 3D lung #organoids to replace preclinical #animaltesting for the study of #senescence, which can lead to better understanding of chronic lung disease conditions like #COPD and #CF. "...in-depth analyzes using human organoids are often more insightful than animal studies in terms of cellular mechanisms and the effect on humans, particularly when interspecies differences are considered..." Find the paper in #RespiratoryResearch by BMC: https://lnkd.in/d6vyPHZW Congratulations to the authors: Michelle Brand, Felix Ritzmann, Dr. Kathrin Kattler, Deivydas Milasius, Yiwen Yao, Christian Herr, Susanne Kirsch-Dahmen, Rolf Mueller, Daniela Yildiz, Robert Bals, and Christoph Beisswenger.
Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence - Respiratory Research
respiratory-research.biomedcentral.com
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Hot off the press! Amazing Nature paper on accelerated organ aging and risk of age-related diseases. This was only possible with a technology that can assay large number of proteins on large study population with unmatched sensitivity and consistency. Imagine what our latest SomaLogic Somascan 11k assay will uncover. Proteomics at genomics scale! #agingresearch #plasma #proteomics #highthroughput
Thrilled to share our co-founders' Tony Wyss-Coray, Jarod Rutledge, Ph.D., and Hamilton Oh groundbreaking publication in Nature! 📢 We now have evidence that accelerated organ aging can significantly elevate the risk of age-related diseases and mortality (up to 6x higher chance for some people!). In a groundbreaking study, the team demonstrates the power and potential of advanced proteomics by revealing that our blood contains information that allows us to understand how our individual organs are aging. Through the measurement of over 5,000 circulating blood proteins from around 6,000 individuals, the study explores organ-specific aging “clocks” to understand their interpretability and predictive power. It is well understood that we all age differently. This work proposes a new approach to monitoring aging at an organ level, offering us novel personalized insights for guiding longevity care and interventions. We're inspired by their work and proud to continue to build on these pioneering insights at Teal. We believe these findings have the potential to transform healthcare and impact millions of lives! Congratulations to the team for their incredible scientific achievement! #LongevityResearch #HealthyLiving #AgingScience #Proteomics #BiologicalAging #LifespanExtension #AgingBiomarkers #BiologicalCocks #NaturePublication #ScientificAchievement #BiomarkerDiscovery #ResearchMilestone #Stanford Markus Okumus, Alex Boches, Laurent Fischer, Benoit Lehallier, Jay Wohlgemuth MD, Ray Tabibiazar, Mike Aicher, Basilio Cieza Huaman, Paritosh Kulkarni, Bharat Tewarie
Organ aging signatures in the plasma proteome track health and disease - Nature
nature.com
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Human plaque myofibroblasts are an excellent model to study the mechanisms of atherosclerosis! Check out our new paper in JAHA! Michele Buono, Ernest Diez Benavente, Lotte Slenders, Daisey Methorst, Daniëlle Tessels, Eloi Mili, Roxy Finger, Daniek Kapteyn, Mark Daniels, Noortje Van den Dungen, Jorg Calis, Barend Mol, Gert Jan de Borst, Dominique De Kleijn, Gerard Pasterkamp, Hester den Ruijter Plaque myofibroblasts play a significant role in the onset and progression of atherosclerotic disease, and yet, vascular smooth muscle cells are still dominantly used in research despite clear phenotypic differences. In our latest paper, we introduce a novel method to isolate and culture myofibroblast cells directly from plaques, ensuring they retain their natural properties and making them a more accurate in vitro model for atherosclerosis studies. Circulatory Health UMC Utrecht UMC Utrecht
Human Plaque Myofibroblasts to Study Mechanisms of Atherosclerosis
ahajournals.org
Senior Scientific Officer, Cancer Biomarkers Research at National Cancer Institute (NCI)
1wCongrats Sandy on your phenomenal achievements.